Basics: short version, verdict first People Molecules Peptides Biomarkers Studies Stem Cells Editorial Methodology
Layer 1 · Decision
← All products
Life Extension

GEROPROTECT Ageless Cell

Senolytic · Softgel · 30 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Ingredients listed
4 ingredients listed largest listed: Quercetin 60 mg
Form
Softgel
List price (catalog, USD)
$42.00
Price per serving
$1.40List price divided by servings per container. A per-day cost only if the label serving is once daily.

Reading notes

  • Multi-ingredient product. Amounts are per ingredient per serving; the product is assessed as one bundle, not as a recommendation for each ingredient.
Full label record: servings, testing, ingredients
Servings per container
30
Serving size (label)
0.5 g
Catalog monthly estimate
$42.00
Testing disclosure
Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Fisetin45 mg
Quercetin60 mg
Myricetin40 mg
Curcumin30 mg

What to check on the label

  • Whether the fisetin or quercetin figure is a pure compound amount or an extract standardised to a percentage (for example '98%').
  • How many capsules make a serving and how the label describes use. Monthly cost estimates assume one serving per day.
  • Combination products list each compound below. Amounts are not additive across compounds.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

4.2/10
Overall score
#10 / 10 in Senolytic

Public lab certificate, tested by independent lab.

Read the evidence (1 study)
Add to compareVisit brand site →
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 1 supporting study
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 3.0 of 10. Primary ingredient is Fisetin (evidence grade C). It delivers only 45 mg, 45% of the studied range low edge (100 mg). Under-dosed. Read the rule → 3.0
Transparency (20%) Why 7.5 of 10. Earned points for public certificate of analysis and independent third-party testing and all doses disclosed. Read the rule → 7.5
Value (10%) Why 3.0 of 10. One day at the trial dose costs about $15.56. That is one of the pricier options in the catalog (300 of 313 by cost per effective day). Read the rule → 3.0
Formulation (10%) Why 8.0 of 10. The delivered form has published absorption data showing it works better than the standard version. Read the rule → 8.0
Safety (5%) Why 8.5 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 8.5
Community sentiment (5%) Why 8.6 of 10. Sentiment across 10 external review source(s) is mostly positive. Community is a signal about daily use, not proof of effect. Read the rule → 8.6
Composite How this 4.2 is built. 0.50 × 3.0 + 0.20 × 7.5 + 0.10 × 3.0 + 0.10 × 8.0 + 0.05 × 8.5 + 0.05 × 8.6 = 4.2 out of 10. Safety caps applied after. 4.2
4.2 composite
Dose vs. studies50%3.0
Transparency20%7.5
Value10%3.0
Formulation10%8.0
Safety5%8.5
Community5%8.6

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

4.2 / 10
Best for
Public lab certificate
Avoid if
Only 45% of trial dose
Full-dose status
45% of trial dose
Price/month
$42
COA status
Public
Biggest caveat
Dose-evidence score of 3.0 is below average for the site.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $42.00
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context

Our summary

GEROPROTECT Ageless Cell is a legitimately AI-screened supplement, Life Extension's 2016 collaboration with Insilico Medicine really did use gene-expression-based computational modeling to shortlist NAC, myricetin, and EGCG as candidate 'geroprotectors' in cultured senescent human cells, and that process is documented in a peer-reviewed paper. But the product's placement next to 'senolytic' editorial content and beside Life Extension's own dasatinib/quercetin/fisetin-free 'Senolytic Activator' invites a comparison this formula cannot support: none of Ageless Cell's ingredients have been shown, in a human clinical trial at this product's doses, to clear senescent cells the way dasatinib+quercetin or fisetin have in early human trials. Individually, NAC has the best human evidence (RCTs at 600 mg/day showing reduced senescence markers in obese and older adults, versus 450 mg/day here), while myricetin and gamma-tocotrienol have only in vitro or off-dose human data, and EGCG's dose here (~100 mg/day) sits well below typical trial doses (300-400 mg/day). This is a Tier 5 (mechanistic/in vitro-only for the product's core 'senescence' claim) product with Tier 4 ingredient-level support for select individual compounds at different doses, a scientifically interesting but clinically unproven formula whose marketing language runs meaningfully ahead of what any study, including the company's own foundational research, has actually shown.
In plain language

Why this scored this way

This Life Extension GEROPROTECT Ageless Cell scores 5.0, making it among the lowest-scoring products we track. It delivers 60mg of Quercetin, 24% of the studied range low edge (250mg) with grade B evidence (promising human data, not yet comprehensive). At $15.56/day it's among the more expensive options in Senolytic.

