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Thorne HealthTech

Curcumin Phytosome (formerly Meriva 500-SF)

Antioxidant · Capsule · 60 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving
Curcumin 1,000 mg
Form
Capsule
List price (catalog, USD)
$36.00
Price per serving
$0.60List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
Servings per container
60
Catalog monthly estimate
$18.00
Testing disclosure
Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Curcumin1,000 mg

What to check on the label

  • Whether the milligrams describe the whole extract or the standardised compound (for example '500 mg turmeric extract' versus '475 mg curcuminoids').
  • Delivery wording such as liposomal or phytosome changes the carrier, not the labelled amount.
  • For glutathione and sulforaphane, check whether the label lists the compound itself or a precursor (glucoraphanin, NAC).

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

5.3/10
Overall score
#14 / 25 in Antioxidant

Tested by independent lab, top 11% value.

Read the evidence (3 studies)
Add to compareVisit brand site →
Watch out
Tier 2
Product RCT (not peer-reviewed)
Product-specific RCT exists but was not peer-reviewed.
See the 3 supporting studies
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 7.2 of 10. Primary ingredient is Curcumin (evidence grade B). It delivers 1000 mg, inside the studied range of 500–2000 mg. Read the rule → 7.2
Transparency (20%) Why 8.0 of 10. Earned points for independent third-party testing and all doses disclosed. Lost points for no public certificate of analysis. Read the rule → 8.0
Value (10%) Why 9.3 of 10. One day at the trial dose costs about $0.60. That is one of the cheaper options in the catalog (76 of 313 by cost per effective day). Read the rule → 9.3
Formulation (10%) Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule → 5.0 Default. No absorption data on file.
Safety (5%) Why 7.0 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 7.0
Community sentiment (5%) Why 7.0 of 10. Sentiment across 10 external review source(s) is mixed to positive. Community is a signal about daily use, not proof of effect. Read the rule → 7.0
Composite How this 5.3 is built. 0.50 × 7.2 + 0.20 × 8.0 + 0.10 × 9.3 + 0.10 × 5.0 + 0.05 × 7.0 + 0.05 × 7.0 = 5.3 out of 10. Safety caps applied after. 5.3
5.3 composite
Dose vs. studies50%7.2
Transparency20%8.0
Value10%9.3
Formulation10%5.0
Safety5%7.0
Community5%7.0

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

5.3 / 10
Best for
Full trial dose, Budget-friendly
Avoid if
No public lab certificate
Full-dose status
Meets trial dose
Price/month
$18
COA status
Not public
Biggest caveat
No public lab certificate available for independent verification.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $36.00
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context

Our summary

Thorne's Curcumin Phytosome uses the Meriva curcumin-phosphatidylcholine complex (Indena S.p.A.), one of the more clinically studied curcumin delivery formulations, and this dossier's evidence review places it among the stronger cases in this comparison set: a peer-reviewed pharmacokinetic study found roughly 29-fold higher blood curcuminoid exposure versus unformulated curcumin, and two Belcaro-group RCTs at the exact branded complex and a matching 1 g/day total dose found substantial WOMAC osteoarthritis symptom improvements sustained over 3 and 8 months. These are genuine Tier 2 findings, on the exact ingredient complex, at a comparable dose, rather than merely ingredient-category extrapolation, which is unusual for a supplement in this catalog. That said, the clinical trial series is concentrated among a small, overlapping group of investigators with unclear disclosure of Indena's own funding role, and one reported biomarker value (a baseline CRP of ~168 mg/L) is unusually high for typical osteoarthritis patients and could not be independently reconciled from available abstracts. The product carries a genuine, independently audited NSF Certified for Sport mark, a meaningfully stronger quality signal than most products in this catalog, though no independent lab has published potency-verification data for this specific finished capsule.
In plain language

Why this scored this way

This Thorne HealthTech Curcumin Phytosome (formerly Meriva 500-SF) scores 7.3, making it a mid-tier product with both strengths and weaknesses. It delivers 1000mg of Curcumin, inside the studied range of 500–2000mg with grade B evidence (promising human data, not yet comprehensive).

What drives the score up

  • Dose-evidence score of 7.2 shows decent alignment with trial doses.
  • Tested by independent lab (transparency 8.0).
  • Curcumin is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

  • No public lab certificate available for independent verification.

Why you'd choose it

  • You want good value at $0.60/day.
  • You want Curcumin from a Thorne HealthTech product.
  • You want a tested by independent lab product.

Why you might skip it

  • You want a product with a publicly available CoA.
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Curcumin

Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.

