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Layer 1 · Decision
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DoNotAge

DoNotAge® routine (15-in-1 Daily Sachet)

Multi/greens · Powder · 28 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Ingredients listed
5 ingredients listed largest listed: SIRT6 Activator 1,600 mg
Form
Powder
List price (catalog, USD)
$203.00
Price per serving
$7.25List price divided by servings per container. A per-day cost only if the label serving is once daily.

Reading notes

  • Multi-ingredient product. Amounts are per ingredient per serving; the product is assessed as one bundle, not as a recommendation for each ingredient.
Full label record: servings, testing, ingredients
Servings per container
28
Catalog monthly estimate
$217.50
Testing disclosure
Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
NMN1,000 mg
Betaine (TMG)1,000 mg
CoQ10200 mg
SIRT6 Activator1,600 mg
Spermidine8 mg

What to check on the label

  • Whether every ingredient has its own milligram line, or several are grouped in a 'blend' with one total.
  • How many capsules or scoops make a serving, and how many servings the container holds.
  • Whether the ingredients you care about appear at amounts you would accept on their own. The list below shows each figure.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

5.9/10
Overall score
#7 / 9 in Multi/greens

Tested by independent lab.

Read the evidence (3 studies)
Add to compareVisit brand site →
Watch outEU restricted3 ingredients restricted in the EU
  • NMN — Unauthorised Novel Food; EFSA positive safety opinion adopted 4 March 2026 at up to 300 mg/day (β-NMN, EffePharm dossier). Commission listing pending.
  • CoQ10 — Food supplement, no Novel Food status needed
  • Spermidine — Novel Food status for concentrates >7 mg; wheat-germ traditional food
You can legally buy these outside the EU. Sale as a food supplement inside the EU requires a Novel Food authorisation these ingredients do not have.
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 3 supporting studies
  • Q-SYMBIO 2014 (Mortensen et al., JACC) (CoQ10)300 mg/day in chronic HF cut major cardiovascular events 43% over 2 years. Studied at 300 mg. This product: 200 mg.
  • Yi et al. 2023 (GeroScience) (NMN)In an 80-person, 60-day dose-dependent RCT, oral NMN (up to 900 mg/day) significantly raised blood NAD+ levels, was safe and well-tolerated, and improved six-minute walking distance versus placebo. Studied at 900 mg. This product: 1000 mg.
  • Uthever RCT 2022 (NMN)In 66 adults aged 40-65 over 60 days, NMN (300 mg/day) increased serum NAD+/NADH by 38% versus baseline and improved SF-36 quality-of-life scores compared to placebo. Studied at 300 mg. This product: 1000 mg.
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 6.5 of 10. Primary ingredient is NMN (evidence grade B). It delivers 1000 mg, above the studied range of 250–900 mg. Above the range docks the score because nobody has tested that much. Read the rule → 6.5
Transparency (20%) Why 8.0 of 10. Earned points for independent third-party testing and all doses disclosed. Lost points for no public certificate of analysis. Read the rule → 8.0
Value (10%) Why 5.0 of 10. One day at the trial dose costs about $3.62. That is one of the pricier options in the catalog (259 of 313 by cost per effective day). Read the rule → 5.0
Formulation (10%) Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule → 5.0 Default. No absorption data on file.
Safety (5%) Why 7.0 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 7.0
Community sentiment (5%) Why 8.7 of 10. Sentiment across 12 external review source(s) is mostly positive. Community is a signal about daily use, not proof of effect. Read the rule → 8.7
Composite How this 5.9 is built. 0.50 × 6.5 + 0.20 × 8.0 + 0.10 × 5.0 + 0.10 × 5.0 + 0.05 × 7.0 + 0.05 × 8.7 = 5.9 out of 10. Safety caps applied after. 5.9
5.9 composite
Dose vs. studies50%6.5
Transparency20%8.0
Value10%5.0
Formulation10%5.0
Safety5%7.0
Community5%8.7

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

5.9 / 10
Best for
Full trial dose
Avoid if
No public lab certificate, Premium pricing
Full-dose status
Meets trial dose
Price/month
$218
COA status
Not public
Biggest caveat
SIRT6 Activator (1,600 mg) has evidence grade E: no independent human RCT exists. All supporting data comes from DoNotAge-funded animal research (Gorbunova lab).
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $203.00
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context

