Study
First Large-Scale NMN RCT Shows Significant Improvement in Cognitive Function
Largest NMN RCT to date reports significant cognitive improvement in healthy adults.
Summary Does NMN improve thinking and memory in healthy adults? Show / hide ↓
Researchers reportedly gave NMN, a supplement that may raise levels of a molecule used by cells for energy, or a look-alike placebo to healthy adults. People were assigned to the groups by chance, and neither participants nor researchers knew who received which one. The trial reportedly found better cognitive function, meaning thinking and memory skills, with NMN. The number of participants, dose, treatment length, exact results, and peer-reviewed publication were not provided.
What this means for you: This is not enough information to decide whether NMN improves cognition or is worth buying. Wait for the full published study, including the size of the benefit and possible harms.
weak evidenceThe largest randomized, double-blind, placebo-controlled trial of nicotinamide mononucleotide (NMN) to date reported significant improvement in cognitive function. Prior NMN trials were small (n=20-80) and focused on physical endpoints like grip strength and walking speed. This trial extends the evidence base for NMN beyond physical performance to cognitive outcomes. The dose and duration were not fully specified in the source material at time of writing. This is a meaningful step forward because most NAD+ precursor research has been in preclinical models or small human studies, and cognitive aging is the outcome most consumers care about. The finding should be read with caution until peer-reviewed publication confirms the effect size, comparator, and statistical significance threshold.
Significant improvement in cognitive function observed in the largest NMN RCT conducted to date.
Results reported via secondary source (longevitynews.io) before peer-reviewed publication. Effect size and p-values not available at time of writing.
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