4 landmark RCTs · US: GRAS · EU: Food supplement
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$0.60/day at trial dose
What one effective daily dose actually costs
Transparency
8.0/10 · No public lab certificate
Independent batch testing confirmed
Consumer signals
6,839 reviews across platforms · 4.5/5 · high confidence
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

!
Review advised
curcumin dose 1000 mg exceeds UL (210 mg); curcumin: CYP3A4 interactions
Safety signals
Exceeds upper intake limit — curcumin
1000.0 mg per serving exceeds the tolerable upper intake level of 210.0 mg/day. EFSA Acceptable Daily Intake (ADI) is 3 mg/kg bw/day (≈210 mg/day for a 70 kg adult); FDA GRAS notifications support up to 1,000 mg/day, and short-term trials have used 8-12 g/day safely for up to 3 months.
Read more
Liver safety signal — curcumin
Cases of drug-induced liver injury associated with curcumin/turmeric supplements have been reported. Most involved formulations with enhanced bioavailability (phytosome, nanoparticles) or doses above 1,000 mg/day. EFSA set an ADI of 3 mg/kg bw/day (≈210 mg/day for 70 kg). Doses up to 1,000 mg/day of standard extracts have been generally tolerated in trials.
Read more
Drug interaction risk — curcumin
Inhibits CYP2C9 and CYP3A4 (moderate effects on CYP2B6, CYP1A2, CYP2D6). Interacts with warfarin and other vitamin K antagonists (elevated INR reported), NSAIDs, antiplatelet agents, antihyperlipidemics, and reduces iron absorption via chelation.
Read more
Safety flag
curcumin dose 1000 mg exceeds UL (210 mg); curcumin: CYP3A4 interactions
Dose or interaction risk detected. See ingredient page for details.
No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
Buyer complaints
Trustpilot: unresponsive customer service; Trustpilot: shipping delays cited by 69% of one-star reviews
Recurring themes from consumer review platforms.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Curcumin1000 mgEvidence B

Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.

Read about Curcumin →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$36
per bottle · 60 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$0.60
what one effective daily dose costs
$ / g active
$0.60
per gram of active substance
Independently checked

Data verification

COA status
Not public
Evidence grade
B
Per-ingredient breakdown
BCurcumin

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Curcumin
Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.
Belcaro et al. 2010Mohseni et al. 2025 (Frontiers in Nutrition)Bahari et al. 2025 (Inflammopharmacology)
1000 mg 100% of trial dose
1000 mg
3.5 /5
High confidence
6,839 reviews across 3 platforms (3 sources)
Source diversity: 69%
AmazonRedditTrustpilot
Praiseeffective anti-inflammatorypain relief for joints
Complaintsunresponsive customer serviceshipping delays cited by 69% of one-star reviews
Last checked: 2026-08-20

Consumer signals

4.49 out of 5 across 6,839 verified reviews on 4 platforms.

High confidence

Consumer sentiment compiled from 3 public sources.

Trustpilot

39 reviews · 2.1/5 · negative sentiment

Complaintsunresponsive customer serviceshipping delays cited by 69% of one-star reviews
Themes

Thorne's brand-level Trustpilot score is poor, driven almost entirely by customer service and shipping complaints rather than product quality.

Compiled from Trustpilot listing located during research; verified at build time.

Amazon

6,800 reviews · 4.5/5 · positive sentiment

Praiseeffective anti-inflammatorypain relief for jointshigh absorption (Meriva form)
Themes

Amazon reviews for Curcumin Phytosome are strongly positive, citing real pain and inflammation relief with roughly 6,800+ reviews at 4.5 stars.

Compiled from Amazon listing located during research; verified at build time.

Reddit

6 threads discussed · positive sentiment

Praisehelps inflammation, e.g. finger/joint pain after climbing
Themes

r/Supplements and r/Biohackers users report consistent anti-inflammatory benefits using Thorne's Meriva-based Curcumin Phytosome.

Compiled from Reddit listing located during research; verified at build time.

Reddit r/Supplements

2 threads discussed · mixed sentiment

Themes

people ask whether Meriva actually beats other curcumin formulations before buying

general Thorne brand skepticism since its 2023 acquisition and R&D team changes

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site
SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, YesNSF certified, Yes
NIH DSLD registered label
DSLD ID 290208, UPC 6 93749 00485 1
Serving size1-2 Capsule(s)
Servings per container30
Supplement Facts panel, verbatim
Meriva1 Gram(s)

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Examine.com, Curcumin page
No affiliate relationship Not a paid placement

Independent evidence-synthesis support for the category-level premise that enhanced-bioavailability curcumin formulations (like this Meriva-based product) are more likely to be clinically effective than unformulated turmeric extract.

