Basics: short version, verdict first People Molecules Peptides Biomarkers Studies Stem Cells Editorial Methodology
← All ingredients
Mitochondrial

Urolithin A · Urolithin A

A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.

A
Evidence grade
Replicated human RCTs with hard endpoints

Short answer

The strongest evidence in the field right now. Missing from most 'longevity stacks' because it's expensive and patented, Timeline Mitopure® is the only serious supplier of the licensed compound.

Product and dose overview

Urolithin A (Urolithin A) is a mitochondrial with evidence grade A, meaning it is well-supported by replicated human trials. We track 9 products containing Urolithin A. Typical doses range from 300 to 1000 mg per serving. The top-ranked product scores 8.6 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $130.00 per month.

Evidence grade: A Products in database: 9 Category: Mitochondrial

Top Urolithin A products

ProductBrandDosePrice/mo3rd-party testedScore
Mitopure® SoftgelTimeline Nutrition500 mg$65.00Yes8.6
Full Spectrum Urolithin A - 60 capsulesProHealth Longevity500 mg$55.97Yes8.6
Urolithin-A Liposomal 1,000mgPerpetua Life1000 mg$59.00Yes8.4
Mitopure® PowderTimeline Nutrition1000 mg$130.00Yes8.2
Timeline Mitopure Gummies (Urolithin A, Strawberry)Timeline Nutrition500 mg$125.00Yes8.1

Scores are editorial judgments, not a scientific standard. See how we score.

What it is

A molecule your gut bacteria make from pomegranate and berries, if you have the right bacteria. Only about 40% of people do. Urolithin A tells old, damaged mitochondria (the power plants inside cells) to recycle themselves, so cells work better.

Why people take it

The first human trials showed urolithin A is safe and activates mitophagy. A 4-month trial in adults 40 to 65 reported around 12% more leg strength, but that was a secondary measure; the primary endpoint was not met, and a later endurance trial in older adults also missed its primary endpoints. Human evidence is still early.

Our verdict

The strongest evidence in the field right now. Missing from most 'longevity stacks' because it's expensive and patented, Timeline Mitopure® is the only serious supplier of the licensed compound.

Structure & class

6H-dibenzo[b,d]pyran-6-one derivative produced by gut microbiota from ellagitannins in pomegranate/walnuts/berries.

Mechanism & clinical data

Andreux et al. 2019 (Nature Metabolism, NCT03464500) confirmed mitophagy induction and safety at 500 and 1000 mg. Singh et al. 2022 (Cell Reports Medicine) reported ~12% leg strength gains in adults 40 to 65 at 1000 mg/day, but the primary endpoint (peak power) was not significantly improved. Liu et al. 2022 (JAMA Network Open, NCT04160312, N=66, ages 65 to 90) found no significant improvement in 6-minute walk distance or muscle ATP.

Pharmacokinetics

8 to 17 hours (systemic exposure after single dose).

Dose & forms

Trial dose
1000 mg
/ day
Range in trials
500 to 1000 mg
/ day
Common forms
Softgel (Mitopure®), Powder, Gummy

What to watch out for

Cheap 'urolithin A precursor' products (pomegranate extract) don't work if you lack the right gut bacteria. Only direct Urolithin A supplements are reliable.

Safety limits and interactions

When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.

Safety note
No formal UL. FDA granted a GRAS no-objection letter in 2018; well tolerated in trials at doses up to 1,000 mg/day for 4 months.

Source: https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Urolithin_A_UPDATE_(supplement).pdf

Where this dose comes from

The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.

When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.

Regulatory status

EUAuthorised Novel Food (EU 2021/85)
USFDA GRAS
UKAuthorised
CANHP licensed

Timeline

Regulatory events, evidence grade changes, and key research milestones for Urolithin A, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.

