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Natural Rapalogs

Autophagy · Capsule · 30 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Ingredients listed
5 ingredients listed largest listed: Curcumin 200 mg
Form
Capsule
List price (catalog, USD)
$49.00
Price per serving
$1.63List price divided by servings per container. A per-day cost only if the label serving is once daily.

Reading notes

  • Multi-ingredient product. Amounts are per ingredient per serving; the product is assessed as one bundle, not as a recommendation for each ingredient.
Full label record: servings, testing, ingredients
Servings per container
30
Serving size (label)
1.5 g
Catalog monthly estimate
$49.00
Testing disclosure
No third-party testing listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Curcumin200 mg
EGCG200 mg
Resveratrol100 mg
Fisetin100 mg
Salicin100 mg

What to check on the label

  • Read the spermidine line, not the extract line. '800 mg wheat-germ extract' may contain only a few milligrams of spermidine.
  • Check the serving size. Capsule counts per serving vary from one to three.
  • If wheat-germ based, the label states gluten content. The catalog does not store allergen data.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

3.9/10
Overall score
#25 / 25 in Autophagy

See the score breakdown below.

Read the evidence (2 studies)
Watch out
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 2 supporting studies
How we scored this product Show the full breakdown
Composite How this 3.9 is built. 0.50 × 4.2 + 0.20 × 5.5 + 0.10 × 3.0 + 0.10 × 5.0 + 0.05 × 5.0 + 0.05 × 9.1 = 3.9 out of 10. Safety caps applied after. 3.9
3.9 composite
Dose vs. studies50%4.2
Transparency20%5.5
Value10%3.0
Formulation10%5.0
Safety5%5.0
Community5%9.1

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

3.9 / 10
Best for
Basic coverage
Avoid if
Only 40% of trial dose, No public lab certificate
Full-dose status
40% of trial dose
Price/month
$49
COA status
Not public
Biggest caveat
Dose-evidence score of 4.2 is below average for the site.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $49.00
Last price check: Sep 01, 2026
Layer 2 · Context
In plain language

Why this scored this way

This Supersmart Natural Rapalogs scores 4.7, making it among the lowest-scoring products we track. It delivers 200mg of Curcumin, 40% of the studied range low edge (500mg) with grade B evidence (promising human data, not yet comprehensive). The quality transparency (5.5) is limited by the lack of third-party testing. At $8.17/day it's among the more expensive options in Autophagy.

What drives the score up

  • Community score of 9.1 with positive consumer feedback.

What drags it down

  • Dose-evidence score of 4.2 is below average for the site.
  • Overall dose is only 40% of the trial dose across ingredients.
  • Curcumin (200mg is 20% of the 1000mg trial dose) is significantly under-dosed.
  • Resveratrol (100mg is 20% of the 500mg trial dose) is significantly under-dosed.
  • Fisetin (100mg is 20% of the 500mg trial dose) is significantly under-dosed.

Why you'd choose it

  • You want Curcumin from a Supersmart product.

Why you might skip it

  • You want third-party verified purity.
  • You want a product with a publicly available CoA.
  • You need a full trial dose of curcumin (this product under-doses it).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Curcumin

Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.

4 landmark RCTs · US: GRAS · EU: Food supplement
EGCG

Green tea's active catechin; liver safety caution at high doses.

1 landmark RCT · US: Dietary supplement · EU: Regulated: hepatotoxicity warning ≥800 mg/day
Resveratrol

The famous red-wine molecule; longevity claims have outrun the human evidence.

3 landmark RCTs · US: Dietary supplement · EU: Authorised Novel Food (2016/1866)
Fisetin

Highly-hyped senolytic; the strong evidence is in mice, not people.

3 landmark RCTs · US: Dietary supplement · EU: Food supplement
Salicin

A willow bark compound with mild mTOR-modulating and anti-inflammatory activity; sometimes called a natural rapamycin analog.

1 landmark RCT · US: Dietary supplement · EU: Traditional herbal medicinal product

Full ingredient breakdown

Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.

