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AOR (Advanced Orthomolecular Research)

Urolithin A+

Longevity stack · Capsule · 30 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Ingredients listed
4 ingredients listed largest listed: Urolithin A 1,000 mg
Form
Capsule
List price (catalog, USD)
$96.44
Price per serving
$3.21List price divided by servings per container. A per-day cost only if the label serving is once daily.

Reading notes

  • Multi-ingredient product. Amounts are per ingredient per serving; the product is assessed as one bundle, not as a recommendation for each ingredient.
Full label record: servings, testing, ingredients
Servings per container
30
Serving size (label)
1.5 g
Catalog monthly estimate
$96.44
Testing disclosure
Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Urolithin A1,000 mg
Resveratrol100 mg
NMN100 mg
Spermidine5 mg

What to check on the label

  • Whether every ingredient has its own milligram line, or several are grouped in a 'blend' with one total.
  • How many capsules or scoops make a serving, and how many servings the container holds.
  • Whether the ingredients you care about appear at amounts you would accept on their own. The list below shows each figure.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

5.8/10
Overall score
#9 / 16 in Longevity stack

Tested by independent lab.

Read the evidence (3 studies)
Add to compareVisit brand site →
Watch outEU restricted2 ingredients restricted in the EU
  • NMN — Unauthorised Novel Food; EFSA positive safety opinion adopted 4 March 2026 at up to 300 mg/day (β-NMN, EffePharm dossier). Commission listing pending.
  • Spermidine — Novel Food status for concentrates >7 mg; wheat-germ traditional food
You can legally buy these outside the EU. Sale as a food supplement inside the EU requires a Novel Food authorisation these ingredients do not have.
Tier 3
Ingredient RCT (matching dose)
The ingredient was tested in an RCT at the same dose this product sells.
See the 3 supporting studies
  • Andreux et al. 2019 (Nature Metabolism) (Urolithin A)First-in-human study confirmed mitophagy induction and safety at 500 and 1000 mg. Studied at 1000 mg. This product: 1000 mg.
  • Singh et al. 2022 (Cell Reports Medicine) (Urolithin A)4 months at 1000 mg/day in adults 40 to 65: primary endpoint (peak power output) not significantly improved; ~12% leg strength gain was a secondary outcome. Studied at 1000 mg. This product: 1000 mg.
  • Jiang et al. 2026 (npj Aging) (Spermidine)Comprehensive review identifying eIF5A-TFEB axis as central autophagy mechanism. SmartAge Phase IIb showed no memory improvement at 12 months. 3.3 mg/day rice germ extract improved cardiometabolic biomarkers. 40 mg/day high-purity spermidine safe for 28 days in older men. Studied at 40 mg. This product: 5 mg.
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 7.0 of 10. Primary ingredient is Urolithin A (evidence grade A). It delivers 1000 mg, inside the studied range of 500–1000 mg. Read the rule → 7.0
Transparency (20%) Why 6.5 of 10. Earned points for independent third-party testing and all doses disclosed. Lost points for no public certificate of analysis. Read the rule → 6.5
Value (10%) Why 5.5 of 10. One day at the trial dose costs about $3.21. That is one of the pricier options in the catalog (240 of 313 by cost per effective day). Read the rule → 5.5
Formulation (10%) Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule → 5.0 Default. No absorption data on file.
Safety (5%) Why 7.0 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 7.0
Community sentiment (5%) Why 8.3 of 10. No external reviews found, so community sentiment defaults to neutral. Community never counts as clinical evidence. Read the rule → 8.3
Composite How this 5.8 is built. 0.50 × 7.0 + 0.20 × 6.5 + 0.10 × 5.5 + 0.10 × 5.0 + 0.05 × 7.0 + 0.05 × 8.3 = 5.8 out of 10. Safety caps applied after. 5.8
5.8 composite
Dose vs. studies50%7.0
Transparency20%6.5
Value10%5.5
Formulation10%5.0
Safety5%7.0
Community5%8.3

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

5.8 / 10
Best for
Full trial dose
Avoid if
No public lab certificate, Premium pricing
Full-dose status
Meets trial dose
Price/month
$96
COA status
Not public
Biggest caveat
Resveratrol (100mg is 20% of the 500mg trial dose) is significantly under-dosed.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $96.44
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context
In plain language

Why this scored this way

This AOR (Advanced Orthomolecular Research) Urolithin A+ scores 6.6, making it a mid-tier product with both strengths and weaknesses. It delivers 1000mg of Urolithin A, inside the studied range of 500–1000mg with grade A evidence (strong human trial data). At $3.21/day it's among the more expensive options in Longevity stack.

