What is Berberine-500?

Berberine-500 is a Metabolic supplement by Thorne HealthTech. NO1GEVITY gives it a overall score of 5.9 out of 10.

How much does Berberine-500 cost?

$44.00 for 30 servings. Cost per day at the studied dose is $4.40.

Is Berberine-500 tested by independent lab?

Yes, tested by independent lab. No public lab certificate.

What is the NO1GEVITY score for Berberine-500?

Berberine-500 scores 5.9/10 on the NO1GEVITY composite scale, based on evidence-graded dose (56% of trial dose), transparency, value, consumer signals, and formulation.

Does Berberine-500 match the dose used in clinical studies?

Berberine-500 delivers 56% of the dose used in clinical research, which is below the studied dose.

What is the evidence for Berberine?

Berberine is graded A on the NO1GEVITY evidence scale, meaning strong human evidence from multiple large RCTs (N>500) or meta-analyses confirming a longevity-relevant outcome.

What do consumers say about Berberine-500?

Across 29 verified consumer reviews aggregated by NO1GEVITY, Berberine-500 averages 3.6 out of 5. Sources include Trustpilot, Amazon, iHerb and Labdoor where available.

Layer 1 · Decision

← All products

Thorne HealthTech

Berberine-500

Name: Berberine-500
Brand: Thorne HealthTech
SKU: thorne-berberine-500
Price: 44.0 USD
Availability: InStock
Rating: 3.6 (29 reviews)

Metabolic · Capsule · 30 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Active per serving: Berberine 500 mg
Form: Capsule
List price (catalog, USD): $44.00
Price per serving: $1.47List price divided by servings per container. A per-day cost only if the label serving is once daily.

Full label record: servings, testing, ingredients

Servings per container: 30
Catalog monthly estimate: $44.00
Testing disclosure: Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

Ingredient	Amount per serving
Berberine	500 mg

What to check on the label

Whether the figure is per capsule or per day, and how many capsules the label's daily serving contains.
The salt form named (berberine HCl, dihydroberberine, Ca-AKG). The catalog does not convert between forms.
Many labels carry interaction warnings for berberine. Read the label warning and the safety section on this page.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

5.9/10

Overall score

#9 / 20 in Metabolic

Tested by independent lab.

Read the evidence (1 study)

Add to compare Visit brand site →

Watch out

Tier 3

Ingredient RCT (matching dose)

The ingredient was tested in an RCT at the same dose this product sells.

See the 1 supporting study

Yin et al. 2008 (Metabolism) (Berberine)500 mg × 3/day for 3 months matched metformin for HbA1c reduction in type 2 diabetes. Studied at 500 mg. This product: 500 mg.

How we scored this product Show the full breakdown

Dose vs. studies (50%) 7.2

Transparency (20%) 8.0

Value (10%) 3.9

Formulation (10%) 5.0 Default. No absorption data on file.

Safety (5%) 7.0

Community sentiment (5%) 5.2

Composite 5.9

5.9 composite

Dose vs. studies50%7.2

Transparency20%8.0

Value10%3.9

Formulation10%5.0

Safety5%7.0

Community5%5.2

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Best for

Basic coverage

Avoid if

Only 56% of trial dose, No public lab certificate

Full-dose status

56% of trial dose

Price/month

$44

COA status

Not public

Biggest caveat

Berberine (500.0mg is 33% of the 1500mg trial dose) is significantly under-dosed.

Nearest alternatives

Pure Berberine DoNotAge · Score 8.3
Berberine HCl 500 mg Nootropics Depot · Score 6.8
Berberine Supplement Double Wood Supplements · Score 6.8

Catalog snapshot. Check linked sources for current price, label and batch-specific testing.

Price verification

Current price: $44.00

Last price check: Sep 01, 2026

Add to compare Visit brand site →

Layer 2 · Context

Our summary

Thorne's Berberine-500 combines standard berberine HCl with a phytosome-complexed form in a single 1,000 mg/day (2-capsule) serving, a formulation choice with some support from a phytosome-specific RCT at a nearby dose, though no trial tests this exact dual-form combination directly. Like all berberine products, it delivers real but modest metabolic benefits on glucose and lipids, not the dramatic weight-loss effect implied by the 'Nature's Ozempic' framing that circulated on social media in 2023, which obesity-medicine specialists have explicitly and directly rejected. The product's phytosome-blend positioning is a reasonable bet on absorption technology, but buyers paying a premium for the dual-form claim should know that specific formulation has not been independently validated against simpler, cheaper berberine HCl alone.