What drives the score up

  • Tested by independent lab (transparency 7.5).
  • Community score of 8.6 with positive consumer feedback.

What drags it down

  • Dose-evidence score of 3.0 is below average for the site.
  • Overall dose is only 45% of the trial dose across ingredients.
  • Fisetin (45mg is 9% of the 500mg trial dose) is significantly under-dosed.
  • Quercetin (60mg is 12% of the 500mg trial dose) is significantly under-dosed.
  • Curcumin (30mg is 3% of the 1000mg trial dose) is significantly under-dosed.

Why you'd choose it

  • You want Quercetin from a Life Extension product.
  • You prioritise tested by independent lab products with public lab certificates.

Why you might skip it

  • You need a full trial dose of fisetin (this product under-doses it).
  • You want a cheaper option (this is $15.56/day).
  • You want a product that hits the full trial dose (this is at 45%).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Fisetin

Highly-hyped senolytic; the strong evidence is in mice, not people.

3 landmark RCTs · US: Dietary supplement · EU: Food supplement
Quercetin

Best-studied 'senolytic' ingredient, though evidence is early.

4 landmark RCTs · US: Dietary supplement · EU: Food supplement (extract-dependent)
Myricetin

Flavonoid from berries and tea with strong lab results on inflammation and metabolism. Human trials do not exist.

1 landmark RCT · US: Dietary supplement · EU: Permitted
Curcumin

Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.

4 landmark RCTs · US: GRAS · EU: Food supplement

Full ingredient breakdown

Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.

IngredientDose / servingResearch dose% of researchEvidence grade
Fisetin45 mg500 mg9%C
Quercetin60 mg500 mg12%B
Myricetin40 mgnot establishedn/aD
Curcumin30 mg1000 mg3%B

Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
45% of trial dose
Well below the trial dose
Cost at trial dose
$15.56/day at trial dose
What one effective daily dose actually costs
Transparency
7.5/10 · Public lab certificate (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

!
Review advised
fisetin: warfarin/anticoagulant interaction; curcumin: CYP3A4 interactions
Safety flag
fisetin: warfarin/anticoagulant interaction; curcumin: CYP3A4 interactions
Dose or interaction risk detected. See ingredient page for details.
Underdosed
Dose at 45% of trial dose
Below 50% of the dose used in published clinical trials.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Fisetin45 mgEvidence C

Highly-hyped senolytic; the strong evidence is in mice, not people.

Read about Fisetin →
Quercetin60 mgEvidence B

Best-studied 'senolytic' ingredient, though evidence is early.

Read about Quercetin →
Myricetin40 mgEvidence D

Flavonoid from berries and tea with strong lab results on inflammation and metabolism. Human trials do not exist.

Read about Myricetin →
Curcumin30 mgEvidence B

Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.

Read about Curcumin →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$42
per bottle · 30 servings
Dose vs. research
Below trial dose 45%
of published effective dose
$ / day at studied dose
$15.56
what one effective daily dose costs
$ / g active
$8.00
per gram of active substance
Independently checked

Data verification

COA status
Public
Evidence grade
CBDB
Per-ingredient breakdown
CFisetin
BQuercetin
DMyricetin
BCurcumin

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
45 mg 9% of trial dose
500 mg
60 mg 12% of trial dose
500 mg
Myricetin
Flavonoid from berries and tea with strong lab results on inflammation and metabolism. Human trials do not exist.
Biomed Pharmacother 2021 review
40 mg
n/a mg
Curcumin
Turmeric's active compound; genuinely anti-inflammatory but only in absorbable forms.
Belcaro et al. 2010Mohseni et al. 2025 (Frontiers in Nutrition)Bahari et al. 2025 (Inflammopharmacology)
30 mg 3% of trial dose
1000 mg
4.3 /5
Medium confidence Strong value signal
719 reviews across 2 platforms (2 sources)
Source diversity: 46%
Examine.comTrustpilot
Last checked: 2026-08-07

Consumer signals

Consumer signals gathered from 2 platforms.

Low confidence, small sample

Consumer sentiment compiled from 1 public source (Examine.com). Small sample size, treat as directional only.

