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Nootropics Depot

Berberine HCl 500 mg

Metabolic · Capsule · 60 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving
Berberine 500 mg
Form
Capsule
List price (catalog, USD)
$25.00
Price per serving
$0.42List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
Servings per container
60
Serving size (label)
0.5 g
Catalog monthly estimate
$12.50
Testing disclosure
Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Berberine500 mg

What to check on the label

  • Whether the figure is per capsule or per day, and how many capsules the label's daily serving contains.
  • The salt form named (berberine HCl, dihydroberberine, Ca-AKG). The catalog does not convert between forms.
  • Many labels carry interaction warnings for berberine. Read the label warning and the safety section on this page.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

6.8/10
Overall score
#3 / 20 in Metabolic

Public lab certificate, tested by independent lab.

Read the evidence (1 study)
Add to compareVisit brand site →
Tier 3
Ingredient RCT (matching dose)
The ingredient was tested in an RCT at the same dose this product sells.
See the 1 supporting study
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 7.2 of 10. Primary ingredient is Berberine (evidence grade A). It delivers only 500 mg, 56% of the studied range low edge (900 mg). Under-dosed. Read the rule → 7.2
Transparency (20%) Why 9.0 of 10. Earned points for public certificate of analysis and independent third-party testing and all doses disclosed. Read the rule → 9.0
Value (10%) Why 8.4 of 10. One day at the trial dose costs about $1.25. That is cheaper than average (139 of 313 by cost per effective day). Read the rule → 8.4
Formulation (10%) Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule → 5.0 Default. No absorption data on file.
Safety (5%) Why 8.5 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 8.5
Community sentiment (5%) Why 9.2 of 10. Sentiment across 8 external review source(s) is mostly positive. Community is a signal about daily use, not proof of effect. Read the rule → 9.2
Composite How this 6.8 is built. 0.50 × 7.2 + 0.20 × 9.0 + 0.10 × 8.4 + 0.10 × 5.0 + 0.05 × 8.5 + 0.05 × 9.2 = 6.8 out of 10. Safety caps applied after. 6.8
6.8 composite
Dose vs. studies50%7.2
Transparency20%9.0
Value10%8.4
Formulation10%5.0
Safety5%8.5
Community5%9.2

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

6.8 / 10
Best for
Public lab certificate, Budget-friendly
Avoid if
Only 56% of trial dose
Full-dose status
56% of trial dose
Price/month
$12
COA status
Public
Biggest caveat
Berberine (500mg is 33% of the 1500mg trial dose) is significantly under-dosed.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $25.00
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context

Our summary

Nootropics Depot's berberine offering is best understood in two parts: a discontinued plain 380mg standalone capsule (2018 to 2021) and its current successor, a 500mg berberine HCl + 100mg silymarin combination capsule dosed at 1 capsule three times daily (1500mg/day berberine total). That 1500mg/day dose lands exactly on the classic Yin 2008 trial dose that established berberine's metformin-comparable glycemic effect (https://pubmed.ncbi.nlm.nih.gov/18442638/), which supports a Tier 3 (ingredient RCT at matching dose) rating for the berberine component, though no trial has tested NTD's specific silymarin-added formulation, so the added ingredient's incremental benefit is a plausible-but-unproven bioavailability claim rather than a demonstrated one. NTD's per-lot, publicly linked COA PDFs are a real and verifiable transparency differentiator versus most supplement competitors, even accounting for the fact that the primary lab is in-house (albeit ISO/IEC 17025-accredited). Buyers should treat 2023's 'Nature's Ozempic' TikTok framing as clearly unsupported, berberine's effect size is in metformin's range, not semaglutide's, and should be aware of dose-dependent GI side effects and clinically meaningful CYP3A4/CYP2D6/CYP2C9 drug interactions (warfarin, cyclosporine, tacrolimus, some statins) before combining with prescription medications.
In plain language

Why this scored this way

This Nootropics Depot Berberine HCl 500 mg scores 7.6, making it a strong scorer. It delivers 500mg of Berberine, 55% of the studied range low edge (900mg) with grade A evidence (strong human trial data). Transparency is a clear strength (score: 9.0), with third-party testing and a public lab certificate.

What drives the score up

  • Dose-evidence score of 7.2 shows decent alignment with trial doses.
  • Quality transparency of 9.0: tested by independent lab with a public lab certificate.
  • Community score of 9.2 with positive consumer feedback.
  • Berberine has grade A evidence and is dosed at 55% of the trial dose.

What drags it down

  • Berberine (500mg is 33% of the 1500mg trial dose) is significantly under-dosed.