What drives the score up

  • Dose-evidence score of 7.0 shows decent alignment with trial doses.
  • Community score of 8.3 with positive consumer feedback.
  • Urolithin A is dosed at the full research level with grade A evidence (strong human trial data).

What drags it down

  • Resveratrol (100mg is 20% of the 500mg trial dose) is significantly under-dosed.
  • NMN (100mg is 20% of the 500mg trial dose) is significantly under-dosed.
  • Spermidine (5mg is 417% of the 1.2mg trial dose) is well above the trial dose. More is not always better.
  • No public lab certificate available for independent verification.
  • Quality transparency of 6.5 is below the site average.

Why you'd choose it

  • You want Urolithin A from a AOR (Advanced Orthomolecular Research) product.
  • You want a tested by independent lab product.
  • You want doses that align with published research.

Why you might skip it

  • You want a product with a publicly available CoA.
  • You need a full trial dose of resveratrol (this product under-doses it).
  • You want a standard dose of spermidine (this product is well above it).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Urolithin A

A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.

2 landmark RCTs · US: FDA GRAS · EU: Authorised Novel Food (EU 2021/85)
Resveratrol

The famous red-wine molecule; longevity claims have outrun the human evidence.

3 landmark RCTs · US: Dietary supplement · EU: Authorised Novel Food (2016/1866)
NMN

A NAD+ building block that has become the most-hyped longevity molecule.

5 landmark RCTs · US: FDA reversed exclusion 29 September 2025; NDIN 1247 and NDIN 1259 reinstated 2 December 2025; NDIN 1444 (β-NMN, Effepharm) response 28 January 2026. NMN is a dietary ingredient again; each marketer still needs NDIN coverage. · EU: Unauthorised Novel Food; EFSA positive safety opinion adopted 4 March 2026 at up to 300 mg/day (β-NMN, EffePharm dossier). Commission listing pending.
Spermidine

The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.

2 landmark RCTs · US: Dietary supplement · EU: Novel Food status for concentrates >7 mg; wheat-germ traditional food

Full ingredient breakdown

Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.

IngredientDose / servingResearch dose% of researchEvidence grade
Urolithin A1000 mg1000 mg100%A
Resveratrol100 mg500 mg20%C
NMN100 mg500 mg20%B
Spermidine5 mg1.2 mg417%C

Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$3.21/day at trial dose
What one effective daily dose actually costs
Transparency
6.5/10 · No public lab certificate
Independent batch testing confirmed
Consumer signals
584 reviews across platforms · 4.3/5 · medium confidence
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

!
Review advised
resveratrol: CYP3A4 interactions
Safety flag
resveratrol: CYP3A4 interactions
Dose or interaction risk detected. See ingredient page for details.
No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
Buyer complaints
Trustpilot: Occasional shipping delays; iHerb: Hard to notice effects
Recurring themes from consumer review platforms.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Urolithin A1000 mgEvidence A

A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.

Read about Urolithin A →
Resveratrol100 mgEvidence C

The famous red-wine molecule; longevity claims have outrun the human evidence.

Read about Resveratrol →
NMN100 mgEvidence B

A NAD+ building block that has become the most-hyped longevity molecule.

Read about NMN →
Spermidine5 mgEvidence C

The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.

Read about Spermidine →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$96
per bottle · 30 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$3.21
what one effective daily dose costs
$ / g active
$2.67
per gram of active substance
Independently checked

Data verification

COA status
Not public
Evidence grade
ACBC
Per-ingredient breakdown
AUrolithin A
CResveratrol
BNMN
CSpermidine