IngredientDose / servingResearch dose% of researchEvidence grade
Curcumin200 mg1000 mg20%B
EGCG200 mg300 mg67%C
Resveratrol100 mg500 mg20%C
Fisetin100 mg500 mg20%C
Salicin100 mg100 mg100%D

Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
40% of trial dose
Well below the trial dose
Cost at trial dose
$8.17/day at trial dose
What one effective daily dose actually costs
Transparency
5.5/10 · No public lab certificate
No third-party testing disclosed
Consumer signals
9 reviews across platforms · 4.9/5 · medium confidence
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Safety flag
curcumin: CYP3A4 interactions; resveratrol: CYP3A4 interactions; fisetin: warfarin/anticoagulant interaction
Dose or interaction risk detected. See ingredient page for details.
No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
No third-party testing
Independent lab verification not disclosed
The brand does not publish evidence of independent batch testing.
Underdosed
Dose at 40% of trial dose
Below 50% of the dose used in published clinical trials.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Curcumin200 mgEvidence B

Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.

Read about Curcumin →
EGCG200 mgEvidence C

Green tea's active catechin; liver safety caution at high doses.

Read about EGCG →
Resveratrol100 mgEvidence C

The famous red-wine molecule; longevity claims have outrun the human evidence.

Read about Resveratrol →
Fisetin100 mgEvidence C

Highly-hyped senolytic; the strong evidence is in mice, not people.

Read about Fisetin →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$49
per bottle · 30 servings
Dose vs. research
Below trial dose 40%
of published effective dose
$ / day at studied dose
$8.17
what one effective daily dose costs
$ / g active
$2.33
per gram of active substance
Independently checked

Data verification

COA status
Not public
Evidence grade
BCCCD
Per-ingredient breakdown
BCurcumin
CEGCG
CResveratrol
CFisetin
DSalicin

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Curcumin
Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.
200 mg 20% of trial dose
1000 mg
EGCG
Green tea's active catechin; liver safety caution at high doses.
200 mg 67% of trial dose
300 mg
Resveratrol
The famous red-wine molecule; longevity claims have outrun the human evidence.
100 mg 20% of trial dose
500 mg
100 mg 20% of trial dose
500 mg
Salicin
A willow bark compound with mild mTOR-modulating and anti-inflammatory activity; sometimes called a natural rapamycin analog.
100 mg 100% of trial dose
100 mg
4.5 /5
Medium confidence Strong value signal
18,752 reviews across 2 platforms (2 sources)
Source diversity: 46%
Review aggregatorTrustpilot
Praiselarge, well-established review basetrusted supplement retailer
Last checked: 2026-08-20

Consumer signals

4.9 out of 5 across 9 verified reviews on 2 platforms.

Medium confidence

Auto-gathered from public review platforms via pplx_sdk fetch.

18,743 reviews · positive sentiment

Praiselarge, well-established review basetrusted supplement retailer
Themes

SuperSmart's German Trustpilot listing shows an extensive review base (18,743 reviews), reflecting broad customer trust across the brand's anti-aging product line including Natural Rapalogs.

Compiled from a Trustpilot listing located during research; verified at build time.

9 reviews · 4.9/5 · positive sentiment

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say (unverified)

No external reviews aggregated yet for this product.

Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Important to know
CurcuminProducts with just 'turmeric extract' and no branded delivery system are not bioavailable. Ask for the specific bioavailability system.
EGCGTake with food. Avoid on empty stomach. EU restricts high-dose products.
Resveratrol"Resveratrol" products that don't specify trans-isomer content are unmeasurable in practice. Cis-resveratrol is biologically inactive.
FisetinStandard capsules have <5% absorption. Look for liposomal or with piperine.
SalicinDo not combine with NSAIDs or blood thinners. Some people are allergic to salicylates. Quality varies between willow bark extract suppliers.

Editorial notes

Natural mTOR-pathway-modulation complex of five substances (Meriva curcumin phytosome, EGCg, trans-resveratrol, fisetin, salicin from white willow bark) marketed as a non-pharmaceutical 'rapalog' alternative; 3 capsules/day.

Brand owners

Spot an error?

If you are the manufacturer or brand owner of Natural Rapalogs and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
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