Examine.com

mixed sentiment

Themes

Senolytic evidence in humans is preliminary; blend approach lacks trial data at these doses.

Compiled from an Examine.com listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

719 reviews · 4.3/5

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Trustpilot (lifeextension.com, brand-level, not product-specific)
No affiliate relationship Not a paid placement

Customers overwhelmingly praise product quality, effectiveness claims, delivery speed, and customer service; recurring complaints center on billing/auto-ship issues, occasional empty or damaged capsules, and inconsistent customer-service responsiveness (Life Extension replies to roughly 48-82% of negative reviews depending on region).

Finding: 4.4/5 average ('Excellent') across roughly 300-670 reviews depending on region/snapshot (308 on the primary US domain as of the July 2026 crawl; 665-668 on the German storefront; 381-544 on Canadian/NZ storefronts)
How we use it: This is brand-level sentiment, not a review of Ageless Cell specifically, no Trustpilot reviews naming this exact product were identified. Used only as background on general order-fulfillment and customer-service reliability, not as evidence of product efficacy. Trustpilot reviews are unverified purchaser self-reports and are not a substitute for clinical evidence.
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

iHerb customer reviews (product page)
Has affiliate relationship Not a paid placement

Sparse, generic positive reviews typical of a retailer product page; no methodology, no blinding, no measurement of any biomarker.

Finding: Star rating and review count not fully extracted in this pass; spot-checked reviews were generically positive ('Definitely recommend giving it a try!')
How we use it: Used only to note that consumer sentiment exists and is not negative; explicitly not used as evidence of efficacy given the complete absence of methodology and the retailer's affiliate incentive to display positive reviews prominently.
Swanson Vitamins customer reviews (third-party retailer product page)
Has affiliate relationship Not a paid placement

Small sample retailer star rating with no visible methodology or verified-purchase disclosure standard comparable to Trustpilot's.

Finding: 4.3/5 stars across 43 reviews
How we use it: Directional-only; not weighted meaningfully given N=43 and lack of methodology transparency.
Reddit r/Supplements, 'thoughts on Life Extension's Geroprotect substances'
No affiliate relationship Not a paid placement

Community discussion thread evaluating the GEROPROTECT line's ingredients; representative of the kind of informed-consumer skepticism this dossier's claim_check section formalizes, but not a citable authority.

Finding: No quantitative rating; thread discusses ingredient plausibility
How we use it: Referenced only to confirm that independent skeptical discussion of this exact product exists in public forums; not used to support or refute any specific efficacy claim.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

Examine.com
mixed

Senolytic evidence in humans is preliminary; blend approach lacks trial data at these doses.

