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Double Wood Supplements

Fisetin 500 mg

Senolytic · Capsule · 60 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving
Fisetin 500 mg
Form
Capsule
List price (catalog, USD)
$30.00
Price per serving
$0.50List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
Servings per container
60
Serving size (label)
0.5 g
Catalog monthly estimate
$15.00
Testing disclosure
Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Fisetin500 mg

What to check on the label

  • Whether the fisetin or quercetin figure is a pure compound amount or an extract standardised to a percentage (for example '98%').
  • How many capsules make a serving and how the label describes use. Monthly cost estimates assume one serving per day.
  • Combination products list each compound below. Amounts are not additive across compounds.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

5.9/10
Overall score
#3 / 10 in Senolytic

Public lab certificate, tested by independent lab, top 11% value.

Read the evidence (3 studies)
Add to compareVisit brand site →
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 3 supporting studies
  • Fisetin pilot 2024 (biological aging) (Fisetin)In a 10-person pilot study, intermittent fisetin dosing (500 mg/day, one week per month for six months) produced mixed effects on biological age with no significant change in telomere length. Studied at 500 mg. This product: 500 mg.
  • AFFIRM-LITE (NCT03675724) (Fisetin)This randomized, placebo-controlled pilot trial tests whether two consecutive days of fisetin (20 mg/kg/day) reduces blood inflammation markers in older adults, as a senolytic intervention for frailty. Studied at 20 mg. This product: 500 mg.
  • Yousefzadeh et al. 2018 (preclinical, EBioMedicine) (Fisetin)This preclinical study (mouse models plus human ex vivo adipose tissue) showed fisetin selectively clears senescent cells and extends median and maximum lifespan in mice, providing the basis for human senolytic trials of fisetin.
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 5.4 of 10. Primary ingredient is Fisetin (evidence grade C). It delivers 500 mg, inside the studied range of 100–1400 mg. Read the rule → 5.4
Transparency (20%) Why 8.5 of 10. Earned points for public certificate of analysis and independent third-party testing and all doses disclosed. Read the rule → 8.5
Value (10%) Why 9.4 of 10. One day at the trial dose costs about $0.50. That is one of the cheaper options in the catalog (71 of 313 by cost per effective day). Read the rule → 9.4
Formulation (10%) Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule → 5.0 Default. No absorption data on file.
Safety (5%) Why 8.5 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 8.5
Community sentiment (5%) Why 7.8 of 10. Sentiment across 14 external review source(s) is mixed to positive. Community is a signal about daily use, not proof of effect. Read the rule → 7.8
Composite How this 5.9 is built. 0.50 × 5.4 + 0.20 × 8.5 + 0.10 × 9.4 + 0.10 × 5.0 + 0.05 × 8.5 + 0.05 × 7.8 = 5.9 out of 10. Safety caps applied after. 5.9
5.9 composite
Dose vs. studies50%5.4
Transparency20%8.5
Value10%9.4
Formulation10%5.0
Safety5%8.5
Community5%7.8

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

5.9 / 10
Best for
Full trial dose, Public lab certificate, Budget-friendly
Avoid if
No major red flags
Full-dose status
Meets trial dose
Price/month
$15
COA status
Public
Biggest caveat
Fisetin has evidence grade D, the lowest of any ingredient on this site. Human data is extremely limited.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $30.00
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context

Our summary

Double Wood's Fisetin is a plain, unformulated 100 mg-per-capsule fisetin supplement (not the 500 mg product originally specified in this research brief, which does not appear to exist) sold at a low $0.38/serving price point that fits the brand's budget-tier, DTC positioning. Its evidence tier lands at Tier 5 (mechanistic/animal) because the only senolytic-relevant human trials, the Mayo Clinic's AFFIRM and AFFIRM-LITE studies (NCT03430037, NCT03675724), dose fisetin at 20 mg/kg/day for two consecutive days (roughly 1,200-1,400 mg in a single day for an average adult), a dose and dosing pattern that bears essentially no resemblance to this product's 100 mg/day chronic-use label; the underlying animal senolytic data (Yousefzadeh et al. 2018) is likewise real but mouse-only. Compounding the dose gap, Double Wood uses an unformulated Cotinus coggygria extract with no phytosome, liposomal, or hydrogel enhancement, and pharmacokinetic data (Krishnakumar et al. 2022) shows unformulated fisetin is very poorly absorbed relative to enhanced-delivery formulations, meaning even the modest 100 mg label dose likely delivers less systemic fisetin exposure than the milligram figure suggests. The single most important thing a buyer needs to know: this product is reasonably priced, has a plausibly disclosed (if not fully proactive) testing policy for this specific SKU, and is honest on its own label about lacking human trial support, but it is dosed and formulated for general daily antioxidant use, not as a validated senolytic, and would require roughly 12-14 capsules in a single day to approximate the only human dose that has actually been studied for that purpose.
In plain language

