Which precursor is named. NMN and NR are different molecules and are not interchangeable milligram for milligram.
Whether the milligram figure is per capsule or per serving of several capsules. The catalog records per serving.
Whether a certificate of analysis (CoA) is published for the batch you buy. The catalog only records whether the brand lists one.
Added ingredients (resveratrol, TMG, quercetin) are listed with their own amounts below. Read them separately.
Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.
Editorial score and research-dose calculations
These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.
Watch outEU restricted2 ingredients restricted in the EU
NMN — Unauthorised Novel Food; EFSA positive safety opinion adopted 4 March 2026 at up to 300 mg/day (β-NMN, EffePharm dossier). Commission listing pending.
Spermidine — Novel Food status for concentrates >7 mg; wheat-germ traditional food
You can legally buy these outside the EU. Sale as a food supplement inside the EU requires a Novel Food authorisation these ingredients do not have.
Tier 3
Ingredient RCT (matching dose)
The ingredient was tested in an RCT at the same dose this product sells.
See the 3 supporting studies▾
Uthever RCT 2022(NMN)In 66 adults aged 40-65 over 60 days, NMN (300 mg/day) increased serum NAD+/NADH by 38% versus baseline and improved SF-36 quality-of-life scores compared to placebo. Studied at 300 mg. This product: 300 mg.
Okabe et al. 2022 (Frontiers in Nutrition)(NMN)A 30-person, 12-week RCT found 250 mg/day oral NMN significantly increased whole-blood NAD+ levels with no adverse effects. Studied at 250 mg. This product: 300 mg.
Yi et al. 2023 (GeroScience)(NMN)In an 80-person, 60-day dose-dependent RCT, oral NMN (up to 900 mg/day) significantly raised blood NAD+ levels, was safe and well-tolerated, and improved six-minute walking distance versus placebo. Studied at 900 mg. This product: 300 mg.
How we scored this productShow the full breakdown▾
Dose vs. studies (50%)iWhy 8.0 of 10. Primary ingredient is NMN (evidence grade B). It delivers 300 mg, inside the studied range of 250–900 mg. Read the rule →8.0
Transparency (20%)iWhy 3.0 of 10. Earned points for all doses disclosed. Lost points for no public certificate of analysis and no independent third-party testing. Read the rule →3.0
Value (10%)iWhy 6.2 of 10. One day at the trial dose costs about $2.78. That is more expensive than average (230 of 313 by cost per effective day). Read the rule →6.2
Formulation (10%)iWhy 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule →5.0
Default. No absorption data on file.
Safety (5%)iWhy 5.0 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule →5.0
Community sentiment (5%)iWhy 5.5 of 10. No external reviews found, so community sentiment defaults to neutral. Community never counts as clinical evidence. Read the rule →5.5
CompositeiHow this 5.4 is built. 0.50 × 8.0 + 0.20 × 3.0 + 0.10 × 6.2 + 0.10 × 5.0 + 0.05 × 5.0 + 0.05 × 5.5 = 5.4 out of 10. Safety caps applied after.5.4
5.4composite
Dose vs. studies50%8.0
Transparency20%3.0
Value10%6.2
Formulation10%5.0
Safety5%5.0
Community5%5.5
Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.
This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.
This Lemme Lemme NAD+ scores 6.2, making it below the site average. It delivers 10mg of Lutein, inside the studied range of 10–20mg with grade A evidence (strong human trial data). The quality transparency (3.0) is limited by the lack of third-party testing. At $2.78/day it's among the more expensive options in NAD+ booster.
What drives the score up
Dose-evidence score of 8.0 reflects good alignment with trial doses.
Lutein is dosed at the full research level with grade A evidence (strong human trial data).
Zeaxanthin is dosed at the full research level with grade A evidence (strong human trial data).
Zeaxanthin is also dosed at the full research level.
What drags it down
Resveratrol (100mg is 20% of the 500mg trial dose) is significantly under-dosed.
No third-party testing, which caps the quality transparency.
Quality transparency of 3.0 is below the site average.
Limited consumer feedback (community score: 5.5).
At $2.78/day it's on the expensive side.
Why you'd choose it
You want Lutein from a Lemme product.
You want doses that align with published research.
Why you might skip it
You want third-party verified purity.