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Urolithin A
A mitophagy-activating metabolite with early human data; both flagship RCTs missed their primary endpoints.
Andreux et al. 2019 (Nature Metabolism)Singh et al. 2022 (Cell Reports Medicine)
1000 mg 100% of trial dose
1000 mg
Resveratrol
The famous red-wine molecule; longevity claims have outrun the human evidence.
Timmers et al. 2011 (Cell Metabolism)RESHAW 2020Lozupone 2026 (Expert Opin Investig Drugs)
100 mg 20% of trial dose
500 mg
NMN
A NAD+ building block that has become the most-hyped longevity molecule.
Yi et al. 2023 (GeroScience)Okabe et al. 2022 (Frontiers in Nutrition)Uthever RCT 2022
100 mg 20% of trial dose
500 mg
Spermidine
The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.
SmartAge (Schwarz et al. 2022, JAMA Network Open)Jiang et al. 2026 (npj Aging)
5 mg 417% of trial dose
1.2 mg
4.2 /5
High confidence
584 reviews across 4 platforms (4 sources)
Source diversity: 92%
AmazonRedditTrustpilotiHerb
PraiseFast shippingProduct quality
ComplaintsOccasional shipping delaysHard to notice effects
Last checked: 2026-08-20

Consumer signals

4.3 out of 5 across 584 verified reviews on 4 platforms.

Medium confidence

Auto-gathered from public review platforms via pplx_sdk fetch.

Trustpilot

584 reviews · 4.3/5 · positive sentiment

PraiseFast shippingProduct qualityCustomer service
ComplaintsOccasional shipping delays
Themes

AOR's Trustpilot reviews (company-wide) are strongly positive, citing quality and service.

Compiled from Trustpilot listing located during research; verified at build time.

iHerb

mixed sentiment

PraiseGood value vs name brands
ComplaintsHard to notice effectsExpensive for 30-day supply
Themes

iHerb reviewers on urolithin A products are split between noticeable benefits and no perceived effect.

Compiled from iHerb listing located during research; verified at build time.

Reddit

4 threads discussed · mixed sentiment

PraiseTrusted Canadian brand
ComplaintsLimited personal experience reports shared
Themes

Reddit users in r/urolithin_a and r/Supplements discuss AOR as a credible Canadian option but report limited firsthand feedback.

Compiled from Reddit listing located during research; verified at build time.

Amazon

5.0/5 · positive sentiment

PraiseHigh qualityAffordable pricing
Themes

The available Amazon customer review praises quality and price relative to competing urolithin A brands.

Compiled from Amazon listing located during research; verified at build time.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Urolithin AAndreux et al. 2019 (Nature Metabolism)
Urolithin ASingh et al. 2022 (Cell Reports Medicine)
ResveratrolTimmers et al. 2011 (Cell Metabolism)
ResveratrolRESHAW 2020
ResveratrolLozupone 2026 (Expert Opin Investig Drugs)
NMNYi et al. 2023 (GeroScience)
NMNOkabe et al. 2022 (Frontiers in Nutrition)
NMNUthever RCT 2022
NMNNMN meta-analysis 2024 (12 RCTs)
NMNZhang et al. 2026 meta-analysis (Nutrients)
SpermidineSmartAge (Schwarz et al. 2022, JAMA Network Open)
SpermidineJiang et al. 2026 (npj Aging)
Important to know
Urolithin ACheap 'urolithin A precursor' products (pomegranate extract) don't work if you lack the right gut bacteria. Only direct Urolithin A supplements are reliable.
Resveratrol"Resveratrol" products that don't specify trans-isomer content are unmeasurable in practice. Cis-resveratrol is biologically inactive.
NMNAbsorption varies wildly by form. Sublingual and liposomal claim better uptake but human head-to-head data is limited.
SpermidineProduct labels often say 'wheat germ extract 800 mg', that could be 0.8 mg or 8 mg of actual spermidine. Insist on labeled spermidine content.

Editorial notes

Canadian brand AOR (Advanced Orthomolecular Research) combines 1000mg urolithin A with resveratrol, NMN and spermidine in a single mitophagy/NAD+/autophagy stack; dosed as 1 capsule three times daily, 30-day supply.

Go deeper

Where this sits

Actives inside
Urolithin AResveratrolNMNSpermidine
Category
See all in Longevity stack →
Ranking
See top 10 Urolithin A supplements →
Brand
AOR (Advanced Orthomolecular Research) profile →
Add to compare Visit brand site →
Brand owners

Spot an error?

If you are the manufacturer or brand owner of Urolithin A+ and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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