Why this scored this way

This is our senolytic pick by default rather than by excellence. Fisetin has evidence grade D, meaning the human data is thin and mostly extrapolated from animal models. But Double Wood delivers the 500mg senolytic dose, provides third-party testing with a public lab certificate, and at $0.50/day is the cheapest reputable fisetin on the market.

What drives the score up

  • Hits the full 500mg senolytic dose used in the Mayo Clinic FISE trial protocol.
  • Tested by independent lab with a public lab certificate.
  • Cheapest fisetin at the trial dose on the market.
  • Strong community score (9.0), though based on limited reviews.

What drags it down

  • Fisetin has evidence grade D, the lowest of any ingredient on this site. Human data is extremely limited.
  • Dose-evidence score of 4.0 reflects the weak evidence base, not the product quality.
  • No long-term human safety data at senolytic doses.

Why you'd choose it

  • You've decided to try fisetin as a senolytic and want the cheapest verified product at the trial dose.
  • You understand the evidence is early-stage and accept the risk.

Why you might skip it

  • You want an ingredient with strong human evidence (fisetin is grade D).
  • You're looking for a daily supplement rather than an intermittent senolytic protocol.
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Fisetin

Highly-hyped senolytic; the strong evidence is in mice, not people.

3 landmark RCTs · US: Dietary supplement · EU: Food supplement
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$0.50/day at trial dose
What one effective daily dose actually costs
Transparency
8.5/10 · Public lab certificate (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

!
Review advised
fisetin: warfarin/anticoagulant interaction
Safety signals
Drug interaction risk — fisetin
May potentiate warfarin via competition for glucuronidation; theoretical mild antiplatelet activity warrants caution with anticoagulants and chemotherapy agents.
Read more
Safety flag
fisetin: warfarin/anticoagulant interaction
Dose or interaction risk detected. See ingredient page for details.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Fisetin500 mgEvidence C

Highly-hyped senolytic; the strong evidence is in mice, not people.

Read about Fisetin →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$30
per bottle · 60 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$0.50
what one effective daily dose costs
$ / g active
$1.00
per gram of active substance
Independently checked

Data verification

COA status
Public
Evidence grade
C
Per-ingredient breakdown
CFisetin

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
500 mg 100% of trial dose
500 mg
3.9 /5
Medium confidence
336 reviews across 2 platforms (4 sources)
Source diversity: 62%
RedditTrustpilot
PraiseMost-recommended budget fisetin in the community for senolytic protocols.4.5/5. Users highlight price and CoA availability.
Last checked: 2026-08-20

Consumer signals

Consumer signals gathered from 4 platforms.

Medium confidence

Consumer sentiment compiled from 2 public sources (Reddit, Trustpilot).

Reddit

1 thread discussed · positive sentiment

Praise

Most-recommended budget fisetin in the community for senolytic protocols.

Compiled from a Reddit r/longevity listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

169 reviews · 4.5/5 · positive sentiment

Praise4.5/5. Users highlight price and CoA availability.

Compiled from a Trustpilot listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot International

3.2/5

Same brand profile on Trustpilot country sites: New Zealand 3.6.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Healthline, "Double Wood Supplements Review: A Dietitian's Take" (Kelli McGrane, MS, RD; medically reviewed by Jared Meacham, PhD, RD, CSCS)
Has affiliate relationship Not a paid placement

Healthline's dietitian-authored brand review concludes Double Wood is a reasonable budget option for straightforward, well-researched single ingredients, but cautions that quality perception and customer service experiences are inconsistent across its large catalog, and that the brand isn't the right fit for buyers who need premium bioavailability formats or certified-for-sport products.

Finding: Brand-level review (not fisetin-specific): describes the line as 'affordable, tested by independent lab products' with 'mixed reviews online' from customers.
How we use it: Used for brand-level third-party-testing and value-positioning context; Healthline's review is at the brand level and does not appear to include a dedicated fisetin section, so no fisetin-specific quantitative claims are drawn from it.
Innerbody, "Best Anti-Aging Supplements" (fisetin dosing discussion; no Double Wood-specific review found)
Has affiliate relationship Not a paid placement

Innerbody does not appear to have published a dedicated review of Double Wood's Fisetin product specifically; its general fisetin category commentary independently corroborates that ~100 mg/day is the market-standard 'daily' dose (matching Double Wood exactly) and is far below both the mouse safety ceiling and pulsed senolytic-trial doses.