You want a product with a publicly available CoA.
You need a full trial dose of resveratrol (this product under-doses it).
Question 1
Does the molecule work?
The science behind each active ingredient, independent of which brand sells it.
A NAD+ building block that has become the most-hyped longevity molecule.
5 landmark RCTs · US: FDA reversed exclusion 29 September 2025; NDIN 1247 and NDIN 1259 reinstated 2 December 2025; NDIN 1444 (β-NMN, Effepharm) response 28 January 2026. NMN is a dietary ingredient again; each marketer still needs NDIN coverage. · EU: Unauthorised Novel Food; EFSA positive safety opinion adopted 4 March 2026 at up to 300 mg/day (β-NMN, EffePharm dossier). Commission listing pending.
A carotenoid concentrated in the eye's macula, backed by the large AREDS2 Phase 3 trial for slowing age-related macular degeneration progression, with additional evidence for cognitive benefits.
1 landmark RCT · US: FDA-recognized dietary supplement ingredient; also used as a color additive in foods; AREDS2 formula is a widely marketed eye-health product category. · EU: Authorized food supplement ingredient with EFSA-reviewed safety assessments; permitted in food fortification as a coloring/nutrient additive.
The companion carotenoid to lutein, co-studied in the landmark AREDS2 trial for slowing age-related macular degeneration progression and supporting cognitive function.
1 landmark RCT · US: FDA-recognized dietary supplement ingredient, typically marketed together with lutein in eye-health formulations. · EU: Authorized food supplement ingredient with EFSA-reviewed safety assessments.
The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.
2 landmark RCTs · US: Dietary supplement · EU: Novel Food status for concentrates >7 mg; wheat-germ traditional food
Full ingredient breakdown
Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.
Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →
Question 2
Is this bottle good?
The specific product: dose, price, transparency, and what buyers report.
Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$2.78/day at trial dose
What one effective daily dose actually costs
Transparency
3.0/10 · No public lab certificate
No third-party testing disclosed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3
What's the catch?
Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.
A carotenoid concentrated in the eye's macula, backed by the large AREDS2 Phase 3 trial for slowing age-related macular degeneration progression, with additional evidence for cognitive benefits.
The companion carotenoid to lutein, co-studied in the landmark AREDS2 trial for slowing age-related macular degeneration progression and supporting cognitive function.
Hard numbers and independently checked status. Expand each block for its source.
The numbers
Price
$50
per bottle · 30 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$2.78
what one effective daily dose costs
$ / g active
$4.04
per gram of active substance
Independently checked
Data verification
COA status
Not public
Evidence grade
BCAAC
Per-ingredient breakdown
BNMN
CResveratrol
ALutein
AZeaxanthin
CSpermidine
All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.
A carotenoid concentrated in the eye's macula, backed by the large AREDS2 Phase 3 trial for slowing age-related macular degeneration progression, with additional evidence for cognitive benefits.
The companion carotenoid to lutein, co-studied in the landmark AREDS2 trial for slowing age-related macular degeneration progression and supporting cognitive function.
NMNAbsorption varies wildly by form. Sublingual and liposomal claim better uptake but human head-to-head data is limited.
Resveratrol"Resveratrol" products that don't specify trans-isomer content are unmeasurable in practice. Cis-resveratrol is biologically inactive.
LuteinFat-soluble compound requiring dietary fat for optimal absorption; excessive doses may cause carotenodermia (yellowish skin discoloration), which is cosmetic and reversible; smokers should be cautious with high-dose beta-carotene combination products (though lutein/zeaxanthin themselves were the AREDS2-preferred alternative specifically due to beta-carotene's lung cancer risk in smokers).
ZeaxanthinAlmost always dosed and studied in combination with lutein rather than alone, so independent effects are hard to isolate; fat-soluble, requiring dietary fat for optimal absorption; generally very well tolerated at studied doses.
SpermidineProduct labels often say 'wheat germ extract 800 mg', that could be 0.8 mg or 8 mg of actual spermidine. Insist on labeled spermidine content.
Editorial notes
Celebrity-founded longevity supplement with NMN, resveratrol, and spermidine. No third-party testing or CoA stated.
If you are the manufacturer or brand owner of Lemme NAD+ and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.
We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.