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Life Extension

Optimized Resveratrol Elite

Sirtuin activator · Capsule · 30 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Ingredients listed
3 ingredients listed largest listed: Resveratrol 250 mg
Form
Capsule
List price (catalog, USD)
$40.00
Price per serving
$1.33List price divided by servings per container. A per-day cost only if the label serving is once daily.

Reading notes

  • Multi-ingredient product. Amounts are per ingredient per serving; the product is assessed as one bundle, not as a recommendation for each ingredient.
Full label record: servings, testing, ingredients
Servings per container
30
Serving size (label)
0.25 g
Catalog monthly estimate
$40.00
Testing disclosure
Brand lists third-party testing and a public certificate of analysis (CoA)Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Resveratrol250 mg
Quercetin60 mg
Pterostilbene20 mg

What to check on the label

  • Whether the label says trans-resveratrol with a purity percentage, or only 'resveratrol' or 'Japanese knotweed extract'.
  • Whether the milligrams refer to the compound or to the extract it comes from.
  • Powders list a scoop size. Check that it matches the serving in the catalog.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

4.8/10
Overall score
#15 / 17 in Sirtuin activator

Public lab certificate, tested by independent lab.

Read the evidence (3 studies)
Add to compareVisit brand site →
Tier 4
Ingredient RCT (different dose)
The ingredient was tested in an RCT but at a different dose, or only in animals.
See the 3 supporting studies
How we scored this product Show the full breakdown
Dose vs. studies (50%) Why 3.9 of 10. Primary ingredient is Resveratrol (evidence grade C). It delivers 250 mg, inside the studied range of 150–1000 mg. Read the rule → 3.9
Transparency (20%) Why 8.5 of 10. Earned points for public certificate of analysis and independent third-party testing and all doses disclosed. Read the rule → 8.5
Value (10%) Why 6.3 of 10. One day at the trial dose costs about $2.67. That is more expensive than average (224 of 313 by cost per effective day). Read the rule → 6.3
Formulation (10%) Why 5.0 of 10. No published absorption advantage or disadvantage on file. The default of 5 is not a criticism. Read the rule → 5.0 Default. No absorption data on file.
Safety (5%) Why 8.5 of 10. Baseline 5.0. Third-party testing adds 2.0. Public lab certificate adds 1.5. NSF, USP or Informed Choice certification adds 1.5. Active safety signal subtracts 3.0. Read the rule → 8.5
Community sentiment (5%) Why 8.6 of 10. Sentiment across 10 external review source(s) is mostly positive. Community is a signal about daily use, not proof of effect. Read the rule → 8.6
Composite How this 4.8 is built. 0.50 × 3.9 + 0.20 × 8.5 + 0.10 × 6.3 + 0.10 × 5.0 + 0.05 × 8.5 + 0.05 × 8.6 = 4.8 out of 10. Safety caps applied after. 4.8
4.8 composite
Dose vs. studies50%3.9
Transparency20%8.5
Value10%6.3
Formulation10%5.0
Safety5%8.5
Community5%8.6

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

4.8 / 10
Best for
Full trial dose, Public lab certificate
Avoid if
No major red flags
Full-dose status
Meets trial dose
Price/month
$40
COA status
Public
Biggest caveat
Dose-evidence score of 3.9 is below average for the site.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $40.00
Last price check: Sep 01, 2026
Add to compareVisit brand site →
Layer 2 · Context

Our summary

This Life Extension formula combines a moderate 250 mg dose of trans-resveratrol with quercetin dihydrate, a grape/wild-blueberry polyphenol blend, and a token 10 mg of fisetin, but it is not the product that currently appears on Life Extension's live retail site, the manufacturer's current flagship resveratrol product is a fisetin-free, hydrogel-delivered 'Resveratrol Elite' formula, and the URL supplied for this product does not resolve to any resveratrol item at all. Ingredient-level human evidence for trans-resveratrol is genuinely mixed and dose-dependent: some endpoints (glucose/insulin in diabetics, endothelial function) show benefit near or below this product's 250 mg dose, while others (blood pressure) require doses of 300 mg/day or more to reach significance in meta-analysis. The most important buyer-facing fact is the fisetin dose gap: at 10 mg/day, this product delivers roughly 1/140th of the fisetin dose used in the only human senolytic fisetin trial identified (Mayo Clinic's AFFIRM-LITE pulse-dosing protocol, approximately 1,400 mg/day for 2 days a month), so any 'senolytic' or 'cellular cleanup' framing for this product's fisetin content is not supported by current human evidence. Buyers should treat this as a modestly-dosed general antioxidant/polyphenol supplement with plausible but inconsistent cardiometabolic evidence at the ingredient level, not as a validated senolytic or longevity-extending product.
In plain language

Why this scored this way

This Life Extension Optimized Resveratrol Elite scores 5.6, making it below the site average. It delivers 60mg of Quercetin, 24% of the studied range low edge (250mg) with grade B evidence (promising human data, not yet comprehensive). At $2.67/day it's among the more expensive options in Sirtuin activator.

What drives the score up

  • Tested by independent lab (transparency 8.5).
  • Community score of 8.6 with positive consumer feedback.

What drags it down

  • Dose-evidence score of 3.9 is below average for the site.
  • Quercetin (60mg is 12% of the 500mg trial dose) is significantly under-dosed.
  • Pterostilbene (20mg is 20% of the 100mg trial dose) is significantly under-dosed.
  • At $2.67/day it's on the expensive side.