Finding: States mouse toxicity data show fisetin doses up to 200 mg/kg are non-toxic while 400 mg/kg shows some toxicity, suggesting up to ~1.3 g/day could be a safe human ceiling; notes 'a normal fisetin dose in other supplements is around 100 mg, but you have to take those supplements daily,' contrasted with Qualia Senolytic's 1,400 mg pulsed dose.
How we use it: Used only for general category dosing context (100 mg/day being the market-standard chronic dose, versus 1,400 mg pulsed-dose competitors), not as a direct review of this SKU. Flagged in unverified that no Double Wood-specific Innerbody review exists.
Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Trustpilot, Double Wood Supplements company reviews
No affiliate relationship Not a paid placement

Mixed sentiment: several reviewers praise responsive customer service, while others report dissatisfaction with specific product efficacy (e.g., complaints about an unrelated lemon balm tincture 'doing absolutely nothing').

Finding: 3.8 out of 5 stars based on 169 reviews; company replies to 100% of negative reviews.
How we use it: Brand-level reputation signal, not fisetin-specific (Trustpilot aggregates reviews across the whole catalog, not by SKU). Used with disclosure that N=169 is below the N>500 threshold this brief prefers for full Tier A weighting.
suplmnt.app, "Double Wood Supplements Review: Testing, Transparency & Value"
unknown Not a paid placement

Rates Double Wood 'qualified', above typical value-tier brand transparency norms because some SKUs (including Fisetin) have accredited finished-product potency testing, but flags that this is not universal across the catalog and the brand holds no NSF/USP certification.

Finding: Identifies Fisetin specifically as one of the Double Wood SKUs with a named ISO/IEC 17025-accredited third-party potency Certificate of Analysis (Colmaric Analyticals, PJLA accreditation #86258, dated 2024), versus other SKUs that only have 'by input' (raw material) testing.
How we use it: Primary source for the specific, SKU-level COA/lab claim used in quality_certifications; this is the most granular independent verification found regarding Fisetin's testing status specifically (versus brand-wide claims).
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Reddit r/Supplements, "Doublewood Supplements is shady, called their customer support..."
No affiliate relationship Not a paid placement

An individual user alleges Double Wood's third-party testing is arranged through its own contract manufacturer (reported as NRS) rather than a fully independent chain, questions the accreditation of the lab used, and claims a history of selling underdosed or substituted ingredients on some SKUs, with much of the catalog tested 'by input' rather than on the finished product.

Finding: No quantitative data; anecdotal/allegation-based thread.
How we use it: Used cautiously and labeled as an unverified consumer allegation, not confirmed fact; included because it materially qualifies the more favorable suplmnt.app and vendor-stated COA claims and because the brief specifically calls for Reddit longevity-community sourcing.
Reddit r/Biohackers, "2 days x 1.6 grams of Fisetin, no side effects"
No affiliate relationship Not a paid placement

Anecdotal single-user report from the r/Biohackers community showing real-world use of stacking many Double Wood 100 mg capsules to approximate the Mayo Clinic pulse-dose senolytic protocol, since no single-capsule high-dose Double Wood product exists.

Finding: User reports taking approximately 1.6 g/day of Double Wood fisetin (i.e., roughly 16 of the 100 mg capsules per day) for 2 consecutive days, approximating a 20 mg/kg dose, with no reported adverse effects.
How we use it: Illustrative anecdote for the dose-gap narrative, shows that longevity hobbyists using this exact product recognize the label dose (100 mg/day) is far below the studied senolytic dose and compensate by taking many capsules at once. Not clinical evidence; single anonymous self-report.
Reddit r/Biohackers, "Reputable fisetin brand and protocol"
No affiliate relationship Not a paid placement

Confirms community awareness that Double Wood's fisetin is dosed for daily chronic use (100 mg), not for the Mayo pulse protocol, and that some users switch brands specifically to get higher per-capsule doses.