Read source → Unverified · we received no payment for this listing
Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 4Ingredient RCT (different dose)
9 studies mapped
Tier 0No source
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
Hickson LJ, Langhi Prata LGP, Bobart SA, et al. (Justice JN senior/coordinating author on the companion IPF senolytics program) · 2019 · EBioMedicine · n=9 · Dasatinib 100 mg + Quercetin 1000 mg orally, once daily for 3 consecutive days ('hit-and-run' dosing) · 3 days of dosing, biopsies at baseline and 11 days after
ingredient-levelpeer-reviewed
This is the landmark human proof-of-concept that a true senolytic drug combination (dasatinib + quercetin, D+Q) reduces measurable senescent-cell burden in human adipose tissue and skin, and lowers circulating SASP factors. This is included here specifically because it is the trial Life Extension's own marketing language ('senolytic-inspired', 'helps clear senescent cells') implicitly trades on. Ageless Cell contains neither dasatinib nor quercetin.
CRITICAL APPLICABILITY NOTE: this trial is NOT evidence for Ageless Cell. It used a prescription tyrosine-kinase inhibitor (dasatinib, sold as Sprycel) plus high-dose quercetin, an ingredient not on the Ageless Cell label at all. The only genuine senolytics with any human trial data (dasatinib+quercetin, fisetin) are absent from this formula. This entry exists to make explicit the gap between the marketing framing and the actual product contents.
Conflicts: NIH- and foundation-funded (Mayo Clinic); none disclosed related to a commercial supplement.
Source →
Tier 0No source
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
Justice JN, Nambiar AM, Tchkonia T, et al. · 2019 · EBioMedicine · n=14 · Dasatinib 100 mg/day + Quercetin 1250 mg/day, 3 consecutive days per week for 3 weeks · 3 weeks (intermittent dosing)
ingredient-levelpeer-reviewed
The other foundational human senolytics study (Justice et al. 2019), again using dasatinib+quercetin, showing feasibility/tolerability and early signals of physical-function improvement in a fibrotic, high senescent-burden disease population.
Same applicability gap as above: this is prescription-drug evidence for D+Q, an entirely different intervention from Ageless Cell's myricetin/NAC/EGCG/tocotrienol blend. Included to make the evidentiary contrast explicit per the research brief.
Conflicts: NIH- and foundation-funded; none disclosed related to a commercial supplement.
Source →
Tier 4Ingredient RCT (different dose)
Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial
Rastgoo S, et al. · 2023 · (Iranian RCT, registered IRCT20220727055563N1) · n=40 · 600 mg/day oral NAC · 4 weeks
ingredient-levelpeer-reviewed
NAC 600 mg/day significantly reduced senescence-associated beta-galactosidase (SA-β-gal) activity and p16/IL-6 gene expression in visceral adipose tissue versus placebo, and improved several inflammatory and glycemic markers. This is genuine human RCT evidence that NAC has measurable senomorphic/anti-inflammatory activity.
Dose (600 mg/day) is close to but slightly higher than Ageless Cell's 450 mg NAC dose. Population (obese bariatric-surgery candidates) is not representative of the general healthy-aging consumer targeted by this product, and the readout is a tissue biomarker, not a functional aging outcome. This is the single strongest piece of ingredient-level human evidence in the entire formula.
Conflicts: None identified; academic/Iranian university funding via IRCT registration.
Source →
Tier 4Ingredient RCT (different dose)
Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial
Rastgoo S, et al. · 2025 · Frontiers in Immunology · n=88 · 600 mg/day NAC, co-administered with 1000 IU or 5000 IU/day vitamin D · 8 weeks
ingredient-levelpeer-reviewed
NAC co-administration further reduced p16 transcript expression in immune cells versus vitamin D alone, though most of the senescence-marker benefit tracked with the vitamin D dose rather than NAC.
Same 600 mg NAC dose as above; again in an older, at-risk (vitamin D-deficient) population, not a matched-dose isolated test of NAC in healthy adults. Supports Tier 4 classification for NAC, not higher.
Conflicts: None identified; Iranian academic/hospital funding.
Source →
Tier 4Ingredient RCT (different dose)
Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications
Semwal DK, et al. (review); primary human data drawn from a 4-week RCT of 'Blueberin' (250 mg blueberry leaf extract + 50 mg myricetin, taken 3x/day) · 2020 · BMC Complementary Medicine and Therapies / cited primary literature · n=42 · 50 mg myricetin (as part of a 300 mg Blueberin blend) taken three times daily = 150 mg myricetin/day total · 4 weeks
ingredient-levelpeer-reviewed
The one placebo-controlled human trial identifiable for myricetin found that a myricetin-containing blueberry-leaf blend significantly reduced fasting plasma glucose and several inflammatory/liver markers in type 2 diabetics.
This is the closest thing to human RCT evidence for myricetin, and the per-dose amount (50 mg) matches Ageless Cell's label, but the total daily exposure in the trial (150 mg/day, split 3x) is 3x higher than Ageless Cell's once-daily 50 mg, in a diabetic population, and measuring glycemic/inflammatory markers rather than senescence or 'anti-aging' endpoints. The authors of the parent review state plainly that clinical trial data on myricetin are 'limited' and further RCTs are 'urgently' needed.
