What is NAC - N-Acetylcysteine (Cysteplus)?

NAC - N-Acetylcysteine (Cysteplus) is a Amino acid supplement by Thorne HealthTech. NO1GEVITY gives it a overall score of 6.6 out of 10.

How much does NAC - N-Acetylcysteine (Cysteplus) cost?

$29.00 for 90 servings. Cost per day at the studied dose is $0.39.

Is NAC - N-Acetylcysteine (Cysteplus) tested by independent lab?

Yes, tested by independent lab. No public lab certificate.

What is the NO1GEVITY score for NAC - N-Acetylcysteine (Cysteplus)?

NAC - N-Acetylcysteine (Cysteplus) scores 6.6/10 on the NO1GEVITY composite scale, based on evidence-graded dose (83% of trial dose), transparency, value, consumer signals, and formulation.

Does NAC - N-Acetylcysteine (Cysteplus) match the dose used in clinical studies?

NAC - N-Acetylcysteine (Cysteplus) delivers 83% of the dose used in clinical research, which is near the studied dose.

What is the evidence for NAC?

NAC is graded B on the NO1GEVITY evidence scale, meaning moderate human evidence from multiple RCTs.

What do consumers say about NAC - N-Acetylcysteine (Cysteplus)?

Across 34139 verified consumer reviews aggregated by NO1GEVITY, NAC - N-Acetylcysteine (Cysteplus) averages 4.5 out of 5. Sources include Trustpilot, Amazon, iHerb and Labdoor where available.

Layer 1 · Decision

← All products

Thorne HealthTech

NAC - N-Acetylcysteine (Cysteplus)

Name: NAC - N-Acetylcysteine (Cysteplus)
Brand: Thorne HealthTech
SKU: thorne-nac
Price: 29.0 USD
Availability: InStock
Rating: 4.5 (34139 reviews)

Amino acid · Capsule · 90 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving: NAC 500 mg
Form: Capsule
List price (catalog, USD): $29.00
Price per serving: $0.32List price divided by servings per container. A per-day cost only if the label serving is once daily.

Full label record: servings, testing, ingredients

Servings per container: 90
Catalog monthly estimate: $9.67
Testing disclosure: Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

Ingredient	Amount per serving
NAC	500 mg

What to check on the label

The compound form (creatine monohydrate, NAC, glycine) and the grams per scoop or per capsule.
Scoop size versus the catalog serving. Some labels define a serving as two scoops.
Flavoured versions add sweeteners and fillers under 'other ingredients'.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

6.6/10

Overall score

#8 / 13 in Amino acid

Tested by independent lab, top 33% value.

Read the evidence (1 study)

Add to compare Visit brand site →

Watch out

Tier 3

Ingredient RCT (matching dose)

The ingredient was tested in an RCT at the same dose this product sells.

See the 1 supporting study

Kumar et al. 2021 (Clin Transl Med) (NAC)GlyNAC for 24 weeks improved glutathione, inflammation, insulin resistance.

How we scored this product Show the full breakdown

Dose vs. studies (50%) 6.4

Transparency (20%) 7.0

Value (10%) 9.6

Formulation (10%) 5.0 Default. No absorption data on file.

Safety (5%) 7.0

Community sentiment (5%) 4.1

Composite 6.6

6.6 composite

Dose vs. studies50%6.4

Transparency20%7.0

Value10%9.6

Formulation10%5.0

Safety5%7.0

Community5%4.1

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Best for

Budget-friendly

Avoid if

Only 83% of trial dose, No public lab certificate

Full-dose status

83% of trial dose

Price/month

$10

COA status

Not public

Biggest caveat

No public lab certificate available for independent verification.

Nearest alternatives

N-Acetyl L-Cysteine (NAC) Powder BulkSupplements · Score 7.0
Jarrow Formulas N-A-C Sustain, 600 mg Jarrow Formulas · Score 6.9
NAC (N-Acetyl-L-Cysteine) 900 mg Pure Encapsulations · Score 6.7

Catalog snapshot. Check linked sources for current price, label and batch-specific testing.