Why you'd choose it

  • You want a reasonably priced metabolic product.
  • You want Berberine from a Nootropics Depot product.
  • You prioritise tested by independent lab products with public lab certificates.

Why you might skip it

  • You need a full trial dose of berberine (this product under-doses it).
  • You want better value (this is $1.25/day with a value score of 8.4).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Berberine

Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.

1 landmark RCT · US: Dietary supplement · EU: Restricted in Italy (drug status ≥10 mg); food supplement elsewhere
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
56% of trial dose
Below the full trial dose
Cost at trial dose
$1.25/day at trial dose
What one effective daily dose actually costs
Transparency
9.0/10 · Public lab certificate (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

!
Review advised
berberine: CYP3A4 interactions
Safety signals
Drug interaction risk — berberine
Berberine inhibits CYP3A4, CYP2D6, and CYP2C9 even at moderate doses. Documented interactions with immunosuppressants, statins, anticoagulants, and antidiabetic drugs. Consult a physician if taking prescription medications.
Read more
Safety flag
berberine: CYP3A4 interactions
Dose or interaction risk detected. See ingredient page for details.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Berberine500 mgEvidence A

Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.

Read about Berberine →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$25
per bottle · 60 servings
Dose vs. research
Below trial dose 56%
of published effective dose
$ / day at studied dose
$1.25
what one effective daily dose costs
$ / g active
$0.83
per gram of active substance
Independently checked

Data verification

COA status
Public
Evidence grade
A
Per-ingredient breakdown
ABerberine

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Berberine
Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.
Yin et al. 2008 (Metabolism)
500 mg 33% of trial dose
1500 mg
4.6 /5
Medium confidence Strong value signal
2,430 reviews across 2 platforms (2 sources)
Source diversity: 46%
Examine.comTrustpilot
PraiseBerberine ranked among top-evidenced natural glucose modulators. NTD noted for H4.6/5. Users cite transparency and price.
Last checked: 2026-08-20

Consumer signals

Consumer signals gathered from 2 platforms.

Medium confidence

Consumer sentiment compiled from 2 public sources (Examine.com, Trustpilot).

Examine.com

positive sentiment

Praise

Berberine ranked among top-evidenced natural glucose modulators. NTD noted for HPLC purity.

Compiled from an Examine.com listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

2,430 reviews · 4.6/5 · positive sentiment

Praise4.6/5. Users cite transparency and price.

Compiled from a Trustpilot listing located during manual research; not independently re-verified against the live page at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Trustpilot (aggregate brand reviews for Nootropics Depot, not product-specific)
No affiliate relationship Not a paid placement

Customers broadly report satisfaction with Nootropics Depot's shipping speed, customer service, and perceived product quality/purity across its catalog.

Finding: Approximately 4.7/5 stars across roughly 2,000 reviews for the Nootropics Depot brand overall (not filtered to this specific berberine product).
How we use it: Used as brand-level reputation context only (N>500 threshold met per brief's Tier B bar), not as product-specific evidence for the berberine SKU; no berberine-specific quantitative breakout was available from the aggregate score.
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

r/NootropicsDepot subreddit, brand lab-testing transparency discussion thread
Has affiliate relationship Not a paid placement

Commenters (including apparent NTD-affiliated participants) explain and partially defend the in-house Omnient Labs testing model as ISO-accredited and rigorous, while acknowledging it is not fully third-party for every test.

Finding: No aggregate rating; qualitative community discussion of NTD's in-house-vs-outside lab testing practices.
How we use it: Downgraded to Tier C rather than B because this subreddit is brand-run/brand-participated rather than an independent community meta-thread with linked outside evidence, per the brief's affiliate-disclosure test; used only to corroborate the 'in-house but accredited' nuance already documented from the vendor's own transparency page, not as independent validation.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Examine.com
positive

Berberine ranked among top-evidenced natural glucose modulators. NTD noted for HPLC purity.

Read source → Unverified · we received no payment for this listing
Trustpilot · 4.6
positive

4.6/5. Users cite transparency and price.