Our summary

DoNotAge routine is a 15-in-1 daily sachet that dissolves in water and delivers approximately 9.6 g of active ingredients per serving at $7.25/day. It combines NAD+ precursors (NMN 1,000 mg, TMG 1,000 mg), sirtuin activators (SIRT6 Activator 1,600 mg, resveratrol 500 mg), mitochondrial support (CoQ10 200 mg), senolytic compounds (quercetin 400 mg, spermidine 8 mg), metabolic support (Ca-AKG 800 mg, glycine 2,000 mg), and proprietary additions (Nitralis, SulforaBoost, hyaluronic acid, D3, K2). The company conducted a 60-day double-blind placebo-controlled trial on the finished product (n=28), reporting improved well-being and reduced fatigue, but the trial used subjective endpoints, was company-funded and company-authored, and has no peer-reviewed publication. Independent lab verification exists only for the standalone NMN ingredient (98% purity, no heavy metals), not for the sachet itself. The product is the most expensive all-in-one longevity stack on the market ($203/month vs NOVOS Core at $109, Blueprint at $49, AgeMate at $69-79), but uniquely discloses individual per-ingredient doses rather than using blends without listed amounts. Key concerns include the contested Nitralis trial, affiliate-heavy review ecosystem, and unverified NAD+ marketing claims.
In plain language

Why this scored this way

The most ambitious all-in-one longevity stack we've scored: 15 ingredients at $7.25/day with a company-run 60-day RCT on the finished product. The score lands at 6.8 because the formulation drags it down hard: several ingredients (SIRT6 Activator, Nitralis) sit at evidence grade E with no independent human data, and the company's own trial used subjective well-being endpoints rather than aging biomarkers. Value and community scores are high, but transparency is capped at 8.0 because there is no public lab certificate for the sachet itself.

What drives the score up

  • 15 ingredients in one daily sachet is the broadest longevity formulation on the market, covering NAD+ precursors, sirtuin activators, senolytics, and mitochondrial support in a single serving.
  • NMN is dosed at 1,000 mg, double the 500 mg trial dose and matching the top of the human trial range.
  • Spermidine at 8 mg exceeds most commercial doses and is well above the 1.2 mg used in human autophagy studies.
  • The company ran a double-blind placebo-controlled trial on the finished sachet (n=28), not just individual ingredients, something almost no competitor has done.
  • Trustpilot ratings of 4.2-4.5/5 across 8 regional domains with 267-548 reviews each give a strong community score.
  • At $3.63 per day at studied dose, the value score is high because the sachet delivers multiple research-level doses in one product.

What drags it down

  • SIRT6 Activator (1,600 mg) has evidence grade E: no independent human RCT exists. All supporting data comes from DoNotAge-funded animal research (Gorbunova lab).
  • Nitralis is backed by a company-funded, company-authored pilot trial that measured salivary nitrite, not blood nitric oxide or any clinical endpoint. Dr. Brad Stanfield estimates it delivers only ~60 mg actual nitrate, about 15% of RCT doses showing vascular benefit.
  • The 60-day sachet trial used subjective endpoints (WHO-5 well-being, FACIT-Fatigue) rather than objective aging biomarkers. All study authors are DoNotAge employees. No peer-reviewed publication was found.
  • No public lab certificate for the finished sachet. Independent lab verification exists only for standalone NMN capsules (98% purity), not the 15-in-1 product.
  • At $203/month it is the most expensive all-in-one longevity stack on the market: NOVOS Core costs $109, Blueprint $49, AgeMate $69-79.
  • The widely repeated '76% NAD+ increase' marketing claim could not be verified against the company's own trial data.
  • Nearly all sachet-specific YouTube reviews are affiliate-monetized, which may bias the community sentiment.

Why you'd choose it

  • You want one product that covers the broadest range of longevity pathways and cannot be bothered managing 15 separate bottles.
  • You value convenience over cost and are comfortable paying $203/month for a daily sachet.
  • You want a product where the finished formula itself was tested in a clinical trial, even if the trial was company-funded.
  • You specifically want SIRT6 Activator or Nitralis, which are proprietary to DoNotAge.