In plain language

Why this scored this way

This Thorne HealthTech Berberine-500 scores 6.7, making it a mid-tier product with both strengths and weaknesses. It delivers 500mg of Berberine, 55% of the studied range low edge (900mg) with grade A evidence (strong human trial data). At $4.40/day it's among the more expensive options in Metabolic.

What drives the score up

Dose-evidence score of 7.2 shows decent alignment with trial doses.
Tested by independent lab (transparency 8.0).
Berberine has grade A evidence and is dosed at 55% of the trial dose.

What drags it down

Berberine (500.0mg is 33% of the 1500mg trial dose) is significantly under-dosed.
No public lab certificate available for independent verification.
Limited consumer feedback (community score: 5.2).
At $4.40/day it's on the expensive side.

Why you'd choose it

You want Berberine from a Thorne HealthTech product.
You want a tested by independent lab product.
You want doses that align with published research.

Why you might skip it

You want a product with a publicly available CoA.
You need a full trial dose of berberine (this product under-doses it).
You want a cheaper option (this is $4.40/day).

Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Berberine

Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.

1 landmark RCT · US: Dietary supplement · EU: Restricted in Italy (drug status ≥10 mg); food supplement elsewhere

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research

56% of trial dose

Below the full trial dose

Cost at trial dose

$4.40/day at trial dose

What one effective daily dose actually costs

Transparency

8.0/10 · No public lab certificate

Independent batch testing confirmed

Consumer signals

29 reviews across platforms · 3.6/5 · medium confidence

Operational signal only, never used as clinical evidence

Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Review advised

berberine: CYP3A4 interactions

Safety signals

Drug interaction risk — berberine

Berberine inhibits CYP3A4, CYP2D6, and CYP2C9 even at moderate doses. Documented interactions with immunosuppressants, statins, anticoagulants, and antidiabetic drugs. Consult a physician if taking prescription medications.

Safety flag

berberine: CYP3A4 interactions

Dose or interaction risk detected. See ingredient page for details.

No public lab certificate

Certificate of Analysis not published

Without a public lab certificate, batch purity and potency cannot be independently verified.

Buyer complaints

Trustpilot: poor customer service; Trustpilot: shipping delays

Recurring themes from consumer review platforms.

Plain English

What’s inside

The main ingredients of this product, in plain language.

Berberine500 mgEvidence A

Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.

Read about Berberine →

Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price

$44

per bottle · 30 servings

Dose vs. research

Below trial dose 56%

of published effective dose

$ / day at studied dose

$4.40

what one effective daily dose costs

$ / g active

$2.93

per gram of active substance

Independently checked

Data verification

COA status

Not public

Evidence grade

Per-ingredient breakdown

ABerberine

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient

Dose in this product

Trial dose

Evidence

Berberine

Plant-derived AMPK activator; near-drug-strength effects on blood sugar and lipids.

Yin et al. 2008 (Metabolism)

500 mg 33% of trial dose

1500 mg

2.0 /5

Medium confidence Price exceeds satisfaction

29 reviews across 4 platforms (4 sources)

Source diversity: 92%

AmazonRedditTrustpilotiHerb

Praiseeffective for blood sugar controlgood quality

Complaintspoor customer serviceshipping delays

Last checked: 2026-08-20

Consumer signals

3.6 out of 5 across 29 verified reviews on 5 platforms.

Medium confidence

Consumer sentiment compiled from 4 public sources.

Trustpilot

29 reviews · 1.8/5 · negative sentiment

Complaintspoor customer serviceshipping delays

Themes

Thorne's brand-level Trustpilot score remains poor, primarily due to customer-service and shipping issues.

Compiled from Trustpilot listing located during research; verified at build time.

Amazon

positive sentiment

Praiseeffective for blood sugar controlgood quality

Complaintsone report of small quantity for price (India)

Themes

Most Amazon reviews are positive on effectiveness and quality, with a rare complaint about quantity for price.

Compiled from Amazon listing located during research; verified at build time.

iHerb

positive sentiment

Praisesupports weight managementno stomach upsetpleasant taste

Themes

iHerb reviewers report good tolerability and support for weight management goals.

Compiled from iHerb listing located during research; verified at build time.

3 threads discussed · mixed sentiment

Praiseconsidered a reputable, well-tested option

Complaintsmost expensive option without clearly superior results

Themes

Reddit reviewers rate it as reputable but note it's pricier than alternatives without a clear performance edge.

Compiled from Reddit listing located during research; verified at build time.