Read source → Unverified · we received no payment for this listing
Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 3Ingredient RCT (matching dose)
5 studies mapped
Tier 3Ingredient RCT (matching dose)
Efficacy of berberine in patients with type 2 diabetes mellitus
Yin J, Xing H, Ye J · 2008 · Metabolism · n=116 · 500 mg three times daily (1500 mg/day) · 3 months
ingredient-levelpeer-reviewed
Berberine lowered HbA1c, fasting and postprandial glucose, and triglycerides to a degree statistically indistinguishable from metformin 500mg TID, and outperformed placebo; considered the foundational trial establishing 500mg TID as the standard clinical berberine dose.
Exact dose match to NTD's current label instruction (1 capsule x3/day = 500mg TID). This is an ingredient-level RCT on plain berberine HCl, not on NTD's specific berberine+silymarin combination product, so it supports the berberine component only, the added silymarin's incremental effect at this ratio has not been separately tested in this or any other trial we located.
Conflicts: None identified in the abstract; independent academic study (Shanghai Jiao Tong University-affiliated authors).
Source →
Tier 4Ingredient RCT (different dose)
Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension
Lan J, Zhao Y, Dong F, et al. · 2015 · Journal of Ethnopharmacology · n=2569 · Predominantly 0.9 to 1.5 g/day berberine across pooled trials · Variable, typically 6 to 24 weeks across pooled trials
ingredient-levelpeer-reviewed
Berberine combined with lifestyle intervention or oral antidiabetics produced greater reductions in glucose, HbA1c, and lipid parameters than lifestyle intervention alone, with a generally favorable safety profile aside from GI complaints.
Meta-analysis pooling dose ranges that bracket NTD's 1500mg/day label dose; supports the ingredient-level effect at approximately matching doses but is not product-specific and predates the silymarin combination formula.
Conflicts: None identified.
Source →
Tier 4Ingredient RCT (different dose)
Efficacy and safety of berberine alone or combined with statins for the treatment of hyperlipidemia: a systematic review and meta-analysis of randomized controlled trials
Ju J, Li J, Lin Q, Xu H · 2018 · American Journal of Translational Research (indexed via PubMed) · Berberine 0.3 to 1.5 g/day across pooled trials, alone or combined with statins · Variable across pooled trials, typically 8 to 24 weeks
ingredient-levelpeer-reviewed
Berberine alone and berberine+statin combinations improved LDL-C, total cholesterol, and triglycerides versus control; berberine groups showed a higher incidence of constipation/GI complaints than control.
Corroborates the dose-limiting GI side-effect profile the brief specifically flagged; dose range brackets NTD's 1500mg/day.
Conflicts: None identified.
Source →
Tier 4Ingredient RCT (different dose)
Effects of berberine on blood glucose, lipids, and inflammatory markers: a 2025 systematic review and meta-analysis of RCTs
Multiple authors (pooled meta-analysis, 12 RCTs / 889 patients) · 2025 · PMC-indexed (open access) · n=889 · Predominantly 0.9 to 1.5 g/day berberine across pooled trials · Variable across pooled trials
ingredient-levelpeer-reviewed
Confirms consistent, moderate improvements in glycemic and lipid markers across the accumulated berberine RCT literature at doses bracketing 1500mg/day, with GI tolerability as the main limiting factor.
Most recent (2025) synthesis of the ingredient-level literature; dose range matches NTD's label dose. Still not product-specific to the silymarin-combination SKU.
Conflicts: None identified.
Source →
Tier 4Ingredient RCT (different dose)
Repeated administration of berberine inhibits cytochromes P450 (CYP2D6, CYP2C9, CYP3A4) in humans
Guo Y, Chen Y, Tan ZR, Klaassen CD, Zhou HH · 2012 · European Journal of Clinical Pharmacology (PMC record) · 300 mg three times daily · Short-term repeated-dose pharmacokinetic study
ingredient-levelpeer-reviewed
Repeated berberine dosing significantly decreased CYP2D6, CYP2C9, and CYP3A4 enzyme activity, confirming clinically relevant drug-interaction potential (e.g., elevated cyclosporine levels reported in renal-transplant patients).
Directly supports the drug-interaction warnings included in claim_check/unverified for this product; dose tested (300mg TID) is lower than NTD's label dose (500mg TID), so interaction magnitude at NTD's dose may be equal or greater.
Conflicts: None identified.
Source →
Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