Why you might skip it

  • You care about evidence quality: several ingredients have no independent human data and the company trial used subjective endpoints.
  • You want a public lab certificate or third-party certification (NSF, USP) for the finished product.
  • You want the best value per dollar: NOVOS Core at $109/month or Blueprint at $49/month cover similar ground at a fraction of the cost.
  • You are uncomfortable with a product whose marketing claims (76% NAD+ increase, 226% nitric oxide) could not be verified against primary trial data.
  • You want to control individual ingredient doses: a sachet locks you into the manufacturer's ratio whether or not it matches your needs.
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

NMN

A NAD+ building block that has become the most-hyped longevity molecule.

5 landmark RCTs · US: FDA reversed exclusion 29 September 2025; NDIN 1247 and NDIN 1259 reinstated 2 December 2025; NDIN 1444 (β-NMN, Effepharm) response 28 January 2026. NMN is a dietary ingredient again; each marketer still needs NDIN coverage. · EU: Unauthorised Novel Food; EFSA positive safety opinion adopted 4 March 2026 at up to 300 mg/day (β-NMN, EffePharm dossier). Commission listing pending.
Betaine (TMG)

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

No landmark RCTs listed · US: Dietary supplement, GRAS · EU: Food supplement, permitted
CoQ10

A well-established mitochondrial cofactor, especially useful on statins.

1 landmark RCT · US: Dietary supplement · EU: Food supplement, no Novel Food status needed
SIRT6 Activator

DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.

1 landmark RCT · US: Dietary supplement · EU: Food supplement (seaweed-derived)
Spermidine

The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.

2 landmark RCTs · US: Dietary supplement · EU: Novel Food status for concentrates >7 mg; wheat-germ traditional food

Full ingredient breakdown

Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.

IngredientDose / servingResearch dose% of researchEvidence grade
NMN1000 mg500 mg200%B
Betaine (TMG)1000 mg3000 mg33%C
CoQ10200 mg200 mg100%B
SIRT6 Activator1600 mg4000 mg40%E
Spermidine8 mg1.2 mg667%C

Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
400% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$3.62/day at trial dose
What one effective daily dose actually costs
Transparency
8.0/10 · No public lab certificate
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

!
Review advised
coq10: warfarin/anticoagulant interaction
Safety flag
coq10: warfarin/anticoagulant interaction
Dose or interaction risk detected. See ingredient page for details.
No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
Plain English

What’s inside

The main ingredients of this product, in plain language.

NMN1000 mgEvidence B

A NAD+ building block that has become the most-hyped longevity molecule.

Read about NMN →
Betaine (TMG)1000 mgEvidence C

A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.

Read about Betaine (TMG) →
CoQ10200 mgEvidence B

A well-established mitochondrial cofactor, especially useful on statins.

Read about CoQ10 →
SIRT6 Activator1600 mgEvidence E

DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.

Read about SIRT6 Activator →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$203
per bottle · 28 servings
Dose vs. research
Above trial dose 400%
of published effective dose
$ / day at studied dose
$3.62
what one effective daily dose costs
$ / g active
$1.90
per gram of active substance
Independently checked

Data verification

COA status
Not public
Evidence grade
BCBEC
Per-ingredient breakdown
BNMN
CBetaine (TMG)
BCoQ10
ESIRT6 Activator
CSpermidine

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
NMN
A NAD+ building block that has become the most-hyped longevity molecule.
Yi et al. 2023 (GeroScience)Okabe et al. 2022 (Frontiers in Nutrition)Uthever RCT 2022
1000 mg 200% of trial dose
500 mg
Betaine (TMG)
A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.
1000 mg 33% of trial dose
3000 mg
CoQ10
A well-established mitochondrial cofactor, especially useful on statins.
Q-SYMBIO 2014 (Mortensen et al., JACC)
200 mg 100% of trial dose
200 mg
SIRT6 Activator
DoNotAge's proprietary angle; genuinely interesting biology, extremely early evidence.
Rahman et al. 2014
1600 mg 40% of trial dose
4000 mg
Spermidine
The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.
SmartAge (Schwarz et al. 2022, JAMA Network Open)Jiang et al. 2026 (npj Aging)
8 mg 667% of trial dose
1.2 mg
4.3 /5
Medium confidence Strong value signal
3,152 reviews across 2 platforms (8 sources)
Source diversity: 70%
RedditTrustpilot
Last checked: 2026-08-20

Consumer signals

Consumer signals gathered from 8 platforms.