Conflicts: Not disclosed in secondary review; primary Blueberin trial funding not verifiable from this source.
Source →
Tier 4Ingredient RCT (different dose)
Dose dependent elevation of plasma tocotrienol levels and its effect on arterial compliance and plasma total antioxidant status in healthy subjects
Rasool AH, et al. · 2006 · (pharmacology/nutrition journal, PubMed-indexed) · n=36 · Tocotrienol-rich vitamin E (TRE) at 80, 160, or 320 mg/day (mixed tocotrienol isomers, not gamma-tocotrienol alone) · 2 months
ingredient-levelpeer-reviewed
160 mg and 320 mg/day doses produced small, statistically significant reductions in aortic systolic blood pressure; no significant effect on arterial compliance, total antioxidant status (except a modest 9.2% rise at 320 mg), total cholesterol, or LDL-C.
This trial used 80-320 mg/day of mixed tocotrienols. Ageless Cell supplies only 25 mg/day of gamma-tocotrienol specifically, roughly 3-13x lower than the lowest dose tested here, and the isomer mix differs. Effects at the doses actually tested were modest and inconsistent across endpoints even before accounting for the dose gap.
Conflicts: Not disclosed in available abstract.
Source →
Tier 4Ingredient RCT (different dose)
Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: a randomized controlled study
Chin SF, et al. · 2011 · (nutrition journal, cited in tocotrienol.org research compendium) · 160 mg/day tocotrienol-rich fraction (TRF, mixed isomers) · 6 months
ingredient-levelpeer-reviewed
160 mg/day TRF for 6 months improved lipid profile and oxidative status markers versus placebo in healthy older adults.
Again a mixed-isomer TRF dose (160 mg/day) roughly 6x higher than Ageless Cell's 25 mg gamma-tocotrienol-specific dose. Directionally supportive of tocotrienols' cardiometabolic mechanism but not evidence for the dose actually delivered in this product.
Conflicts: Not verifiable from secondary source; original study not independently located on PubMed in this pass.
Source →
Tier 5Mechanistic / animal / marketing
In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state
Aliper A, Belikov AV, Garazha A, Jellen L, Artemov A, Suntsova M, Ivanova A, Venkova L, Borisov N, Buzdin A, Mamoshina P, Putin E, Swick AG, Moskalev A, Zhavoronkov A · 2016 · Aging (Albany NY) · Not applicable, this is the discovery paper behind the product, not a dosing study. In vitro concentrations tested do not correspond to the softgel's oral doses. · Not applicable (cell culture assay)
ingredient-levelpeer-reviewed
This is the actual scientific basis for the product: Life Extension's Andrew Swick co-authored a paper with Insilico Medicine (then based at Johns Hopkins' Emerging Technology Centers) describing a gene-expression-based algorithm (GeroScope) that ranked candidate geroprotector compounds, then tested six of them in senescent human skin fibroblast cultures. NAC, myricetin, and EGCG were among the natural compounds that 'improved several senescence-associated properties' in vitro. This is legitimate mechanistic science, but it is a cell-culture screening study, not a human clinical trial of the finished capsule, or even of these compounds at oral doses.
This is the ingredient-selection paper Life Extension repeatedly cites as the scientific origin of Ageless Cell (confirmed via Insilico Medicine's own 2016 press materials). It establishes plausibility, not efficacy in humans. Andrew Swick (Life Extension's own SVP of scientific affairs) is a co-author, which is a disclosed but real conflict of interest for a paper marketed as independent AI-driven validation.
Conflicts: Co-author Andrew G. Swick was, at time of publication, Life Extension's SVP of Scientific Affairs, Discovery Research and Product Development, i.e., an employee of the company selling the resulting product.
Source →
Tier 5Mechanistic / animal / marketing
Epigallocatechin Gallate (EGCG), Cognitive Vitality for Researchers
Alzheimer's Drug Discovery Foundation (ADDF) Cognitive Vitality summary, citing multiple primary RCTs · 2024 · ADDF research summary (secondary), citing peer-reviewed primary trials · Underlying trials mostly used 300-400 mg EGCG/day (up to 800-1,200 mg/day in some); Ageless Cell's green tea extract supplies roughly 100 mg EGCG/day (223 mg extract standardized to 45% EGCG) · Ranges from 12 weeks to 18 months across cited trials
ingredient-levelpeer-reviewed
Across published human RCTs, EGCG at typical tested doses (300-400 mg/day) has shown modest effects on LDL cholesterol and some antioxidant markers, but two RCTs in multiple sclerosis at 800 mg/day found no clinical benefit, and cancer-prevention trials have not shown protective effects. No human trial has tested EGCG for 'cellular senescence' or aging outcomes directly.
Ageless Cell's EGCG dose (~100 mg/day) is at the low end of, or below, doses used in essentially all cited human RCTs (300-400+ mg/day). This ingredient's inclusion traces to the Aliper 2016 in vitro screening paper, not to any EGCG-specific human aging trial.
Conflicts: Not applicable, secondary summary source; underlying trial COIs not individually re-verified here.
Source →
Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