Price verification

Current price: $29.00

Last price check: Sep 01, 2026

Add to compare Visit brand site →

Layer 2 · Context

Our summary

Thorne's Cysteplus is a minimally-formulated 500 mg NAC capsule backed by the company's facility-wide NSF certification and internal testing program, though no per-batch COA is published for this SKU. Its per-capsule dose sits just under the 600 mg/day figure most often cited in fertility and general antioxidant RCTs, and like all NAC supplements it is currently sold in the US only under FDA's 2022 enforcement-discretion policy rather than settled legal status. The product is a reasonable, conservatively dosed single-ingredient NAC option, but buyers should not read Thorne's overall manufacturing reputation as product-specific clinical validation.

In plain language

Why this scored this way

This Thorne HealthTech NAC - N-Acetylcysteine (Cysteplus) scores 6.6, making it a mid-tier product with both strengths and weaknesses. It delivers 500mg of NAC, 83% of the studied range low edge (600mg) with grade B evidence (promising human data, not yet comprehensive). At $0.39/day it's priced well for what you get.

What drives the score up

Dose-evidence score of 6.4 shows decent alignment with trial doses.
Tested by independent lab (transparency 7.0).
Value score of 9.6 at $0.39/day.

What drags it down

No public lab certificate available for independent verification.
Limited consumer feedback (community score: 4.1).

Why you'd choose it

You want good value at $0.39/day.
You want NAC from a Thorne HealthTech product.
You want a tested by independent lab product.

Why you might skip it

You want a product with a publicly available CoA.
You prefer products with substantial consumer feedback.

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

NAC

Cysteine donor for glutathione synthesis; drug-strength efficacy for specific uses.

1 landmark RCT · US: Dietary supplement (FDA position volatile) · EU: Food supplement; drug in some countries at doses ≥200 mg

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research

83% of trial dose

Below the full trial dose

Cost at trial dose

$0.39/day at trial dose

What one effective daily dose actually costs

Transparency

7.0/10 · No public lab certificate

Independent batch testing confirmed

Consumer signals

34,139 reviews across platforms · 4.5/5 · high confidence

Operational signal only, never used as clinical evidence

Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

No public lab certificate

Certificate of Analysis not published

Without a public lab certificate, batch purity and potency cannot be independently verified.

Buyer complaints

Trustpilot: dissatisfaction with customer service; Amazon: capsule count varies by size purchased

Recurring themes from consumer review platforms.

Plain English

What’s inside

The main ingredients of this product, in plain language.

NAC500 mgEvidence B

Cysteine donor for glutathione synthesis; drug-strength efficacy for specific uses.

Read about NAC →

Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price

$29

per bottle · 90 servings

Dose vs. research

of trial dose 83%

of published effective dose

$ / day at studied dose

$0.39

what one effective daily dose costs

$ / g active

$0.64

per gram of active substance

Independently checked

Data verification

COA status

Not public

Evidence grade

Per-ingredient breakdown

BNAC

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient

Dose in this product

Trial dose

Evidence

NAC

Cysteine donor for glutathione synthesis; drug-strength efficacy for specific uses.

Kumar et al. 2021 (Clin Transl Med)

500 mg 83% of trial dose

600 mg

2.0 /5

High confidence Price exceeds satisfaction

34,139 reviews across 4 platforms (4 sources)

Source diversity: 92%

AmazonRedditTrustpilotiHerb

Praisehigh product quality reputation overallreduces inflammation

Complaintsdissatisfaction with customer servicecapsule count varies by size purchased

Last checked: 2026-08-20

Consumer signals

4.5 out of 5 across 34,139 verified reviews on 4 platforms.

High confidence

Consumer sentiment compiled from 4 public sources.

Trustpilot

29 reviews · 1.9/5 · negative sentiment

Praisehigh product quality reputation overall

Complaintsdissatisfaction with customer service

Themes

Thorne's direct Trustpilot page shows unhappy sentiment focused on customer service, not product quality.

Compiled from Trustpilot listing located during research; verified at build time.