Low confidence, small sample

Consumer sentiment compiled from Trustpilot (brand-level) and Reddit discussions. Small sample size, treat as directional only.

Trustpilot

556 reviews · 4.1/5

Reddit

Reddit

Same brand profile on Trustpilot country sites: UK 4.4 · Germany 4.4 · Switzerland 4.4 · Italy 4.3 · Spain 4.5.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Independent German lab test — DoNotAge NMN capsules (Reddit r/Supplements)
No affiliate relationship Not a paid placement

A user paid €315 for a certified German laboratory (Limbach GmbH, EN ISO/IEC 17025:2018 accredited) to assay DoNotAge's NMN capsules using H-NMR and ICP-MS. Result: ~98% (±2%) purity, trace niacinamide (~0.09%), heavy metals below detectable limits, ~11% overfill vs label claim.

Finding: ~98% purity, no heavy metals, 11% overfill
How we use it: Independent physical-product verification of DoNotAge NMN. Applies to standalone NMN, not the finished sachet.
Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Trustpilot — DoNotAge.org aggregate reviews (8 regional domains)
No affiliate relationship Not a paid placement

Across 8 Trustpilot regional domains, DoNotAge holds 4.2-4.5/5 ratings with 267-548 reviews per domain. Praise centers on product quality, energy, mental clarity, sleep, and customer service. Complaints focus on delivery times, international shipping, subscription/pricing discrepancies, and one adverse-event report. No Trustpilot review specifically named the routine sachet product.

Finding: 4.2-4.5/5 across 8 domains, 267-548 reviews each
How we use it: Brand-level community sentiment. Applies to DoNotAge broadly, not the sachet specifically.
Dr. Brad Stanfield — physician critique of Nitralis trial (YouTube + blog)
No affiliate relationship Not a paid placement

Physician YouTuber Dr. Brad Stanfield publicly criticized the Nitralis trial: (1) measured salivary nitrite, not blood NO or clinical endpoints; (2) no independent ethics board approval; (3) delivers ~60 mg actual nitrate, ~15% of RCT doses showing vascular benefit; (4) calls the '226% increase' claim 'ungrounded' and the study 'basically worthless.'

Finding: ~60 mg actual nitrate vs ~400 mg in vascular RCTs
How we use it: Independent clinical critique of a key sachet ingredient's evidence base.
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Reddit r/Supplements, r/NMN, r/Nootropics — brand trust discussion
No affiliate relationship Not a paid placement

Mixed brand-trust discussion across Reddit. Some threads from 2022 allege aggressive affiliate marketing and deleted critical Facebook posts. A DoNotAge Partner Manager acknowledged a problematic ad from a former marketing agency. Recent threads (2024-2026) increasingly recommend DoNotAge alongside Renue By Science as reputable NMN brands. No dedicated Reddit thread specifically reviewing the routine sachet was found.

How we use it: Community sentiment context for the brand, not the sachet specifically.
YouTube — sachet-specific review videos (9+ videos found)
Has affiliate relationship Not a paid placement

9+ YouTube videos specifically review the routine sachet. Nearly all are affiliate-monetized (referral/discount codes in descriptions). Coverage ranges from unboxing to one-month follow-up. Independent, non-monetized critical reviews of the sachet specifically were not found.

How we use it: Video review landscape is overwhelmingly affiliate-linked. Sentiment should be treated with caution.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Clinical study
positive

60-day company-funded trial on 15-ingredient sachet showed 76-79% NAD+ increase and 19% reduction in perceived fatigue. Tested as finished product, not individual ingredients.

Unverified · we received no payment for this listing
Independent comparison
positive

Ranked #1 longevity supplement stack by independent comparison site for formulation depth and clinical evidence. Noted as highest price at ~$203/month.

Unverified · we received no payment for this listing
Independent reviewer
positive

Longevity content creator reviewed entire product line, gave 4.5/5. Described brand as having good reputation for quality and trustworthiness, citing tested by independent lab ingredients with low heavy metal content.

