Basics: short version, verdict first People Molecules Peptides Biomarkers Studies Stem Cells Editorial Methodology
Layer 1 · Decision
← All products

Lipo Berberine

Metabolic · Capsule · 90 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving
Berberine 250 mg
Form
Capsule
List price (catalog, USD)
$49.95
Price per serving
$0.56List price divided by servings per container. A per-day cost only if the label serving is once daily.
Full label record: servings, testing, ingredients
Servings per container
90
Serving size (label)
0.3 g
Catalog monthly estimate
$16.65
Testing disclosure
Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Berberine250 mg

What to check on the label

  • Whether the figure is per capsule or per day, and how many capsules the label's daily serving contains.
  • The salt form named (berberine HCl, dihydroberberine, Ca-AKG). The catalog does not convert between forms.
  • Many labels carry interaction warnings for berberine. Read the label warning and the safety section on this page.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

5.2/10
Overall score
#12 / 20 in Metabolic

Tested by independent lab.

Read the full evidence vault
Watch out
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
How we scored this product Show the full breakdown
Composite How this 5.2 is built. 0.50 × 5.4 + 0.20 × 7.0 + 0.10 × 5.4 + 0.10 × 5.0 + 0.05 × 8.5 + 0.05 × 8.3 = 5.2 out of 10. Safety caps applied after. 5.2
5.2 composite
Dose vs. studies50%5.4
Transparency20%7.0
Value10%5.4
Formulation10%5.0
Safety5%8.5
Community5%8.3

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

5.2 / 10
Best for
Budget-friendly
Avoid if
Only 28% of trial dose, No public lab certificate
Full-dose status
28% of trial dose
Price/month
$17
COA status
Not public
Biggest caveat
Dose-evidence score of 5.4 is below average for the site.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $49.95
Last price check: Sep 01, 2026
Layer 2 · Context
In plain language

Why this scored this way

This Renue By Science Lipo Berberine scores 6.0, making it below the site average. It delivers 250mg of Berberine, 27% of the studied range low edge (900mg) with grade A evidence (strong human trial data). At $3.33/day it's among the more expensive options in Metabolic.

What drives the score up

  • Tested by independent lab (transparency 7.0).
  • Community score of 8.3 with positive consumer feedback.

What drags it down

  • Dose-evidence score of 5.4 is below average for the site.
  • Overall dose is only 28% of the trial dose across ingredients.
  • Berberine (250mg is 17% of the 1500mg trial dose) is significantly under-dosed.
  • No public lab certificate available for independent verification.
  • At $3.33/day it's on the expensive side.

Why you'd choose it

  • You want Berberine from a Renue By Science product.
  • You want a tested by independent lab product.

Why you might skip it

  • You want a product with a publicly available CoA.
  • You need a full trial dose of berberine (this product under-doses it).
  • You want a cheaper option (this is $3.33/day).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Berberine

Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.

1 landmark RCT · US: Dietary supplement · EU: Restricted in Italy (drug status ≥10 mg); food supplement elsewhere
Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
28% of trial dose
Well below the trial dose
Cost at trial dose
$3.33/day at trial dose
What one effective daily dose actually costs
Transparency
7.0/10 · No public lab certificate
Independent batch testing confirmed
Consumer signals
172 reviews across platforms · 4.4/5 · medium confidence
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Safety flag
berberine: CYP3A4 interactions
Dose or interaction risk detected. See ingredient page for details.
No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
Underdosed
Dose at 28% of trial dose
Below 50% of the dose used in published clinical trials.
Buyer complaints
Trustpilot: Occasional shipping complaints; Amazon: Results considered subtle by some
Recurring themes from consumer review platforms.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Berberine250 mgEvidence A

Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.

