The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

Researchers reviewed studies about mTOR, a cell system that senses food and controls growth and repair. In laboratory animals and other organisms, lowering mTOR activity sometimes extended lifespan and improved some signs of ageing. The review also considered rapamycin, a medicine that lowers mTOR activity, but most evidence came from animals rather than people. Human studies were too limited to show whether this approach safely helps people live longer.

What this means for you: This does not justify buying rapamycin or supplements marketed as mTOR blockers. The findings are promising in animals, but possible side effects and uncertain human benefits mean it is not a proven longevity treatment.