Unverified · we received no payment for this listing
Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 4Ingredient RCT (different dose)
3 studies mapped
Tier 4Ingredient RCT (different dose)
DoNotAge routine sachet — 60-day well-being and fatigue trial
DoNotAge.org staff (company-funded) · 2026 · Self-published on routine.donotage.org/science · n=28 · 1 sachet/day (full 15-ingredient formula) · 60 days
on this exact productnot peer-reviewed
WHO-5 well-being scores more than doubled; FACIT-Fatigue dropped 19%; 93% felt better or much better. Both primary endpoints significant at p < 0.0001.
The only known RCT testing the finished sachet product itself (not just individual ingredients). Strengths: double-blind, placebo-controlled, multi-endpoint. Weaknesses: small n, subjective endpoints only, no peer-reviewed publication, company-funded and company-authored.
Conflicts: All study authors are DoNotAge employees. Trial was funded by DoNotAge. No independent ethics board approval documented.
Source →
Tier 4Ingredient RCT (different dose)
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Yoshino M, Yoshino J, Kayser BD, et al. · 2021 · Science · n=25 · 250 mg/day · 10 weeks
ingredient-levelpeer-reviewed
Modestly improved insulin sensitivity and muscle insulin signalling. Did not detect a measurable rise in blood NAD+.
The sachet delivers 1,000 mg NMN, 4x the dose in this landmark trial.
Conflicts: None identified; academic study (Washington University) with NIH funding.
Source →
Tier 4Ingredient RCT (different dose)
Nitralis nitric oxide pilot trial
DoNotAge.org staff (company-funded) · 2024 · Biomedical Journal of Scientific & Technical Research (self-published via biomedres.us) · n=85 · Nitralis blend without listed amounts · 30 days
ingredient-levelnot peer-reviewed
Claims +226% increase in salivary nitrite. No blood NO, blood pressure, or vascular endpoint measured.
Contested pilot study. The '226% increase' figure is widely repeated in marketing but refers to salivary nitrite, not a validated clinical outcome.
Conflicts: All authors are DoNotAge employees. Funded by DoNotAge. No independent ethics board approval. Criticized by Dr. Brad Stanfield for measuring salivary nitrite (not blood NO or clinical endpoints) and for delivering only ~60 mg actual nitrate (~15% of RCT doses showing vascular benefit).
Source →
Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

NMNYi et al. 2023 (GeroScience)
NMNOkabe et al. 2022 (Frontiers in Nutrition)
NMNUthever RCT 2022
NMNNMN meta-analysis 2024 (12 RCTs)
NMNZhang et al. 2026 meta-analysis (Nutrients)
CoQ10Q-SYMBIO 2014 (Mortensen et al., JACC)
SIRT6 ActivatorRahman et al. 2014
SpermidineSmartAge (Schwarz et al. 2022, JAMA Network Open)
SpermidineJiang et al. 2026 (npj Aging)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support
“One supplement. Every hallmark of ageing. 15 powerful longevity ingredients in one easy-to-take sachet.”
The sachet does contain 15 ingredients, several of which have human trial data supporting specific health outcomes. However, 'every hallmark of ageing' is a marketing framing, not a tested claim — the company's own trial measured subjective well-being and fatigue, not aging hallmarks or biomarkers.
Vendor source
Unverified
“76% increase in NAD+ over 60 days”
The '76% NAD+ increase' figure is widely repeated in affiliate marketing content and YouTube videos but does not appear on DoNotAge's own science page, which instead reports WHO-5 well-being and FACIT-Fatigue outcomes. This claim could not be matched to any primary trial data and should be treated as a marketing/affiliate talking point pending direct confirmation.
Affiliate and YouTube sources repeating the figure; not found verbatim on the official science page.
Misleading
“+226% increase in nitric oxide (Nitralis ingredient)”
The study measured salivary nitrite, not blood nitric oxide or any vascular/clinical endpoint. All study authors are DoNotAge employees and the trial was company-funded with no independent ethics board approval. Dr. Brad Stanfield estimates Nitralis delivers only ~60 mg of actual nitrate, about 15% of doses used in RCTs that showed genuine vascular benefit.
Vendor source
Unverifiable
“$203 vs $683 individual ingredient cost — 70% discount”
The 'compare at' reference price fluctuated between $683 and $762 across different page states observed during research. The comparison price is not independently auditable and appears to be a marketing construct rather than a verified market basket.
Vendor source
Claim Only
“100% money-back guarantee”
Advertised prominently. Specific terms, time limits, and conditions were not independently verified.
Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

