Study
The effect of Urolithin A (Mitopure®) supplementation on muscle strength in healthy middle-aged adults
ISRCTN registration of the same ATLAS 2 urolithin A muscle-strength trial listed on ClinicalTrials.gov, sponsored by Amazentis and run in Cork, Ireland.
Summary Can urolithin A improve muscle strength in healthy adults aged 40 to 65? Show / hide ↓
Researchers plan to give healthy adults aged 40 to 65 either urolithin A, a supplement marketed as Mitopure, or a placebo, a product with no active ingredient. About six months of treatment will be compared across three groups receiving 500 milligrams, 1,000 milligrams, or the placebo. The trial is randomised, meaning people are assigned by chance, and double-blind, meaning neither participants nor researchers know who receives the supplement during the study. The study is planned in Cork, Ireland, but no results are available yet.
What this means for you: This registration does not show that urolithin A improves strength. There is not enough evidence to buy it for this purpose based on this study alone.
early evidenceThis is the ISRCTN registry entry for the ATLAS 2 trial, mirroring the ClinicalTrials.gov listing (NCT07231783). Sponsor is Amazentis SA, Switzerland; funder is Amazentis. Submission date 21 October 2025, registration 28 October 2025. Design: randomised, double-blind, placebo-controlled, parallel, single-centre, testing Mitopure at 500 mg and 1000 mg against placebo for six months in healthy adults aged 40-65. Study runs at Atlantia Clinical Trials, Cork, Ireland, principal investigator Nontokozo Yusuff. Enrolment window December 2025 to April 2027, last-participant-last-visit expected October 2027. The plain-English summary states participation offers no direct benefit and poses negligible risk, with standard blood draw, DEXA scan, and fitness-testing procedures. No results are available. This entry exists to give the trial a second, independently searchable registration record, useful for verifying the study is genuinely running rather than abandoned after registration, a known failure mode in supplement research.
n/a - trial ongoing, no results reported
Duplicate registration of the same trial as NCT07231783. No independent data. Recruitment status listed as ongoing as of the source date.
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1 encyclopedia entries reference this study.