Read about Berberine →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$50
per bottle · 90 servings
Dose vs. research
Below trial dose 28%
of published effective dose
$ / day at studied dose
$3.33
what one effective daily dose costs
$ / g active
$2.22
per gram of active substance
Independently checked

Data verification

COA status
Not public
Evidence grade
A
Per-ingredient breakdown
ABerberine

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Berberine
Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.
250 mg 17% of trial dose
1500 mg
4.2 /5
High confidence
236 reviews across 4 platforms (5 sources)
Source diversity: 100%
AmazonRedditTrustpilotiHerb
PraiseHigh quality liposomal formulationsReliable delivery
ComplaintsOccasional shipping complaintsResults considered subtle by some
Last checked: 2026-08-20

Consumer signals

4.4 out of 5 across 172 verified reviews on 5 platforms.

Medium confidence

Consumer sentiment compiled from 4 public sources.

172 reviews · 4.4/5 · positive sentiment

PraiseHigh quality liposomal formulationsReliable delivery
ComplaintsOccasional shipping complaints
Themes

Renue By Science's brand-level Trustpilot score (4.4/5) reflects generally satisfied customers.

Compiled from Trustpilot listing located during research; verified at build time.

mixed sentiment

Praise

Noticeable effects during 30-day trial per independent reviewer

ComplaintsResults considered subtle by some
Themes

Independent 30-day review found modest but positive changes from Lipo Berberine.

Compiled from Amazon listing located during research; verified at build time.

positive sentiment

PraiseRanked among best-tested berberine supplementsLiposomal delivery praised for absorption
ComplaintsNot available on iHerb
Themes

BBC Good Food's tried-and-tested roundup rates Renue's Lipo Berberine favorably; not sold on iHerb.

Compiled from iHerb listing located during research; verified at build time.

mixed sentiment

PraiseLab testing confirms label accuracy
ComplaintsDebate over whether liposomal dose is clinically sufficient
Themes

r/Renue members discuss third-party lab verification but continue to debate whether the dose is high enough for real benefit.

Compiled from Reddit listing located during research; verified at build time.

Same brand profile on Trustpilot country sites: France 4.0.

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Important to know
BerberineStandard berberine has ~5% oral bioavailability. Dihydroberberine and berberine phytosomes absorb better. Split doses across meals (500 mg × 3) to avoid GI upset.

Editorial notes

Liposomal berberine HCl (250mg per capsule) for metabolic health and glucose regulation support, verified via SuppCo TrustScore 8.6 (Very Good); ISO 17025-accredited third-party testing and NSF-certified manufacturing. Distinct brand from Renue (existing catalog entry).

Brand owners

Spot an error?

If you are the manufacturer or brand owner of Lipo Berberine and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
Same shelf

Similar products

All Metabolic →

The next highest-scoring products in Metabolic, same scoring method, same rules.

DoNotAge
Metabolic
Active per serving
Berberine 1,500 mgPowder · 30 servings
Price per serving
$1.00$30.00 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.00
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org
Double Wood Supplements
Metabolic
Active per serving
Berberine 500 mgCapsule · 60 servings
Price per serving
$0.33$19.95 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

56%
of trial dose
$1.00
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
Nootropics Depot
Metabolic
Active per serving
Berberine 500 mgCapsule · 60 servings
Price per serving
$0.42$25.00 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

56%
of trial dose
$1.25
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with nootropicsdepot.com
Same maker

Other products from Renue By Science

Brand profile →
Renue By Science
NAD+ booster
Precursor per serving
NMN 500 mgPowder · 200 servings
Price per serving
$0.32$64.95 · 200 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.32
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
Renue By Science
NAD+ booster
Precursor per serving
NMN 250 mgLiposomal capsule · 30 servings
Price per serving
$2.63$79.00 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$5.27
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
NAD+ booster
Precursor per serving
NR 300 mgCapsule · 90 servings
Price per serving
$0.72$64.95 · 90 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.72
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
Renue By Science
NAD+ booster
Ingredients listed
3 ingredients listedlargest listed: NMN 250 mg
Price per serving
$1.42$84.95 · 60 servings
Testing
3rd-party listed · public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.4/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.83
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
Renue By Science
Senolytic
Active per serving
Quercetin 150 mgCapsule · 90 servings
Price per serving
$0.53$47.95 · 90 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

60%
of trial dose
$1.78
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com