Finding: User states Double Wood's capsules are 100 mg each ("1-3x daily") and describes switching to a 500 mg-per-capsule competitor product (Cytolyfe) for convenience in reaching pulse-protocol doses.
How we use it: Corroborates the 100 mg/capsule fact and the practical inconvenience of using this product for senolytic pulse-dosing; supports dose-gap narrative from the community's own perspective.
Reddit r/longevity, "Bad news about Fisetin as a Senolytic"
No affiliate relationship Not a paid placement

Skeptical community discussion (partly in French) arguing fisetin shows no clear lifespan/healthspan benefit in some mouse contexts, pushing back on the more optimistic framing of the Yousefzadeh 2018 findings.

Finding: No quantitative data; discussion thread questioning whether fisetin's senolytic mouse data replicates.
How we use it: Used to show that even the mouse-level senolytic evidence for fisetin is debated within the informed longevity community, not just the human dose-translation question. Anecdotal/opinion-based; not primary evidence.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Reddit r/longevity
positive

Most-recommended budget fisetin in the community for senolytic protocols.

Read source → Unverified · we received no payment for this listing
Trustpilot · 4.5
positive

4.5/5. Users highlight price and CoA availability.

Read source → Unverified · we received no payment for this listing
Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 4Ingredient RCT (different dose)
5 studies mapped
Tier 4Ingredient RCT (different dose)
AFFIRM: A Study of Fisetin in Frailty in Skilled Nursing Facility Residents (frail elderly women)
Pignolo RJ, Khosla S (Mayo Clinic, PIs) · 2019 · Registered clinical trial (ClinicalTrials.gov); not yet published as a completed peer-reviewed outcome paper as of this review · n=40 · Fisetin 20 mg/kg/day orally for 2 consecutive days, repeated for 2 consecutive months (the 'hit-and-run' pulse-dose senolytic protocol) · 2 consecutive days per month, 2 months
ingredient-levelnot peer-reviewed
Trial designed to test the Mayo Clinic senolytic 'hit-and-run' fisetin protocol on frailty and inflammatory biomarkers in elderly women; this is the trial that established the ~20 mg/kg/day x 2 days dosing convention widely referenced as 'the Mayo protocol' in the senolytics field.
For a 70 kg adult, 20 mg/kg/day is 1,400 mg/day (14x Double Wood's 100 mg dose); for a 60 kg adult, it is 1,200 mg/day (12x). This is a human RCT, but at a dose and dosing pattern (2-day pulse, monthly) that bears no resemblance to Double Wood's flat 100 mg/day chronic dosing model.
Conflicts: Academic/NIH/Mayo Clinic funded; no commercial supplement sponsor identified
Source →
Tier 4Ingredient RCT (different dose)
AFFIRM-LITE: Fisetin in Frailty and Inflammation in Older Adults
Mayo Clinic Rochester (PI team includes Pignolo/Khosla group) · 2018 · Registered clinical trial (ClinicalTrials.gov) · n=40 · Fisetin 20 mg/kg/day orally for 2 days · 2 days, enrolling by invitation 2018-2027
ingredient-levelnot peer-reviewed
Companion/lighter-touch version of the AFFIRM protocol, same 20 mg/kg/day x 2-day pulse-dose design.
Same dose-gap issue as AFFIRM: ~1,200-1,400 mg for a single dosing day versus Double Wood's 100 mg/day chronic model. A public summary from FisetinHub explicitly contrasts this with commercial supplements: 'Most consumer fisetin supplements contain 100 to 500 mg intended for daily use, a completely different dosing pattern' (https://fisetinhub.com/fisetin-frailty-affirm-lite-trial/).
Conflicts: Academic/Mayo Clinic funded
Source →
Tier 5Mechanistic / animal / marketing
Fisetin is a senotherapeutic that extends health and lifespan
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ · 2018 · EBioMedicine · ~100 mg/kg by oral gavage in intermittent dosing protocols, and ~500 ppm in dietary chow (roughly 500 mg/kg food-equivalent) in lifespan cohorts · Intermittent dosing across remaining lifespan, starting late in life in some cohorts
ingredient-levelpeer-reviewed
Fisetin was the most potent senolytic of 10 flavonoids screened in vitro; oral administration to wild-type mice late in life reduced senescent cell markers, reduced age-related pathology, and extended median and maximum lifespan.
This is mouse/in vitro work, not a human trial, and the effective oral doses used (~100-500 mg/kg body weight) are vastly higher on a per-kg basis than Double Wood's 100 mg flat daily human dose (roughly 1.3-1.7 mg/kg for a 60-80 kg adult), a ~60-300x per-kg gap. Landmark paper; frequently over-cited by supplement brands as if it were human evidence.
Conflicts: None identified; academic/NIH-funded research (Mayo Clinic, Scripps, Buck Institute, Ohio State collaborators)
Source →
Tier 5Mechanistic / animal / marketing
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study (dasatinib + quercetin, methodological precedent for the fisetin pulse-dose trials)
Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Pascual R, Hashmi SK, Prata L, Masternak MM, Kritchevsky SB, Musi N, Kirkland JL · 2019 · EBioMedicine · n=14 · Dasatinib 100 mg/day + quercetin 1250 mg/day for 3 days, repeated every 3 weeks (a different senolytic drug pair, not fisetin, but the same Mayo Clinic research group and same intermittent 'hit-and-run' senolytic dosing philosophy that established the fisetin protocol) · 3 days on / repeated every 3 weeks, for 3 weeks total exposure across the study
ingredient-levelpeer-reviewed
First-in-human pilot senolytic trial; found feasible and tolerable, with improvements in physical function measures in a small, open-label, non-placebo-controlled cohort.
Included for context because this Justice et al. 2019 paper (often loosely cited as 'the 2019 Mayo senolytic trial') established the intermittent hit-and-run dosing paradigm that the Mayo fisetin frailty trials (AFFIRM/AFFIRM-LITE) directly extended to fisetin. It does not test fisetin itself and is not on Double Wood's product.
Conflicts: Academic/NIH funded; several authors are inventors on senolytic-related patents (disclosed in the paper)
Source →
Tier 5Mechanistic / animal / marketing
Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study
Krishnakumar IM, Jaja-Chimedza A, Joseph A, Balakrishnan A, Maliakel B, Swick A · 2022 · Journal of Nutritional Science · 1000 mg unformulated fisetin vs. a fenugreek-galactomannan hybrid-hydrogel formulation delivering only 192 mg of actual fisetin · Single-dose pharmacokinetic crossover, 12-hour sampling window
ingredient-levelpeer-reviewed
Unformulated fisetin at 1000 mg produced Cmax = 9.97 ng/mL and AUC0-12h = 12.67; the hydrogel-encapsulated formulation, despite containing only 192 mg of actual fisetin (~19% of the unformulated dose), produced Cmax = 238.2 ng/mL (about 23x higher) and AUC = 341.4 (about 27x higher), demonstrating that plain, unformulated fisetin (the form Double Wood uses) is very poorly absorbed orally.
Directly relevant: Double Wood's Fisetin is a plain Cotinus coggygria stem extract with no phytosome, liposomal, nanoparticle, or hydrogel delivery technology. Separately, a related nanoformulation review (PMC12234425) cites fisetin's baseline oral bioavailability at approximately 44% due to poor aqueous solubility (~10.45 µg/mL) and high lipophilicity, but functional plasma exposure from an unformulated dose remains very low in absolute terms per this crossover PK study.
Conflicts: Funded by/affiliated with Akay Natural Ingredients and Nutrafol/OmniActive-adjacent industry co-authors (ingredient supplier, not Double Wood); disclosed in the paper
Source →
Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