Finding: Examine's evidence-based summary generally rates curcumin's evidence for joint pain/osteoarthritis symptom relief as moderate, contingent on using a bioavailability-enhanced formulation such as a phytosome or piperine-combined product rather than plain turmeric powder.
How we use it: Used as independent ingredient-category context supporting the phytosome-formulation rationale, not as product-specific confirmation.
NSF Certified for Sport product registry
No affiliate relationship Paid placement

Independently audited confirmation that this exact product passes NSF's banned-substance and label-accuracy screening, though brands pay for this certification program (a paid but methodologically independent testing/audit model).

Finding: Thorne's Curcumin Phytosome product is listed in NSF's certified-product database confirming current certification status.
How we use it: Used as direct, product-specific quality-certification evidence.
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Reddit r/Supplements consensus threads on Meriva/curcumin phytosome products
No affiliate relationship Not a paid placement

Directionally consistent with the formal evidence base but not a rigorous or independently verifiable data source.

Finding: Informal community discussion generally regards Meriva-based curcumin products, including Thorne's, as among the better-absorbed and better-evidenced curcumin formulations on the market, though without disclosed methodology or systematic sampling.
How we use it: Used only as low-confidence directional color, explicitly labeled Tier C due to lack of disclosed methodology.
Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 2Product RCT (not peer-reviewed)
4 studies mapped
Tier 2Product RCT (not peer-reviewed)
Product-evaluation study on a curcumin phytosome complex in patients with osteoarthritis
Belcaro G, Cesarone MR, Dugall M, et al. · 2010 · Panminerva Medica · n=50 · 1 g/day Meriva (this product's exact branded complex, providing ~200 mg curcuminoids), taken as a single daily dose rather than this product's labeled 2x/day split dosing · 3 months
on this exact productpeer-reviewed
WOMAC osteoarthritis symptom score decreased approximately 58% in the treatment group; C-reactive protein (an inflammation marker) fell from a mean of ~168 mg/L to ~11.3 mg/L.
This is the strongest evidence in this dossier: a peer-reviewed RCT on the exact branded ingredient complex in this product at a comparable total daily dose (though at a different dosing split, once daily vs. this product's labeled twice-daily regimen). The extremely elevated baseline CRP values (168 mg/L is far above typical osteoarthritis inflammation levels) suggest either a highly inflamed subpopulation or a reporting/units issue in the original paper that this dossier could not independently resolve, flagged as a limitation.
Conflicts: Not fully disclosed in the abstract reviewed; Meriva is an Indena S.p.A. proprietary ingredient, and Indena-affiliated or Indena-funded research is common in this ingredient's trial history, a relevant sponsor-proximity consideration even where not explicitly declared
Source →
Tier 2Product RCT (not peer-reviewed)
Product evaluation of a curcumin phytosome complex during extended administration in osteoarthritis patients
Belcaro G, Hosoi M, Pellegrini L, et al. · 2010 · Alternative Medicine Review · n=100 · 1 g/day Meriva (this product's exact branded complex) · 8 months
on this exact productpeer-reviewed
WOMAC score decreased more than 50% from baseline; Karnofsky Performance Status score improved from a mean of 73.3 to 92.2, and use of concomitant NSAID/analgesic medication substantially decreased in the treatment group.
A longer-duration extension of the same research group's earlier trial, again on the exact branded complex at a matching total daily dose, reinforcing the 3-month result with sustained benefit at 8 months, though from the same research group and Indena-linked ingredient lineage as the first trial rather than an independent replication.
Conflicts: Not fully disclosed in the abstract reviewed; same Indena-proximate research lineage as the 2010 3-month trial above
Source →
Tier 2Product RCT (not peer-reviewed)
Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation
Cuomo J, Appendino G, Dern AS, et al. · 2011 · Journal of Natural Products · Single-dose comparison of unformulated curcumin mixture vs. Meriva phytosome-complexed curcumin (this product's exact complex) · Single-dose pharmacokinetic sampling
on this exact productpeer-reviewed
The phytosome-complexed formulation produced approximately 29-fold higher plasma curcuminoid area-under-curve (AUC) exposure than the equivalent dose of unformulated curcumin powder.
This is the bioavailability study underlying the vendor's headline absorption claim; it is a real, peer-reviewed pharmacokinetic trial on the exact ingredient complex, though it measures blood exposure (a surrogate/pharmacokinetic endpoint), not a clinical symptom outcome on its own.
Conflicts: Not fully disclosed in the abstract reviewed; involves Indena-affiliated formulation technology
Source →
Tier 3Ingredient RCT (matching dose)
Efficacy and safety of curcumin and curcumin phytosome complexes: systematic review and meta-analysis
Multiple contributing trials, reviewed in various systematic reviews · 2023 · Various (review context) · Varied across pooled trials · Varied
ingredient-levelpeer-reviewed
Reviews compiling the Meriva/curcumin phytosome osteoarthritis trial data generally characterize the phytosome formulation's evidence base as more consistent than unformulated curcumin's, though still limited to a small number of trials concentrated among overlapping research groups.
Useful as an independent-review lens on how the concentrated Meriva trial literature (mostly from Belcaro and colleagues) is regarded in the broader curcumin research community, it is not itself a new trial and does not resolve the sponsor-proximity limitation of the underlying primary studies.
Conflicts: Not applicable, narrative synthesis
Source →
Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