  • 2025-04 Regulatory single source
    EU Court sharpens the bar for botanical health claims
    A Court of Justice of the European Union ruling in April 2025 further tightened the requirements for how botanical ingredients (herbs, plant extracts) can be marketed with health claims in the EU, effectively removing much of the flexibility of the on-hold list.
  • 2024-06 Regulatory confirmed
    EU report identifies 117 supplement substances as potential health risks
    The HoA Working Group on Food Supplements (26 European countries) published its first report evaluating 117 substances used in food supplements. Of these, 65 were assessed as likely novel foods, 6 were already regulated, 34 had insufficient data, and 12 were prioritized for Article 8 restriction under Regulation (EC) No 1925/2006. The 12 priority substances include ashwagandha, curcumin, melatonin, piperine, St. John's wort, coumarin, p-synephrine, maca, holy basil, Melaleuca, black cohosh, and L-tryptophan. The report drew on 1,500 RASFF alerts reviewed between 2017 and mid-2022.
    Source →
  • 2022-06 Regulatory confirmed
    EFSA opinion clears urolithin A as a novel food
    The European Food Safety Authority issued a positive scientific opinion on urolithin A (as sold by Amazentis / Timeline) as a novel food ingredient, subject to specified conditions of use. This is what allowed Mitopure to be sold in the EU.
    Source →
  • 2022 Research milestone
    Singh et al. 2022 (Cell Reports Medicine)
    4 months at 1000 mg/day in adults 40 to 65: primary endpoint (peak power output) not significantly improved; ~12% leg strength gain was a secondary outcome.
    Source →
  • 2021-03 Regulatory confirmed
    EFSA opinion clears urolithin A as a novel food
    EFSA published a positive safety opinion on urolithin A as a novel food, supporting its authorization for use in food supplements. The opinion assessed safety, bioavailability, and manufacturing specifications.
    Source →
  • 2019 Research milestone
    Andreux et al. 2019 (Nature Metabolism)
    First-in-human study confirmed mitophagy induction and safety at 500 and 1000 mg.
    Source →
  • 2006-12 Regulatory confirmed
    EU Health Claims Regulation adopted
    Regulation (EC) No 1924/2006 laid down harmonised rules for nutrition and health claims made on foods, including supplements. Only claims listed in the EU Register of authorised claims can be used. Rejected botanical claims are held in a separate on-hold list.
    Source →
  • 1997 Regulatory confirmed
    EU introduces the Novel Food Regulation
    Regulation (EC) No 258/97 required any food or food ingredient without a history of consumption in the EU before 15 May 1997 to be authorised before being placed on the market. This is the framework that captures NMN, spermidine as a supplement ingredient, urolithin A, and many other longevity actives.
    Source →
Tolerability data

Reported adverse events

Consumer reports submitted to an official government adverse-event database. These reports mention this ingredient but do not prove it caused the reaction. Report volume reflects market penetration as much as inherent risk.

2
total reports
Low report volume
Blood Pressure Abnormal
1
Chills
1
Dehydration
1
Depressed Mood
1
Emergency Care
1
Liver Disorder
1
Nausea
1
Nervous System Disorder
1
Data source

Retrieved from the FDA Adverse Event Reporting System (CAERS) via the openFDA API. Verified 2026-08-06. Reports are voluntary consumer submissions and mandatory serious-event filings. They establish surveillance, not causality.

2026 evidence refresh

Urolithin A is a gut-bacteria metabolite of pomegranate ellagitannins that activates mitophagy and modestly boosts muscle strength.

Verified 2026-08-06. We update this section as new peer-reviewed trials land.

Human RCT base
8
peer-reviewed randomised trials
Largest single trial
n = 88
500 mg and 1000 mg urolithin A both increased leg muscle strength by about 10-12% versus placebo in overweight middle-aged adults; the primary endpoint, peak power output, did not reach significance. source

Best-supported claim

Anurag Singh, Davide D'Amico, and colleagues at Amazentis ran the ATLAS trial, a randomized, placebo-controlled study in 88 overweight, low-endurance middle-aged adults given 500 mg or 1000 mg of urolithin A (Mitopure) daily for 4 months (https://pmc.ncbi.nlm.nih.gov/articles/PMC9133463/). Leg muscle strength rose about 10 to 12% at both doses versus placebo, plasma acylcarnitines and C-reactive protein fell, and skeletal muscle biopsies showed increased mitophagy-related protein expression. A 2024 systematic review by researchers pooling five studies and 250 participants confirmed urolithin A consistently increases muscle strength and endurance and lowers inflammation, but found no effect on maximal ATP production, mitochondrial biogenesis, body composition, or physical function tests (https://pubmed.ncbi.nlm.nih.gov/39002645/).

Not supported by the evidence base

Urolithin A is marketed as a comprehensive anti-aging compound for brain, skin, muscle, and cellular energy. Human RCT evidence supports only a narrow slice of this: modest muscle strength and endurance gains, plus some anti-inflammatory markers. The 2024 systematic review explicitly found no effect on mitochondrial ATP production, biogenesis, or overall physical function tests, despite marketing language about 'boosting mitochondrial health' (https://pubmed.ncbi.nlm.nih.gov/39002645/). A 2026 review states plainly that no completed human trial has evaluated cognitive or neurodegenerative disease outcomes, so brain-health claims rest on mouse data alone (https://pubmed.ncbi.nlm.nih.gov/42468665/). The JAMA Network Open trial in older adults also missed its primary endpoints, hand-grip ATP production and 6-minute walk distance, with only secondary endurance measures reaching significance (https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244).