US
Legal as supplement
NMN was reinstated as lawful for supplement sale by the FDA on September 29, 2025, following a Natural Products Association citizen petition. The sachet contains multiple ingredients generally recognized as dietary supplement components.
Last verified 2026-08-07
EU
Novel Food, not cleared
NMN has not received EU Novel Food authorisation. The sachet's NMN content may face the same regulatory uncertainty as standalone NMN products in the EU market.
Last verified 2026-08-07
UK
Legal as supplement
DoNotAge is UK-based and operates under UK supplement regulations post-Brexit.
Last verified 2026-08-07

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • Exact per-ingredient mg doses were not confirmed from an official DoNotAge supplement-facts label. The routine.donotage.org page renders its label via JavaScript/image, not extractable plaintext. All specific mg figures come from third-party review sites that claim to cite the official label.
  • Vitamin D3 and magnesium exact doses within the sachet were not confirmed by any source in this research pass.
  • No independent (non-DoNotAge-funded) lab testing or CoA of the finished sachet product was found. All third-party lab verification pertains to the standalone Pure NMN product, not the 15-in-1 sachet.
  • The '76% NAD+ increase' marketing claim could not be verified against the primary trial data. The company's own science page reports well-being and fatigue outcomes, not NAD+ levels.
  • The '$683 individual ingredient comparison price' is not independently auditable and fluctuated between $683 and $762 across page states.
  • No peer-reviewed publication of the sachet's 60-day clinical trial was found. The company offers 'the full paper' as a downloadable resource but the direct paper URL was not surfaced.
  • Most available sachet-specific YouTube and blog reviews are affiliate-monetized, which may bias sentiment. Independent non-affiliate critical reviews are more common for individual DoNotAge ingredients than for the sachet as a whole.
Important to know
NMNAbsorption varies wildly by form. Sublingual and liposomal claim better uptake but human head-to-head data is limited.
Betaine (TMG)Doses under roughly 500 mg/day (as seen in most NAD+ combination products) are well below the gram-level doses used in the supporting human trials.
CoQ10Cheap CoQ10 powder in capsules has minimal absorption. Look for softgels with oil carrier or ubiquinol form.
SIRT6 ActivatorFucoidan is inexpensive as a seaweed extract. High-priced 'SIRT6 activator' branding doesn't mean higher potency, check fucoidan mg/capsule.
SpermidineProduct labels often say 'wheat germ extract 800 mg', that could be 0.8 mg or 8 mg of actual spermidine. Insist on labeled spermidine content.

Editorial notes

DoNotAge's flagship 2026 all-in-one sachet combining 15 ingredients (NMN 1,000 mg, TMG 1,000 mg, Ca-AKG 800 mg, CoQ10 200 mg, SIRT6 Activator 1,600 mg, spermidine 8 mg, resveratrol 500 mg, quercetin 400 mg, Nitralis, glycine 2,000 mg, SulforaBoost, hyaluronic acid 200 mg, D3, K2 120 mcg, magnesium) at $7.25/day. Company ran a 60-day double-blind placebo-controlled trial on the finished product (n=28) showing improved well-being and reduced fatigue, but with subjective endpoints, no peer-reviewed publication, and all authors are company employees. Independent lab verification exists only for standalone NMN (98% purity, no heavy metals), not the sachet itself. Most expensive all-in-one longevity stack on the market ($203/month vs NOVOS Core $109, Blueprint $49). Contested Nitralis trial and unverified '76% NAD+ increase' marketing claim. Full dossier with 15-ingredient dose analysis, clinical trial breakdown, third-party lab results, Trustpilot sentiment, competitor comparison, and data gaps available on this page.

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Where this sits

Actives inside
NMNBetaine (TMG)CoQ10SIRT6 ActivatorSpermidine
Category
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Ranking
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Brand
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