CurcuminBelcaro et al. 2010
CurcuminMohseni et al. 2025 (Frontiers in Nutrition)
CurcuminBahari et al. 2025 (Inflammopharmacology)
CurcuminKroon et al. 2025 (iScience)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Supported
“Meriva/Curcumin Phytosome delivers up to 29-fold greater bioavailability than unformulated curcumin”
This claim is directly and specifically supported by a peer-reviewed crossover pharmacokinetic study on the exact ingredient complex (Cuomo et al. 2011, PMID 21294203), which found approximately 29-fold higher plasma curcuminoid exposure versus unformulated curcumin. This is one of the more rigorously substantiated bioavailability claims in this comparison set.
Vendor source
Supported
“Supports joint comfort and mobility”
Two RCTs on the exact branded complex at a matching total daily dose (Belcaro et al. 2010, 3-month and 8-month) found substantial WOMAC osteoarthritis symptom score improvements and reduced concomitant pain-medication use. This is genuine product-level clinical support, though tempered by the fact that both trials come from the same overlapping research group and the ingredient manufacturer's (Indena) sponsorship/funding disclosures were not fully available in the reviewed abstracts.
Vendor source
Partial support
“Supports a healthy inflammatory response”
The cited CRP reduction in the Belcaro 2010 trial (from ~168 mg/L to ~11.3 mg/L) is a dramatic result, but the extremely high baseline CRP value is unusual for a general osteoarthritis population and raises a data-interpretation question this dossier could not fully resolve from the available abstract; the finding should be treated as suggestive rather than definitively established until the full paper's methodology can be independently reviewed.
Vendor source
Supported
“NSF Certified for Sport, verified free of banned substances and accurately labeled”
NSF Certified for Sport is a legitimate, independently audited third-party certification program with a public, searchable database of certified products; this is a verifiable, meaningful quality claim distinct from unverifiable brand-level marketing language.
Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • The full-text methodology and funding disclosures of the two Belcaro Meriva osteoarthritis trials (2010 3-month and 8-month studies) were not independently reviewed beyond abstracts in this research pass; the unusually high baseline CRP value reported (~168 mg/L) could not be independently reconciled or explained.
  • Whether Indena S.p.A. (the manufacturer of the Meriva ingredient) directly funded or was otherwise involved in the cited clinical trials is not clearly disclosed in the abstracts reviewed, this is a material sponsor-proximity consideration for a branded-ingredient trial series concentrated among a small number of overlapping investigators.
  • This dossier could not confirm whether Thorne's specific finished capsule (as opposed to the raw Meriva ingredient tested in the cited trials) has itself been independently third-party lab tested for curcuminoid potency by an outlet such as ConsumerLab or Labdoor.
  • The 2023-2024 European regulatory attention to curcumin-supplement-associated rare liver injury case reports was not verified to specifically name this Thorne product or the Meriva ingredient by name, and should be read as category-level regulatory context, not a product-specific safety finding.
  • Long-term (beyond 8 months) safety and efficacy data for daily use of this exact product were not located.
  • Reddit r/Supplements community forum
    mixed sentiment

    Community discussion exists, with positive comments about Meriva’s research and benefits alongside concerns about Thorne’s labeling and formulation clarity. No single Reddit thread is treated as a representative product review.

    no direct URLchecked 2026-08-07
  • Amazon customers aggregator

    An Amazon listing for this exact product was located. The product URL is not retained because marketplace listings can change.

    no direct URLchecked 2026-08-07
Important to know
CurcuminProducts with just 'turmeric extract' and no branded delivery system are not bioavailable. Ask for the specific bioavailability system.

Editorial notes

Uses Indena's well-studied Meriva phytosome, one of the more credible curcumin delivery forms on the market; dose (1g phytosome/day) is mid-range for phytosome-form curcumin products.

Go deeper

Where this sits

Actives inside
Curcumin
Category
See all in Antioxidant →
Brand
Thorne HealthTech profile →
Add to compare Visit brand site →
Brand owners

Spot an error?

If you are the manufacturer or brand owner of Curcumin Phytosome (formerly Meriva 500-SF) and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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