Study

Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction

Amin P, Sarabi A, Choe S, Scott S, Suh S, Mesinkovska NA

PRIMARY 2025
Summary Does taking hyaluronic acid by mouth improve skin and wrinkles? Show / hide ↓

The study examined oral hyaluronic acid, a substance that helps hold water in body tissues. It focused on skin hydration, meaning how much water the skin contains, skin elasticity, meaning how well it springs back, and wrinkle depth. The available record does not report how many people participated, how long they took the supplement, or what the results were. It therefore does not show whether the supplement worked better than a placebo, an inactive treatment.

What this means for you: This record is not enough to justify buying an oral hyaluronic acid supplement for skin benefits. Wait for complete results from a well-designed human trial before treating it as effective.

weak evidence
DesignPRIMARY
TierTier 2, Product RCT (not peer-reviewed)
Year2025
JournalJ Drugs Dermatol
Added to NO1GEVITYJun 17, 2026

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