Read the spermidine line, not the extract line. '800 mg wheat-germ extract' may contain only a few milligrams of spermidine.
Check the serving size. Capsule counts per serving vary from one to three.
If wheat-germ based, the label states gluten content. The catalog does not store allergen data.
Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.
Editorial score and research-dose calculations
These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 2 supporting studies▾
Vlachojannis 2009 (Phytotherapy Research)(Salicin)Systematic review: willow bark extract equivalent to 120 to 240 mg salicin showed modest analgesic efficacy in low-back pain RCTs. Studied at 240 mg. This product: 100 mg.
EFSA 2018(EGCG)Scientific opinion on green tea catechin safety.
How we scored this productShow the full breakdown▾
Dose vs. studies (50%)iWhy 4.2 of 10. Primary ingredient is Curcumin (evidence grade B). It delivers only 200 mg, 40% of the studied range low edge (500 mg). Under-dosed. Read the rule →4.2
Transparency (20%)iWhy 5.5 of 10. Earned points for all doses disclosed. Lost points for no public certificate of analysis and no independent third-party testing. Read the rule →5.5
Value (10%)iWhy 3.0 of 10. One day at the trial dose costs about $8.17. That is one of the pricier options in the catalog (292 of 313 by cost per effective day). Read the rule →3.0
Formulation (10%)iWhy 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule →5.0
Default. No absorption data on file.
Safety (5%)iWhy 5.0 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule →5.0
Community sentiment (5%)iWhy 9.1 of 10. No external reviews found, so community sentiment defaults to neutral. Community never counts as clinical evidence. Read the rule →9.1
CompositeiHow this 3.9 is built. 0.50 × 4.2 + 0.20 × 5.5 + 0.10 × 3.0 + 0.10 × 5.0 + 0.05 × 5.0 + 0.05 × 9.1 = 3.9 out of 10. Safety caps applied after.3.9
3.9composite
Dose vs. studies50%4.2
Transparency20%5.5
Value10%3.0
Formulation10%5.0
Safety5%5.0
Community5%9.1
Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.
This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.
This Supersmart Natural Rapalogs scores 4.7, making it among the lowest-scoring products we track. It delivers 200mg of Curcumin, 40% of the studied range low edge (500mg) with grade B evidence (promising human data, not yet comprehensive). The quality transparency (5.5) is limited by the lack of third-party testing. At $8.17/day it's among the more expensive options in Autophagy.
What drives the score up
Community score of 9.1 with positive consumer feedback.
What drags it down
Dose-evidence score of 4.2 is below average for the site.
Overall dose is only 40% of the trial dose across ingredients.
Curcumin (200mg is 20% of the 1000mg trial dose) is significantly under-dosed.
Resveratrol (100mg is 20% of the 500mg trial dose) is significantly under-dosed.
Fisetin (100mg is 20% of the 500mg trial dose) is significantly under-dosed.
Why you'd choose it
You want Curcumin from a Supersmart product.
Why you might skip it
You want third-party verified purity.
You want a product with a publicly available CoA.
You need a full trial dose of curcumin (this product under-doses it).
Question 1
Does the molecule work?
The science behind each active ingredient, independent of which brand sells it.
Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.
Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →
Question 2
Is this bottle good?
The specific product: dose, price, transparency, and what buyers report.
Dose vs research
40% of trial dose
Well below the trial dose
Cost at trial dose
$8.17/day at trial dose
What one effective daily dose actually costs
Transparency
5.5/10 · No public lab certificate
No third-party testing disclosed
Consumer signals
9 reviews across platforms · 4.9/5 · medium confidence
Operational signal only, never used as clinical evidence
Question 3
What's the catch?
Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.
Hard numbers and independently checked status. Expand each block for its source.
The numbers
Price
$49
per bottle · 30 servings
Dose vs. research
Below trial dose 40%
of published effective dose
$ / day at studied dose
$8.17
what one effective daily dose costs
$ / g active
$2.33
per gram of active substance
Independently checked
Data verification
COA status
Not public
Evidence grade
BCCCD
Per-ingredient breakdown
BCurcumin
CEGCG
CResveratrol
CFisetin
DSalicin
All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.
SuperSmart's German Trustpilot listing shows an extensive review base (18,743 reviews), reflecting broad customer trust across the brand's anti-aging product line including Natural Rapalogs.
Compiled from a Trustpilot listing located during research; verified at build time.
CurcuminProducts with just 'turmeric extract' and no branded delivery system are not bioavailable. Ask for the specific bioavailability system.
EGCGTake with food. Avoid on empty stomach. EU restricts high-dose products.
Resveratrol"Resveratrol" products that don't specify trans-isomer content are unmeasurable in practice. Cis-resveratrol is biologically inactive.
FisetinStandard capsules have <5% absorption. Look for liposomal or with piperine.
SalicinDo not combine with NSAIDs or blood thinners. Some people are allergic to salicylates. Quality varies between willow bark extract suppliers.
Editorial notes
Natural mTOR-pathway-modulation complex of five substances (Meriva curcumin phytosome, EGCg, trans-resveratrol, fisetin, salicin from white willow bark) marketed as a non-pharmaceutical 'rapalog' alternative; 3 capsules/day.
If you are the manufacturer or brand owner of Natural Rapalogs and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.
We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.