A willow bark compound with mild mTOR-modulating and anti-inflammatory activity; sometimes called a natural rapamycin analog.
Interesting as a mild natural mTOR modulator, but the evidence is far weaker than for rapamycin. Low risk at typical doses. Long-term safety data is limited.
Salicin (Salicin (Willow Bark Extract)) is a natural rapalog / anti-inflammatory with evidence grade D, meaning it is primarily supported by animal studies. We track 1 products containing Salicin. Typical doses range from 100 to 100 mg per serving. The top-ranked product scores 4.7 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $49.00 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Natural Rapalogs | Supersmart | 100 mg | $49.00 | No | 4.7 |
Scores are editorial judgments, not a scientific standard. See how we score.
Salicin is the active compound in willow bark, the natural precursor to aspirin. Some researchers classify it as a natural rapalog because it appears to modulate mTOR signaling, the same pathway targeted by rapamycin.
Willow bark has been used for anti-inflammatory purposes for centuries. The mTOR connection is primarily mechanistic and animal-based. No human trials on longevity endpoints exist.
Interesting as a mild natural mTOR modulator, but the evidence is far weaker than for rapamycin. Low risk at typical doses. Long-term safety data is limited.
2-(Hydroxymethyl)phenyl-beta-D-glucopyranoside. A phenolic glycoside from Salix species. Metabolized in vivo to salicylic acid. Also shows partial mTORC1 inhibition in cell studies.
In vitro studies show salicin and its derivatives inhibit mTORC1 signaling, though weakly compared to rapamycin. Human data is limited to anti-inflammatory analgesic studies. No longevity outcome data.
Salicylic acid half-life 2 to 4 hours; parent compound metabolized rapidly.
Do not combine with NSAIDs or blood thinners. Some people are allergic to salicylates. Quality varies between willow bark extract suppliers.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for Salicin, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
Systematic review: willow bark extract equivalent to 120 to 240 mg salicin showed modest analgesic efficacy in low-back pain RCTs.
Read study →All products in our catalog that contain Salicin, ranked by our overall score. Ranking is editorial, never paid.
SupersmartMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside Salicin in our catalogue.
See Salicin in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View Salicin on the Longevity Map →Salicin is the active compound in willow bark, the natural precursor to aspirin. Some researchers classify it as a natural rapalog because it appears to modulate mTOR signaling, the same pathway targeted by rapamycin.
The trial dose in published human studies is 100 mg per day, with a range of 60 to 240 mg per day. Always consult a qualified clinician before starting any supplement.
Do not combine with NSAIDs or blood thinners. Some people are allergic to salicylates. Quality varies between willow bark extract suppliers.
We track 1 products containing Salicin. The top-ranked product scores 4.7 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
Salicin has evidence grade D, meaning it is primarily supported by animal studies. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.