Reddit r/Supplements

2 threads discussed · positive sentiment

Themes

frequently compared head-to-head against NOW Foods berberine on formulation and price

appetite suppression and cholesterol management cited as the main reasons people choose it

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site

SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, YesNSF certified, Yes

NIH DSLD registered label

DSLD ID 199415, UPC 6 93749 04800 8

Serving size1-2 Capsule(s)

Servings per container30

Supplement Facts panel, verbatim

Berberine HCl1 Gram(s)

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Innerbody, 'Best Berberine Supplement' roundup

Has affiliate relationship Not a paid placement

Innerbody's 2026 berberine comparison favors other brands over Thorne's for its top recommendation slots, despite Thorne's generally strong manufacturing reputation across its broader catalog.

Finding: Names Double Wood Supplements Berberine as best overall and Toniiq Berberine 97% as runner-up in its 2026 rankings of 7 products; Thorne's Berberine-500 is not named in either top slot.

How we use it: Used for category-context on competitive positioning; not used to make a specific claim about this SKU's dose-efficacy match.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier

Tier 3Ingredient RCT (matching dose)

3 studies mapped

Tier 3Ingredient RCT (matching dose)

Berberine phytosome improves glycaemic control in patients with prediabetes: the HIMABERB randomized controlled trial

HIMABERB Study Investigators · 2023 · Peer-reviewed endocrinology journal (PMC-indexed) · n=34 · 500 mg berberine, 3 times/day (1,500 mg/day total, phytosome formulation) · 12 weeks

ingredient-levelpeer-reviewed

Significant reduction in glycemic markers (fasting glucose, HbA1c) versus baseline/comparator, with no serious adverse events reported.

This trial used a berberine phytosome formulation and total daily dose (1,500 mg/day) very close to Thorne's Berberine-500 label dose components (450 mg HCl + 550 mg phytosome per 2-capsule serving) and to Life Extension's labeled 3x/day regimen (1,530 mg/day total from 3 capsules). Small sample size (n=34) limits statistical power.

Conflicts: Phytosome formulation is a branded ingredient technology; specific trial funding source not disclosed in available summary

Source →

Tier 4Ingredient RCT (different dose)

Efficacy and safety of berberine in the treatment of type 2 diabetes and metabolic syndrome: an updated systematic review and meta-analysis

Multiple (2024/2025 meta-analysis) · 2024 · Peer-reviewed metabolic/endocrinology journal (PMC-indexed) · Varied across pooled trials, generally 900-1,500 mg/day · Varied, generally 8-24 weeks across pooled trials

ingredient-levelpeer-reviewed

Berberine significantly reduced triglycerides (-0.367 mmol/L), fasting glucose (-0.515 mmol/L), waist circumference (-3.27 cm), LDL-C, total cholesterol, BMI (-0.435 kg/m^2, p=0.043), and 2-hour OGTT glucose versus placebo/control; no significant effect on HDL-C or systolic/diastolic blood pressure.

This is the strongest available evidence for berberine's real but modest metabolic effects. The BMI reduction (-0.435 kg/m^2) is the key comparator against GLP-1 agonist weight-loss claims, it is far smaller than what semaglutide (Ozempic/Wegovy) produces, directly undercutting the 'Nature's Ozempic' framing used in TikTok-driven marketing.

Conflicts: Not disclosed in available summary; treated as independent academic meta-analysis absent contrary information

Source →

Tier 5Mechanistic / animal / marketing

Forget TikTok claims: 'Nature's Ozempic' is no such thing, experts say

CNN Health (reporting on expert commentary from Dr. Caroline Apovian, Harvard Medical School, and Dr. Justin Ryder, Northwestern University/Ann & Robert H. Lurie Children's Hospital) · 2023 · CNN · N/A · N/A

ingredient-levelnot peer-reviewed

Dr. Apovian (co-author of Endocrine Society obesity guidelines): 'There is no evidence to support the claim that it is nature's Ozempic.' Dr. Ryder's analysis found berberine reduces BMI by approximately 0.25 points vs. placebo in meta-analysis, compared to semaglutide/Ozempic-class drugs reducing BMI by approximately 4.61 points vs. placebo, roughly an 18-fold difference in effect size for weight loss specifically.

Directly and explicitly contradicts the 'Nature's Ozempic' TikTok framing that both Life Extension's and Thorne's berberine products could be purchased in response to. This is the central claim-check finding for this ingredient across both dossiers in this batch.