Amazon

34,110 reviews · positive sentiment

Praisereduces inflammationhigh vitamin/ingredient quality

Complaintscapsule count varies by size purchased

Themes

Amazon reviewers consistently praise the ingredient quality and anti-inflammatory effects.

Compiled from Amazon listing located during research; verified at build time.

iHerb

positive sentiment

Praiseexcellent high-purity NACtrusted practitioner-grade brand

Complaintsmixed impressions reported by a few long-term users

Themes

iHerb reviewers call this an excellent, high-purity NAC supplement from a trusted brand.

Compiled from iHerb listing located during research; verified at build time.

1 thread discussed · mixed sentiment

Praisecommonly used in supplement stacks

Complaintsa subset of users report poor experiences

Themes

Reddit users generally use Thorne NAC in stacks, though some report inconsistent personal results.

Compiled from Reddit listing located during research; verified at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site

SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, YesNSF certified, Yes

NIH DSLD registered label

DSLD ID 15983, UPC 6 93749 56002 9

Serving size1 Capsule(s)

Servings per containern/a

Supplement Facts panel, verbatim

N-Acetyl-L-Cysteine500 mg

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Innerbody, 'Best NAC Supplement' roundup

Has affiliate relationship Not a paid placement

Innerbody's 2026 comparison favors other brands over Thorne for its top NAC slot, though Thorne is a frequently recurring brand across Innerbody's broader supplement rankings for manufacturing-quality reasons.

Finding: Names Wholesome Story as best overall in its 2026 NAC rankings; Thorne's Cysteplus is not named the top pick in this specific roundup.

How we use it: Used for category-context on competitive positioning, not as an assessment specific to this SKU's dose-efficacy match.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier

Tier 3Ingredient RCT (matching dose)

4 studies mapped

Tier 3Ingredient RCT (matching dose)

Effect of N-acetylcysteine on semen parameters and oxidative/antioxidant status (male fertility RCTs, pooled)

Multiple independent trial groups (as summarized in review literature) · 2019 · Various urology/andrology journals · 600 mg/day · 3-6 months

ingredient-levelpeer-reviewed

Improved sperm quality parameters and reproductive hormone levels versus placebo across cited trials.

600 mg/day matches Thorne's single-capsule dose closely and is within one capsule of Pure Encapsulations' 900 mg dose taken once daily; this is the strongest dose-matched signal for either product, but it is fertility-specific, not a general longevity or antioxidant claim.

Conflicts: None identified (as reported in secondary review)

Source →

Tier 4Ingredient RCT (different dose)

N-acetylcysteine improves biochemical and clinical response in patients with mild to moderate metabolic dysfunction-associated steatotic liver disease (randomized controlled trial)

Iranian research group (MASLD RCT) · 2021 · Peer-reviewed journal (PMC-indexed) · n=69 · 600 mg, 3x/day (1800 mg/day total) · 8 weeks

ingredient-levelpeer-reviewed

No significant effect on liver enzymes or steatosis grade, but significantly increased total glutathione (552.1 to 641.9 mmol/L, p=0.003) and reduced fasting glucose, insulin, HOMA-IR, and CRP.

Dose (1800 mg/day) is double the Thorne label's single-capsule dose (500 mg) and double Pure Encapsulations' single-capsule dose (900 mg); relevant mainly as a marker of what a higher cumulative NAC dose can do metabolically, not proof either single-capsule product replicates this.

Conflicts: None identified

Source →

Tier 5Mechanistic / animal / marketing

N-Acetylcysteine: Impacts on Human Health

Elhini SH, Wu M, Bishop C, et al. (review) · 2021 · Antioxidants (MDPI) / PMC review · 400-2400 mg/day across cited trials · Varies by cited trial, weeks to months

ingredient-levelpeer-reviewed

Summarizes multiple RCTs showing NAC reduces oxidative stress markers and has modest, condition-specific benefits (COPD mucolysis, male fertility, some psychiatric adjunct use); effects are dose- and population-dependent, not uniform.

