Study
Acid hydrolysis of jaboticaba (Myrciaria jaboticaba) peel and seed powder increases urolithin excretion in a cross-over clinical trial with normoweight subjects.
In 23 normal-weight adults, hydrolysed jaboticaba powder increased urinary urolithin excretion by up to 69% over 48 hours.
Summary Does treated jaboticaba powder help the body produce more urolithins? Show / hide ↓
Researchers gave 23 normal-weight adults a single dose of jaboticaba peel and seed powder. Each person took the untreated powder on one occasion and acid-treated powder on another, with a 14-day gap. The researchers measured urolithins, compounds made by gut bacteria from plant chemicals, in urine collected for up to 72 hours. The treated powder led to 69% more urolithin excretion during the first 48 hours and 50% more over 72 hours. This measured a chemical change in urine, not an improvement in health or longevity.
What this means for you: This may show that acid-treated jaboticaba changes how the body processes its plant compounds. It does not show a benefit for energy, exercise, disease prevention, or lifespan, so it is not a reason to buy this product.
early evidenceThis randomised crossover clinical trial studied 23 normal-weight adults after a single 3 g capsule dose of jaboticaba peel and seed powder. Participants received either non-hydrolysed powder or acid-hydrolysed powder, separated by a 14-day washout. Urine was collected for up to 72 hours to assess urolithin metabolites.
The hydrolysed preparation contained 57.1 mg free ellagic acid, compared with 17.8 mg in the non-hydrolysed preparation, a 3.2-fold difference. Glucuronidated urolithins made up 85% of total urinary excretion. Urolithin A 3/8-glucuronide was the main metabolite, accounting for 54% of total excretion after non-hydrolysed powder and 57% after hydrolysed powder. Urolithins were detected in urine 8 hours after hydrolysed powder. Time to peak excretion did not differ materially, at 29.2 hours for non-hydrolysed powder and 28.3 hours for hydrolysed powder.
Acid hydrolysis increased total urolithin excretion by up to 69% from 0 to 48 hours and by 50% over 72 hours. This is evidence of altered absorption and microbial metabolism, not of a health benefit. It did not test a urolithin A supplement, physical function, mitochondrial function, disease outcomes or longevity.
Acid hydrolysis of jaboticaba peel and seeds increased urolithin production in normal-weight subjects, probably by increasing availability for microbial conversion.
This was a 23-person, single-dose crossover study with urinary metabolites as the outcome. It tested processed jaboticaba powder rather than urolithin A itself and provides no clinical-effect evidence.
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