Conflicts: None identified, independent medical experts quoted by a news outlet, not sponsored content

Source →

Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

Berberine Yin et al. 2008 (Metabolism)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Not supported

“Berberine is 'Nature's Ozempic', a natural alternative achieving similar metabolic/weight-loss effects to GLP-1 agonist drugs (a claim circulated widely on TikTok and picked up by some retailers/influencers, not necessarily stated verbatim on the brand's own product page)”

Medical experts directly and explicitly reject this framing. Dr. Caroline Apovian (Harvard Medical School, co-author of Endocrine Society obesity guidelines) states plainly: 'There is no evidence to support the claim that it is nature's Ozempic' (https://www.cnn.com/2023/07/04/health/berberine-nature-ozempic-wellness). Meta-analysis data cited in that same reporting shows berberine reduces BMI by roughly 0.25 points versus placebo, while semaglutide-class drugs reduce BMI by roughly 4.61 points versus placebo, an approximately 18-fold difference in weight-loss effect size. Separately, a 2024 meta-analysis confirms berberine's real effects are on triglycerides, fasting glucose, waist circumference, and LDL-C, with only a modest BMI reduction (-0.435 kg/m^2, https://pmc.ncbi.nlm.nih.gov/articles/PMC12307485/), genuine metabolic benefits, but nowhere near GLP-1 agonist potency for weight loss. This is the single most consequential claim-check verdict in this dossier batch: berberine's real evidence base does not support the 'Nature's Ozempic' comparison.

N/A, this is a viral social-media claim (TikTok, 2023) associated with the ingredient category, not a direct quote from this vendor's product page; included per the research brief's explicit instruction to claim-check this framing

Unverifiable

“Dual-form berberine (HCl + phytosome) offers enhanced absorption versus plain berberine HCl”

Phytosome delivery technology has independent pharmacokinetic support for other polyphenol compounds (e.g., curcumin phytosome), and berberine phytosome specifically was used in the positive HIMABERB RCT (https://pmc.ncbi.nlm.nih.gov/articles/PMC10483788/) at a dose close to this product's. However, no head-to-head trial comparing Thorne's specific dual HCl+phytosome blend against plain berberine HCl at matching total doses was located, so the incremental absorption benefit of combining both forms in one capsule (versus either form alone) is not independently confirmed.

Vendor source

Supported

“Supports healthy glucose and lipid metabolism”

This is well supported by the berberine evidence base generally, including the phytosome-specific HIMABERB RCT (https://pmc.ncbi.nlm.nih.gov/articles/PMC10483788/) and the broader 2024 meta-analysis (https://pmc.ncbi.nlm.nih.gov/articles/PMC12307485/), both showing significant glucose and lipid improvements at doses close to this product's label amount.

Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

No public per-batch Certificate of Analysis was located for this specific SKU.
No RCT was located using this exact dual HCl+phytosome blend as the study material; the closest match (HIMABERB) used a phytosome-only formulation at a somewhat higher total dose (1,500 mg/day vs. this product's 1,000 mg/day).
The specific incremental benefit of combining berberine HCl with berberine phytosome in one product, versus either form alone, has not been independently tested.
Drug-interaction risk (statins, anticoagulants, antidiabetics) via CYP3A4/CYP2D6/CYP2C9 inhibition is a real, non-trivial safety consideration not prominently flagged on the vendor's retail page.
Exact meal-timing/split-dosing instructions for the 2-capsule daily serving were not fully confirmed beyond the total per-serving amount.

Important to know

BerberineStandard berberine has ~5% oral bioavailability. Dihydroberberine and berberine phytosomes absorb better. Split doses across meals (500 mg × 3) to avoid GI upset.

Editorial notes

A straightforward 500mg berberine HCl capsule at a dose consistent with the metabolic-health literature (typically 900-1500mg/day in trials, so 2x daily dosing is required to approach study-level intake).

Go deeper

Where this sits

Actives inside

Berberine

Spot an error?

If you are the manufacturer or brand owner of Berberine-500 and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →

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Berberine-500

What the label says

Ingredients as listed

What to check on the label

Quick verdict

Our summary

Why this scored this way

What drives the score up

What drags it down

Why you'd choose it

Why you might skip it

Does the molecule work?

Is this bottle good?

What's the catch?

What’s inside

Product data & verification

The numbers

Data verification

What's inside

Consumer signals

Independent external anchors

What others say, with a source hierarchy

Independent deep reviews, lab tests, certificates of analysis

Evidence, claims & regulation

Evidence, what actually backs this product

Research behind this product

Claim check, vendor claims vs. our reading of the evidence

Regulatory status

What we could not verify

Editorial notes

Where this sits

Spot an error?

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