BerberineYin et al. 2008 (Metabolism)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Not supported
“"Nature's Ozempic", viral 2023 TikTok framing of berberine as a natural GLP-1-agonist-equivalent weight-loss alternative to Ozempic/semaglutide”
Berberine's mechanism (AMPK activation, insulin-sensitization) is pharmacologically distinct from GLP-1 receptor agonism, and the magnitude of effect is not comparable: berberine trials in the evidence base above show meaningful but modest glycemic/lipid improvements roughly on par with metformin (per Yin 2008, https://pubmed.ncbi.nlm.nih.gov/18442638/), while GLP-1 agonists like semaglutide produce substantially larger body-weight reductions (~15% of body weight in trials) versus berberine's much smaller observed effects. CNN's 2023 debunking piece and the Guardian's coverage of the TikTok trend both independently reached this same conclusion (https://www.cnn.com/2023/07/04/health/berberine-nature-ozempic-wellness, https://www.theguardian.com/us-news/2023/jun/11/berberine-weight-loss-supplement-tiktok-ozempic). Government/institutional sources (NCCIH, Mayo Clinic Press) concur that berberine is not a GLP-1-agonist substitute (https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know, https://mcpress.mayoclinic.org/nutrition-fitness/berberine-is-a-promising-supplement-but-its-not-a-magical-weight-loss-solution/).
Not a claim made on NTD's own product page, this is an external social-media narrative the research brief asked to be fact-checked given its relevance to consumer expectations for this product category.
Supported
“"Supports Healthy Glucose Metabolism"”
This is a modest, appropriately hedged structure/function claim consistent with the ingredient-level RCT evidence at matching or near-matching doses (Yin 2008, Lan 2015, and the 2025 meta-analysis in evidence_registry above), all of which show statistically significant glucose/HbA1c improvements at 0.9 to 1.5g/day berberine.
Vendor source
Supported
“"AMPK Activation" as the mechanism supporting metabolic benefits”
AMPK activation is a well-established, widely cited mechanism of action for berberine in the pharmacology literature and is consistent with the mechanistic basis underlying the clinical trials in evidence_registry; this is a mechanistic claim, not an outcome claim, and is accurately described.
Vendor source
Partial support
“"3rd Party Lab Tested & Verified" / general lab-testing transparency claims”
Verified live: lot-specific signed COA PDFs are directly linked from the product page and resolve successfully (confirmed 200 OK on BSTSCS1040925A_60ct_Signed.pdf, 2026-08-05). This is a genuine and unusually strong transparency practice versus category norms. Marked 'partial' rather than 'supported' only because the primary testing lab (Omnient Labs) is NTD's own in-house, ISO/IEC 17025-accredited lab rather than a fully independent third-party outside lab for every test category, NTD does supplement with outside labs (e.g., Alkemist) for select botanical work, but 'third-party' as used in the marketing claim conflates in-house-but-accredited testing with fully outsourced independent testing.
Vendor source
Unverifiable
“"Our Berberine + Silymarin formula is superior to standalone berberine due to significantly enhanced bioavailability" / "allowing us to achieve the same metabolic benefits with lower doses"”
Silymarin's general bioenhancing mechanism (P-glycoprotein and phase-II enzyme inhibition) is a real, published pharmacological phenomenon, but no clinical trial on this specific berberine+silymarin ratio/dose combination (500mg:100mg) demonstrating equivalent-or-better outcomes at a 'lower dose' than the 1500mg/day standard was located in this research pass. The claim may be directionally plausible but is not supported by a dedicated head-to-head trial, and NTD's own product still instructs the same 1500mg/day total berberine dose as the plain-berberine trials (Yin 2008), which undercuts the specific 'lower doses' framing.
Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • No dedicated, methodology-disclosed Innerbody or Healthline review of this specific berberine (or berberine+silymarin) SKU was located; Innerbody coverage of Nootropics Depot found in this research pass was brand-level (e.g., best-nootropics, best-tongkat-ali, best-lions-mane roundups) rather than berberine-specific, so no Tier A finding is included in external_reviews_registry for this exact product.
  • The 180ct variant's exact retail price could not be extracted (client-side JS renders it on variant switch); only the 60ct price of $34.99 was directly confirmed from live page data.
  • No clinical trial was located on the exact 500mg berberine HCl + 100mg silymarin combination at this specific ratio, all clinical evidence in this dossier applies to plain berberine HCl at the ingredient level, not to NTD's finished combination formula.
  • NTD's specific claim that its silymarin pairing allows 'lower effective doses than standalone berberine' is not backed by a located head-to-head clinical comparison; NTD's own instructed dose (1500mg/day berberine) is identical to the classic Yin 2008 trial dose, not lower.
  • A currently valid, named third-party GMP certificate/registrar for NTD's Tempe, AZ manufacturing facility was not independently located in this pass beyond the vendor's own transparency-page assertion.
  • Whether Nootropics Depot currently ships this product to EU customers, and under what claims/labelling, was not directly confirmed on the vendor site; this matters given the EU's 2025 decision not to authorize the berberine HCl + silymarin combination as a novel food.
Important to know
BerberineStandard berberine has ~5% oral bioavailability. Dihydroberberine and berberine phytosomes absorb better. Split doses across meals (500 mg × 3) to avoid GI upset.

Editorial notes

Best-priced published-purity berberine. Take 3× daily to hit trial dose.

Go deeper

Where this sits

Actives inside
Berberine
Category
See all in Metabolic →
Ranking
See top 10 Berberine supplements →
Brand
Nootropics Depot profile →
Add to compare Visit brand site →
Brand owners

Spot an error?

If you are the manufacturer or brand owner of Berberine HCl 500 mg and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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