Homocysteine-lowering trials and cardiovascular disease outcomes: a meta-analysis

Researchers combined results from many randomized trials of vitamins that lower homocysteine, an amino acid in the blood linked to heart disease. The trials included adults who often already had heart disease, kidney disease, or other cardiovascular risks. Participants took folic acid, vitamin B6, vitamin B12, or combinations, and were compared with people taking a placebo or usual care. Lowering homocysteine did not clearly reduce heart attacks, overall heart disease, or deaths. Some results suggested fewer strokes, but this benefit was small and inconsistent.

What this means for you: Do not buy B-vitamin supplements solely to prevent heart attacks or strokes based on this study. These vitamins can still be useful for a diagnosed deficiency or certain life stages, such as pregnancy, when advised by a clinician.