FisetinFisetin pilot 2024 (biological aging)
FisetinAFFIRM-LITE (NCT03675724)
FisetinYousefzadeh et al. 2018 (preclinical, EBioMedicine)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Unverifiable
“"Fisetin... supports memory and cognitive function as well as acts as a potent antioxidant."”
This is a broad structure/function-style claim with no cited study on the vendor page. Fisetin has documented antioxidant activity in vitro and in animal models, but we found no human RCT establishing that 100 mg/day of unformulated fisetin measurably improves memory or cognition in people. Treat as plausible-mechanism, not clinically demonstrated.
Vendor source
Supported
“"Animal research suggests that Fisetin may be an effective healthy aging support supplement due to its potential as a senolytic, but these results have yet to be established in human trials."”
This is an unusually honest vendor disclaimer and is accurate: the strongest senolytic evidence (Yousefzadeh et al. 2018, PMID 30279143) is mouse/in vitro work, and while Mayo Clinic human trials (NCT03430037, NCT03675724) exist, they use a wildly different dose/pattern (20 mg/kg/day pulse x2 days) than any commercial daily-dose supplement, including this one, so no human trial has validated fisetin senolytic effects at a 100 mg/day chronic dose.
Vendor source
Not supported
“"SENOLYTIC AGENT" (product badge/label claim)”
Labeling the finished 100 mg/day product itself as a 'senolytic agent' overstates the evidence. Fisetin's senolytic classification comes from in vitro screening and mouse studies using doses on the order of 100-500 mg/kg (Yousefzadeh 2018), and the only human trials testing a senolytic-relevant fisetin dose (Mayo Clinic AFFIRM/AFFIRM-LITE) use 20 mg/kg/day for 2 consecutive days, roughly 12-20x Double Wood's daily dose taken in a completely different dosing pattern (pulsed, not daily). No evidence supports 100 mg/day chronic dosing as senolytic in humans.
Vendor source
Partial support
“"ROOTED IN QUALITY", manufactured/tested in USA from globally sourced ingredients, implying rigorous quality control”
Double Wood does offer COAs on request and an independent review found an ISO 17025-accredited third-party potency test specifically for this Fisetin SKU (Colmaric Analyticals). However, the company does not proactively publish batch-specific COAs online, does not test for drug/pharmaceutical contamination by its own admission, and holds no NSF/USP/Informed Sport certification, a mixed picture rather than an unqualified quality guarantee.
Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • The task brief that commissioned this dossier specified a 500 mg/60-capsule Double Wood Fisetin product; no such SKU could be found anywhere (vendor site, Amazon, Target, international retail mirrors). Only a 100 mg/60-capsule SKU exists. This dossier documents the real product.
  • Whether the specific ISO 17025-accredited Colmaric Analyticals COA for Fisetin (reported by suplmnt.app) is still current/available on request as of this review, or was a 2024 snapshot that may not reflect the current batch.
  • Whether Double Wood's 'third-party' testing chain of custody is fully independent of its contract manufacturer, as alleged in a critical Reddit r/Supplements thread, we could not independently confirm or refute this allegation.
  • Exact extraction/standardization method and purity percentage of the Cotinus coggygria stem extract used (e.g., % fisetin content in the raw extract before encapsulation), not disclosed on the label or product page.
  • Whether the product is consistently in stock; as of this review the vendor page showed the product as 'Unavailable'/backordered.
  • Any potential drug interaction warnings (e.g., anticoagulants such as warfarin, per a third-party retailer's label note) are not disclosed on Double Wood's own product page, only inferred from cross-referenced retailer/label copies.
Important to know
FisetinStandard capsules have <5% absorption. Look for liposomal or with piperine.