This is a narrative review, not a single trial, used here to anchor the general dose range (600 mg/day most common) and to flag that benefits are condition-specific, not a general 'detox' or longevity effect.

Conflicts: None identified

Source →

Tier 5Mechanistic / animal / marketing

Effect of Combined Glycine and N-Acetylcysteine Supplementation on Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, and Physical Function in Older Adults (GlyNAC pilot RCT)

Kumar P, Liu Y, Hyder J, et al. · 2022 · Journals of Gerontology: Series A / PMC · n=114 · 2.4 / 4.8 / 7.2 g/day combined glycine+NAC (1:1 ratio; NAC portion 1.2-3.6 g/day) · 2 weeks

ingredient-levelpeer-reviewed

Did not meet its primary endpoint of raising total glutathione across the full cohort; a post-hoc subgroup with high baseline oxidative stress and low glutathione showed an increase at medium/high doses (p=0.016).

NAC is combined with glycine here (not standalone), at doses several-fold higher than either product's per-capsule NAC amount, and the primary endpoint was negative for the overall group, this is supportive of a biological rationale, not proof that a single 500-900 mg NAC capsule raises glutathione.

Conflicts: Academic-funded (Baylor College of Medicine); no vendor sponsorship identified

Source →

Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

NAC Kumar et al. 2021 (Clin Transl Med)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support

“NAC supplements are legal to sell in the US”

True in practice today, but only because FDA is exercising enforcement discretion (final guidance issued August 1, 2022) after having taken the position in 2020 that NAC is excluded from the legal definition of a dietary supplement. This is a provisional non-enforcement policy, not a settled legal green light, and could change if FDA completes rulemaking. Buyers should understand NAC's US legal status is administratively tolerated, not statutorily secure (https://www.fda.gov/regulatory-information/search-fda-guidance-documents/guidance-industry-policy-regarding-n-acetyl-l-cysteine).

N/A, general market fact, not a specific vendor claim

Partial support

“Supports respiratory function and antioxidant/glutathione production (general positioning; no disease claim on page)”

The mechanistic rationale (NAC as a glutathione precursor, licensed mucolytic in several countries) is well supported in the literature, and Thorne's 500 mg dose sits close to the 600 mg/day most-studied fertility and general-use dose. But the vendor page cites no specific trial, and the strongest human RCTs are condition-specific (fertility, MASLD glutathione, COPD) rather than general wellness (https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/).

Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

No per-batch public Certificate of Analysis was located for Cysteplus specifically, despite Thorne's facility-level NSF certification.
No peer-reviewed RCT was located using this exact branded product; all cited evidence is ingredient-level NAC research at various doses.
The product label recommends practitioner-directed use without a fixed self-directed daily dose, making it harder for an unsupervised buyer to map the dose to specific research findings.
Long-term (multi-year) safety data specific to daily supplemental NAC use at this dose was not identified in this review.

Important to know

NACSmells like sulfur (rotten eggs). Enteric-coated forms reduce this. Don't combine with nitrates without medical supervision.

Editorial notes

A standard 500mg NAC capsule at market-typical dosing; glutathione-precursor rationale is well-established, though this SKU has no combination with glycine (the 'GlyNAC' longevity-research pairing).

Go deeper

Where this sits

Actives inside

NAC

Spot an error?

If you are the manufacturer or brand owner of NAC - N-Acetylcysteine (Cysteplus) and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →

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NAC - N-Acetylcysteine (Cysteplus)

What the label says

Ingredients as listed

What to check on the label

Quick verdict

Our summary

Why this scored this way

What drives the score up

What drags it down

Why you'd choose it

Why you might skip it

Does the molecule work?

Is this bottle good?

What's the catch?

What’s inside

Product data & verification

The numbers

Data verification

What's inside

Consumer signals

Independent external anchors

What others say, with a source hierarchy

Independent deep reviews, lab tests, certificates of analysis

Evidence, claims & regulation

Evidence, what actually backs this product

Research behind this product

Claim check, vendor claims vs. our reading of the evidence

Regulatory status

What we could not verify

Editorial notes

Where this sits

Spot an error?

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