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Layer 1 · Decision
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DoNotAge

SIRT6Activator®

Sirtuin activator · Capsule · 366 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving
SIRT6 Activator 400 mg
Form
Capsule
List price (catalog, USD)
$97.00
Price per serving
$0.27List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
Servings per container
366
Catalog monthly estimate
$7.95
Testing disclosure
Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
SIRT6 Activator400 mg

What to check on the label

  • Whether the label says trans-resveratrol with a purity percentage, or only 'resveratrol' or 'Japanese knotweed extract'.
  • Whether the milligrams refer to the compound or to the extract it comes from.
  • Powders list a scoop size. Check that it matches the serving in the catalog.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

3.8/10
Overall score
#17 / 17 in Sirtuin activator

Tested by independent lab.

Read the full evidence vault
Add to compareVisit brand site →
Watch out
Tier 5
Mechanistic / animal / marketing
Only mechanistic studies or marketing claims. No human RCT for this ingredient.
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 0.9 of 10. Primary ingredient is SIRT6 Activator (evidence grade E). It delivers only 400 mg, 40% of the studied range low edge (1000 mg). Under-dosed. Read the rule → 0.9
Transparency (20%) Why 7.0 of 10. Earned points for independent third-party testing and all doses disclosed. Lost points for no public certificate of analysis. Read the rule → 7.0
Value (10%) Why 6.4 of 10. One day at the trial dose costs about $2.65. That is more expensive than average (219 of 313 by cost per effective day). Read the rule → 6.4
Formulation (10%) Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule → 5.0 Default. No absorption data on file.
Safety (5%) Why 7.0 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 7.0
Community sentiment (5%) Why 8.0 of 10. No external reviews found, so community sentiment defaults to neutral. Community never counts as clinical evidence. Read the rule → 8.0
Composite How this 3.8 is built. 0.50 × 0.9 + 0.20 × 7.0 + 0.10 × 6.4 + 0.10 × 5.0 + 0.05 × 7.0 + 0.05 × 8.0 = 3.8 out of 10. Safety caps applied after. 3.8
3.8 composite
Dose vs. studies50%0.9
Transparency20%7.0
Value10%6.4
Formulation10%5.0
Safety5%7.0
Community5%8.0

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

3.8 / 10
Best for
Budget-friendly
Avoid if
Only 40% of trial dose, No public lab certificate
Full-dose status
40% of trial dose
Price/month
$8
COA status
Not public
Biggest caveat
Dose-evidence score of 0.9 is below average for the site.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $97.00
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context
In plain language

Why this scored this way

This DoNotAge SIRT6Activator® scores 3.8, making it among the lowest-scoring products we track. It delivers 400mg of SIRT6 Activator, 40% of the studied range low edge (1000mg) with grade E evidence. At $2.65/day it's among the more expensive options in Sirtuin activator.

What drives the score up

  • Tested by independent lab (transparency 7.0).
  • Community score of 8.0 with positive consumer feedback.

What drags it down

  • Dose-evidence score of 0.9 is below average for the site.
  • Overall dose is only 40% of the trial dose across ingredients.
  • SIRT6 Activator (400.0mg is 10% of the 4000mg trial dose) is significantly under-dosed.
  • No public lab certificate available for independent verification.
  • At $2.65/day it's on the expensive side.

Why you'd choose it

  • You want a tested by independent lab product.

Why you might skip it

  • You want a product with a publicly available CoA.
  • You need a full trial dose of sirt6 activator (this product under-doses it).
  • You want a cheaper option (this is $2.65/day).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

SIRT6 Activator

DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.

1 landmark RCT · US: Dietary supplement · EU: Food supplement (seaweed-derived)
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
40% of trial dose
Well below the trial dose
Cost at trial dose
$2.65/day at trial dose
What one effective daily dose actually costs
Transparency
7.0/10 · No public lab certificate
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
Underdosed
Dose at 40% of trial dose
Below 50% of the dose used in published clinical trials.
Plain English

What’s inside

The main ingredients of this product, in plain language.

SIRT6 Activator400 mgEvidence E

DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.

Read about SIRT6 Activator →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$97
per bottle · 366 servings
Dose vs. research
Below trial dose 40%
of published effective dose
$ / day at studied dose
$2.65
what one effective daily dose costs
$ / g active
$0.66
per gram of active substance
Independently checked

Data verification

COA status
Not public
Evidence grade
E
Per-ingredient breakdown
ESIRT6 Activator

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
SIRT6 Activator
DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.
Rahman et al. 2014
400 mg 10% of trial dose
4000 mg
4.1 /5
Low confidence
150 reviews across 1 platforms (1 sources)
Source diversity: 23%
Trustpilot
PraiseIncreased energy after combining with NMN over 12 monthsFeeling noticeably better overall
Last checked: 2026-08-20

Consumer signals

Consumer signals gathered from 1 platform.

Compiled from a DoNotAge product page listing located during research; verified at build time.

Medium confidence
Trustpilot

150 reviews · 4.1/5 · positive sentiment

PraiseIncreased energy after combining with NMN over 12 monthsFeeling noticeably better overall150+ verified 5-star Trustpilot reviews cited
Themes

DoNotAge's SIRT6 Activator page cites over 150 verified 5-star Trustpilot reviews, with customer testimonials emphasizing sustained energy gains after months of combined use with NMN.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

SIRT6 ActivatorRahman et al. 2014
Important to know
SIRT6 ActivatorFucoidan is inexpensive as a seaweed extract. High-priced 'SIRT6 activator' branding doesn't mean higher potency, check fucoidan mg/capsule.

Editorial notes

Branded fucoidan extract sold at a large premium versus generic fucoidan supplements; SIRT6-activation claims rest on in-house/preclinical data rather than published human trials.

Go deeper

Where this sits

Actives inside
SIRT6 Activator
Category
See all in Sirtuin activator →
Brand
DoNotAge profile →
Add to compare Visit brand site →
Brand owners

Spot an error?

If you are the manufacturer or brand owner of SIRT6Activator® and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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