Editorial notes

Cheapest reputable fisetin at senolytic doses.

Go deeper

Where this sits

Actives inside
Fisetin
Category
See all in Senolytic →
Brand
Double Wood Supplements profile →
Add to compare Visit brand site →
Brand owners

Spot an error?

If you are the manufacturer or brand owner of Fisetin 500 mg and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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All Senolytic →

The next highest-scoring products in Senolytic, same scoring method, same rules.

Revgenetics
MetaQuercetin SuperZ
Senolytic
Active per serving
Quercetin 250 mg+ Zinc 25 mg
Price per serving
$0.68$20.37 · 30 servings
Testing
3rd-party listed · no public lab certificate

Elemental vs compound: check label

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.36
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.revgenetics.com
Renue By Science
Quercetin (Liposomal)
Senolytic
Active per serving
Quercetin 150 mgCapsule · 90 servings
Price per serving
$0.53$47.95 · 90 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

60%
of trial dose
$1.78
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
Double Wood Supplements
Apigenin Supplement
Senolytic
Active per serving
Apigenin 50 mgCapsule · 120 servings
Price per serving
$0.21$24.95 · 120 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.21
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
Same maker

Other products from Double Wood Supplements

Brand profile →
Double Wood Supplements
Alpha Lipoic Acid Supplement
Mitochondrial
Active per serving
Alpha-Lipoic Acid 600 mgCapsule · 30 servings
Price per serving
$0.66$19.95 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.66
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
NAD+ booster
Precursor per serving
NMN 250 mgCapsule · 60 servings
Price per serving
$0.82$48.95 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.63
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
Double Wood Supplements
NMN Powder
NAD+ booster
Precursor per serving
NMN 1,000 mgPowder · 30 servings
Price per serving
$4.33$129.95 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

400%
of trial dose
$2.17
per research-dose day, not label serving
400% · over 2× trial dose0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
Double Wood Supplements
Bacopa Monnieri Extract Supplement
Cognition
Active per serving
Bacopa Monnieri 450 mgCapsule · 90 servings
Price per serving
$0.20$17.95 · 90 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.13
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
Double Wood Supplements
L-Theanine Supplement
Cognition
Active per serving
L-Theanine 200 mgCapsule · 120 servings
Price per serving
$0.17$19.95 · 120 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.17
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com