Typical dose

500 mg to 1000 mg once daily (Mitopure formulation used in nearly all published trials)

Safety

Urolithin A has been safe and well tolerated across every published trial to date, including 4-month dosing at 500-1000 mg/day in middle-aged and older adults. Preclinical toxicology found no genotoxic effects, with a no-observed-adverse-effect level of roughly 557-617 mg/kg bodyweight/day in human-equivalent terms. Long-term safety beyond several months has not been studied. Direct oral supplementation bypasses the variability of gut bacteria needed to convert dietary ellagitannins into urolithin A, so supplement-form doses reliably produce plasma levels about six times higher than pomegranate juice.

Three recent studies to know

  • Targeting aging with urolithin A in humans: A systematic review
    Ageing Research Reviews 2024

    Read study →
  • Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study
    Peer-reviewed sports science journal (PMC) 2024

    Read study →
  • Is Urolithin A (UA) a pharmacologically credible neuro-nutraceutical?
    Peer-reviewed pharmacology/nutraceutical journal (PubMed) 2026

    Read study →

Landmark studies

Found in these products (9)

All products in our catalog that contain Urolithin A, ranked by our overall score. Ranking is editorial, never paid.

Timeline Nutrition
Mitopure® Softgel
Mitochondrial
Active per serving
Urolithin A 500 mgSoftgel · 30 servings
Price per serving
$2.17$65.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$4.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.timeline.com
Mitochondrial
Active per serving
Urolithin A 500 mgCapsule · 30 servings
Price per serving
$1.87$55.97 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$3.73
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.prohealth.com
Mitochondrial
Active per serving
Urolithin A 1,000 mgCapsule · 30 servings
Price per serving
$1.97$59.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.4/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.97
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with perpetualife.us
Timeline Nutrition
Mitopure® Powder
Mitochondrial
Active per serving
Urolithin A 1,000 mgPowder stick · 28 servings
Price per serving
$4.64$130.00 · 28 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$4.64
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.timeline.com
Mitochondrial
Active per serving
Urolithin A 500 mgGummy · 30 servings
Price per serving
$4.17$125.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$8.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.timeline.com
Mitochondrial
Active per serving
Urolithin A 500 mgCapsule · 15 servings
Price per serving
$1.87$28.00 · 15 servings
Testing
None listed

Daily use may exceed one serving

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$3.73
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.swansonvitamins.com
Mitochondrial
Ingredients listed
4 ingredients listedlargest listed: Urolithin A 500 mg
Price per serving
$3.33$99.99 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$6.67
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.codeage.com
AOR (Advanced Orthomolecular Research)
Urolithin A+
Longevity stack
Ingredients listed
4 ingredients listedlargest listed: Urolithin A 1,000 mg
Price per serving
$3.21$96.44 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$3.21
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with aor.ca
Elysium Health
Creatine+
Amino acid
Ingredients listed
4 ingredients listedlargest listed: Creatine 5 g
Price per serving
$2.33$70.00 · 30 servings
Testing
None listed

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.elysiumhealth.com
Editorial guides

Buying guides and comparisons

Best Urolithin A Supplements 2026Urolithin A Evidence Review
Neighbouring molecules

Related ingredients

See all in Mitochondrial →

Molecules in the same class, plus the actives most often formulated alongside Urolithin A in our catalogue.

CoQ10Bsame categoryPQQCsame categoryAcetyl-L-CarnitineCsame categoryUbiquinolBsame categoryD-RiboseDsame categoryResveratrolCstacked together in 2 productsBetaine (TMG)Cstacked together in 1 productNMNBstacked together in 1 product
Product shelves
See all in Mitochondrial (7)See all in Longevity stack (1)See all in Amino acid (1)

See Urolithin A in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.

View Urolithin A on the Longevity Map →

Frequently asked questions

What is Urolithin A?

A molecule your gut bacteria make from pomegranate and berries, if you have the right bacteria. Only about 40% of people do. Urolithin A tells old, damaged mitochondria (the power plants inside cells) to recycle themselves, so cells work better.

What dose of Urolithin A should I take?

The trial dose in published human studies is 1000 mg per day, with a range of 500 to 1000 mg per day. Always consult a qualified clinician before starting any supplement.

Is Urolithin A safe?

No formal UL. FDA granted a GRAS no-objection letter in 2018; well tolerated in trials at doses up to 1,000 mg/day for 4 months.

What is the best Urolithin A supplement?

We track 9 products containing Urolithin A. The top-ranked product scores 8.6 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.

What is the evidence grade for Urolithin A?

Urolithin A has evidence grade A, meaning it is well-supported by replicated human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.

Independently checked

Data verification

Evidence grade
A
Replicated human RCTs with hard endpoints
Research dose
1000 mg
Products tracked
9
Updated continuously
Safety signal
No formal UL. FDA granted a GRAS no-objection letter in 2...

Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.