FisetinFisetin pilot 2024 (biological aging)
FisetinAFFIRM-LITE (NCT03675724)
FisetinYousefzadeh et al. 2018 (preclinical, EBioMedicine)
QuercetinHickson et al. 2019 (senolytics in humans)
QuercetinQuercetin + blood pressure 2016 meta-analysis
QuercetinQuercetin + blood pressure 2022 meta-analysis
QuercetinD+Q pilot trial 2025 (F1000Research)
MyricetinBiomed Pharmacother 2021 review
CurcuminBelcaro et al. 2010
CurcuminMohseni et al. 2025 (Frontiers in Nutrition)
CurcuminBahari et al. 2025 (Inflammopharmacology)
CurcuminKroon et al. 2025 (iScience)

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support
“"GEROPROTECT Ageless Cell uses anti-aging nutrients identified by artificial intelligence to help rejuvenate near-senescent cells and promote cellular rejuvenation and energy"”
The AI-screening claim is verifiably true and well-documented: Life Extension's own Andrew Swick co-authored the underlying 2016 Aging paper with Insilico Medicine describing the GeroScope algorithm that flagged NAC, myricetin, and EGCG (Aliper et al. 2016, PMID 27677171). However, 'helps rejuvenate near-senescent cells' describes an in vitro fibroblast-culture finding, not a demonstrated effect in a person taking the capsule. The claim conflates 'these compounds did something to cells in a dish' with 'this product does something to your cells,' which is a significant and uncited leap.
Vendor source
Not supported
“Implicit/adjacent 'senolytic' positioning, the product page links to an in-house 'Editor's Pick' article titled 'Senolytic Supplements: The Longevity Hack Everyone's Talking About' directly beneath the Ageless Cell listing, and Life Extension markets a companion product literally named 'Senolytic Activator'”
This is the central issue flagged in the research brief. The only human clinical evidence that a compound can act as a true senolytic (selectively killing senescent cells and reducing measurable senescent-cell burden and SASP factors in humans) is for dasatinib+quercetin (Hickson/Justice et al. 2019, PMID 31542391) and, in animal/early human work, fisetin. Ageless Cell contains neither dasatinib, quercetin, nor fisetin, those compounds are reserved for Life Extension's separate 'Senolytic Activator' product. Ageless Cell's actual mechanism, per its own cited science, is 'geroprotection' (mimicking a youthful gene-expression signature in cultured cells), which is a distinct and much weaker claim than 'senolytic.' Placing senolytic editorial content directly on this product's page, without clarifying that this SKU does not contain a tested senolytic compound, is materially misleading.
Vendor source
Unverifiable
“"Encourages the body's healthy process for dealing with senescent [cells]"”
No human trial on this product or its exact ingredient combination measuring actual senescent-cell clearance was located. The claim is phrased vaguely enough ('encourages... healthy process') to avoid a direct efficacy claim, but no evidence, in vitro, animal, or human, was found demonstrating this specific outcome for the finished formula.
Vendor source
Not supported
“"Promotes organ vitality"”
No study, mechanistic, animal, or human, was identified that measured any organ-level outcome for this product or this specific ingredient combination. This is a broad wellness claim with no traceable supporting citation on the vendor page or in the underlying Insilico Medicine research.
Vendor source
Partial support
“"Supports a healthy inflammatory response"”
Individually, NAC (Rastgoo et al. 2023, PMID-pending/PMC10546057) has RCT evidence of reducing IL-6 and hs-CRP at 600 mg/day in obese adults, and EGCG has mechanistic anti-inflammatory activity in vitro and in animal models. No trial tested the combined formula's effect on inflammatory markers, and Ageless Cell's NAC dose (450 mg) is below the 600 mg dose that showed this effect.
Vendor source
Not supported
“"Promotes youthful cellular metabolism"”
This restates the mechanistic hypothesis from the Aliper 2016 in vitro screening paper (mimicking a 'young' gene-expression signature) as if it were a demonstrated outcome of taking the capsule. No human metabolic-outcome data for this product exists.
Vendor source
Supported
“"Formulated by a partnership between Life Extension and Insilico Medicine, Inc."”
Independently confirmed via Insilico Medicine's own 2016-2017 press releases and the peer-reviewed Aliper et al. 2016 Aging paper, which lists a Life Extension employee (Andrew Swick) as co-author (https://www.eurekalert.org/news-releases/463385, https://www.eurekalert.org/news-releases/524562, PMID 27677171). This is one of the few claims on the page that is both specific and independently verifiable.
Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • No published human clinical trial exists on the finished Ageless Cell softgel itself, at its actual combined doses, every piece of supporting evidence is either an in vitro screening study (the Aliper 2016 Aging paper) or ingredient-level trials at different doses and in different (often diseased) populations.
  • The extract standardization of the 50 mg myricetin dose (from Myrica cerifera bark/leaf extract) is not disclosed, it is unclear what percentage of that 50 mg is actual myricetin versus other bark/leaf constituents, making exact potency verification impossible from the label alone.
  • No independent, product-specific lab test (ConsumerLab, Labdoor, or similar) verifying that Ageless Cell softgels actually contain the labeled amounts of NAC, myricetin, EGCG, and gamma-tocotrienol was located in this research pass.
  • Life Extension does not publish a public, per-batch Certificate of Analysis for this SKU; it states COAs are available 'upon request,' which this dossier was not able to independently request and verify.
  • The task brief's stated ingredient list (myricetin, gamma-tocotrienol, hesperetin, NAC, phenylalanine) does not match the current vendor label (Vitamin E, NAC, green tea/EGCG extract, myricetin, gamma-tocotrienol), it is unclear whether this reflects a past reformulation, a different regional SKU, or a brief-drafting error; buyers should verify the label on the specific bottle/region they are purchasing.
  • No data on how much elemental myricetin, EGCG, or gamma-tocotrienol actually survives softgel processing and gastrointestinal absorption was located; bioavailability of myricetin and EGCG in particular is known in the general literature to be low.
Important to know
FisetinStandard capsules have <5% absorption. Look for liposomal or with piperine.
QuercetinPlain quercetin dihydrate has poor absorption. Phytosome forms deliver 10 to 20× more into blood.
MyricetinAny mg number on a label is a guess — there is no validated human dose. Bioavailability is the weak point.
CurcuminProducts with just 'turmeric extract' and no branded delivery system are not bioavailable. Ask for the specific bioavailability system.

