Label snapshot
What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.
| Ingredient | Amount per serving |
|---|---|
| Urolithin A | 500 mg |
Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.
These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.
Full trial dose, tested by independent lab.
Read the evidence (2 studies)Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.
This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.
This Timeline Nutrition Mitopure® Softgel scores 8.6, making it one of the highest-scoring products on the site. It delivers 500mg of Urolithin A, inside the studied range of 500–1000mg with grade A evidence (strong human trial data). At $4.33/day it's among the more expensive options in Mitochondrial.
The science behind each active ingredient, independent of which brand sells it.
A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.
The specific product: dose, price, transparency, and what buyers report.
Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.
The main ingredients of this product, in plain language.
A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.
Read about Urolithin A →Hard numbers and independently checked status. Expand each block for its source.
All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.
Consumer signals gathered from 5 platforms.
Medium confidenceConsumer sentiment compiled from 3 public sources (Cell Reports Medicine (Singh 2022), Nature Metabolism (Andreux 2019), Trustpilot).
positive sentiment
Peer-reviewed Nature study showed Mitopure® induces mitophagy in humans at 500 and 1000 mg.
Compiled from a Nature Metabolism (Andreux 2019) listing located during manual research; not independently re-verified against the live page at build time.
positive sentiment
Replication RCT: 4 months of 500/1000 mg improved muscle endurance in older adults.
Compiled from a Cell Reports Medicine (Singh 2022) listing located during manual research; not independently re-verified against the live page at build time.
7 reviews · 4.2/5 · mixed sentiment
Compiled from a Trustpilot listing located during manual research; not independently re-verified against the live page at build time.
4,485 reviews · 4.5/5
1,114 reviews · 4.5/5
These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.
Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.
SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.
We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.
These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.
Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.
Innerbody concludes Mitopure is a 'research-supported' urolithin A product with a genuinely favorable safety record (citing a 2024 systematic review finding no serious adverse events across studies) and plausible benefits for mitochondrial/muscle health, but flags the price as high relative to competing products.
ConsumerLab's free summary takes a notably more cautious tone than Timeline's own marketing, characterizing the muscle-health evidence base as showing only 'limited benefit,' and separately notes that some marketed urolithin A brands have been subject to a federal manufacturing/sales ban for quality violations.
lifespan.io frames urolithin A as a legitimate, mechanistically interesting mitochondrial-health compound with 'positive results' in early human trials, describing it as part of the broader academic longevity research landscape rather than reviewing Timeline as a commercial product per se.
Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.
Independent Trustpilot reviewers report a substantially less favorable experience than the vendor's own review page, with recurring complaints about lack of noticeable results after 3+ months and hundreds of dollars spent, and difficulty with subscription cancellation/refunds.
Mood indicator only. We never use aggregate stars as evidence of efficacy.
Overwhelmingly positive self-hosted review aggregate, though several visible negative reviews cite lack of noticeable effect, high price, and customer-service/shipping issues.
Additional public mentions we located, kept separate from the deep independent reviews above.
Peer-reviewed Nature study showed Mitopure® induces mitophagy in humans at 500 and 1000 mg.
Replication RCT: 4 months of 500/1000 mg improved muscle endurance in older adults.
4.2/5. Positive for effect; users note the price point.
Published evidence, claim checks, regulatory status and what could not be verified.
Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.
The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.
Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.
Rules change often. We record when we last verified each row. See the full regulatory timeline →
We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.
This is a brand-level customer-service profile for timeline; it does not isolate Mitopure® Softgel.
Community discussion exists around Mitopure Softgel, with some users reporting improved muscular endurance while others questioning whether it works. No single Reddit thread is treated as a representative product review.
Timeline displays first-party softgel reviews on its public page.
Patented Mitopure® ingredient. Two softgels/day = 500 mg. Full 1000 mg trial dose costs ~$130/mo.
If you are the manufacturer or brand owner of Mitopure® Softgel and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.
We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.
Request a correction →The next highest-scoring products in Mitochondrial, same scoring method, same rules.
ProHealth LongevityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
DoNotAgeStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Double Wood SupplementsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Timeline NutritionStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Timeline NutritionStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.