Editorial notes

Daily senolytic blend. Senolytic protocol dosing is intermittent, not daily.

Go deeper

Where this sits

Actives inside
FisetinQuercetinMyricetinCurcumin
Category
See all in Senolytic →
Brand
Life Extension profile →
Add to compare Visit brand site →
Brand owners

Spot an error?

If you are the manufacturer or brand owner of GEROPROTECT Ageless Cell and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

We review every request, verify it against primary sources, and publish any accepted change with a dated note. Corrections from brand owners are treated the same as corrections from anyone else: verified before they move.

Request a correction →
Same shelf

Similar products

All Senolytic →

The next highest-scoring products in Senolytic, same scoring method, same rules.

Revgenetics
MetaQuercetin SuperZ
Senolytic
Active per serving
Quercetin 250 mg+ Zinc 25 mg
Price per serving
$0.68$20.37 · 30 servings
Testing
3rd-party listed · no public lab certificate

Elemental vs compound: check label

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.36
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.revgenetics.com
Renue By Science
Quercetin (Liposomal)
Senolytic
Active per serving
Quercetin 150 mgCapsule · 90 servings
Price per serving
$0.53$47.95 · 90 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

60%
of trial dose
$1.78
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
Double Wood Supplements
Fisetin 500 mg
Senolytic
Active per serving
Fisetin 500 mgCapsule · 60 servings
Price per serving
$0.50$30.00 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.50
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
Same maker

Other products from Life Extension

Brand profile →
Omega
EPA and DHA per serving
EPA 700 mg · DHA 500 mgSoftgel · 60 servings
Price per serving
$0.50$30.00 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

70%
of trial dose
$1.43
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
NAD+ booster
Precursor per serving
NR 300 mgCapsule · 30 servings
Price per serving
$0.80$24.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Undisclosed amounts noted

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.80
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Mineral
Mineral per serving
Magnesium 144 mgElemental vs compound: check label
Price per serving
$1.00$30.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

72%
of trial dose
$2.08
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Multi/greens
Ingredients listed
5 ingredients listedlargest listed: Vitamin C 470 mg
Price per serving
$0.41$24.50 · 60 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.43
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Life Extension
Super Ubiquinol CoQ10
Mitochondrial
Active per serving
CoQ10 100 mgSoftgel · 60 servings
Price per serving
$0.62$37.50 · 60 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.25
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com