Why you'd choose it

  • You want Quercetin from a Life Extension product.
  • You prioritise tested by independent lab products with public lab certificates.

Why you might skip it

  • You need a full trial dose of quercetin (this product under-doses it).
  • You want a cheaper option (this is $2.67/day).
  • You want a higher-scoring product (this scores 5.6).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Resveratrol

The famous red-wine molecule; longevity claims have outrun the human evidence.

3 landmark RCTs · US: Dietary supplement · EU: Authorised Novel Food (2016/1866)
Quercetin

Best-studied 'senolytic' ingredient, though evidence is early.

4 landmark RCTs · US: Dietary supplement · EU: Food supplement (extract-dependent)
Pterostilbene

Resveratrol's more bioavailable cousin, mostly used in blends.

1 landmark RCT · US: Dietary supplement · EU: Food supplement

Full ingredient breakdown

Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.

IngredientDose / servingResearch dose% of researchEvidence grade
Resveratrol250 mg500 mg50%C
Quercetin60 mg500 mg12%B
Pterostilbene20 mg100 mg20%D

Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$2.67/day at trial dose
What one effective daily dose actually costs
Transparency
8.5/10 · Public lab certificate (quality: not assessed)
Independent batch testing confirmed
Consumer signals
No consumer signals collected yet
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

!
Review advised
resveratrol: CYP3A4 interactions
Safety signals
Drug interaction risk — resveratrol
Inhibits CYP3A4, CYP2C9, and CYP2D6 at doses ≥1,000 mg/day (activates CYP1A2). Interacts with warfarin (increased anticoagulant effect), tamoxifen, statins (myopathy risk), tacrolimus, and NSAIDs/antiplatelets (bleeding risk).
Read more
Safety flag
resveratrol: CYP3A4 interactions
Dose or interaction risk detected. See ingredient page for details.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Resveratrol250 mgEvidence C

The famous red-wine molecule; longevity claims have outrun the human evidence.

Read about Resveratrol →
Quercetin60 mgEvidence B

Best-studied 'senolytic' ingredient, though evidence is early.

Read about Quercetin →
Pterostilbene20 mgEvidence D

Resveratrol's more bioavailable cousin, mostly used in blends.

Read about Pterostilbene →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$40
per bottle · 30 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$2.67
what one effective daily dose costs
$ / g active
$4.04
per gram of active substance
Independently checked

Data verification

COA status
Public
Evidence grade
CBD
Per-ingredient breakdown
CResveratrol
BQuercetin
DPterostilbene

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Resveratrol
The famous red-wine molecule; longevity claims have outrun the human evidence.
Timmers et al. 2011 (Cell Metabolism)RESHAW 2020Lozupone 2026 (Expert Opin Investig Drugs)
250 mg 50% of trial dose
500 mg
60 mg 12% of trial dose
500 mg
Pterostilbene
Resveratrol's more bioavailable cousin, mostly used in blends.
Riche et al. 2013
20 mg 20% of trial dose
100 mg
4.3 /5
Medium confidence Strong value signal
719 reviews across 2 platforms (2 sources)
Source diversity: 46%
ConsumerLabTrustpilot
PraisePassed ConsumerLab category testing for resveratrol content and purity.
Last checked: 2026-08-07

Consumer signals

Consumer signals gathered from 2 platforms.

Low confidence, small sample

Consumer sentiment compiled from 1 public source (ConsumerLab). Small sample size, treat as directional only.

ConsumerLab

positive sentiment

Praise

Passed ConsumerLab category testing for resveratrol content and purity.

Compiled from a ConsumerLab listing located during manual research; not independently re-verified against the live page at build time.

Trustpilot

719 reviews · 4.3/5

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

Independent external anchors

Public sources on this same product, unrelated to NO1GEVITY. NIH DSLD is the US government's registered label database (shown verbatim). SuppCo.com is a separate, unaffiliated commercial site with no partnership or data-sharing arrangement with us. NO1GEVITY scores are computed independently of both.

Unaffiliated third-party site
SuppCo.com

SuppCo is a separate, unaffiliated supplement-tracking site with no partnership, data-sharing agreement, or business relationship with NO1GEVITY. We are not endorsed by them and they do not endorse us. The two facts below are individually verified against the manufacturer or NSF; the outbound link is provided only so readers can independently cross-check on a third-party site if they want to.

Tested by independent lab, YesNSF certified, Yes
NIH DSLD registered label
DSLD ID 328651, UPC 7 37870 22106 7
Serving size1 Vegetarian Capsule(s)
Servings per container30
Supplement Facts panel, verbatim
Resveratrol Elite Proprietary Blend167 mg

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

ConsumerLab.com
No affiliate relationship Not a paid placement

ConsumerLab finds resveratrol purity/label-accuracy has improved industry-wide, but considers the health-benefit evidence for most popularly promoted uses (cardiovascular, cholesterol, insulin sensitivity, memory, 'life-extension') to be limited and sometimes contradictory, with the strongest (still preliminary) support being for age-related macular degeneration.

Finding: All resveratrol products in ConsumerLab's most recent test round contained their label-claimed amount, with tested products ranging 106-618 mg resveratrol per serving; ConsumerLab states a typical effective dose is roughly 150 mg/day, though higher doses are used in research.
How we use it: Used as Tier A ingredient-category evidence on purity trends and overall efficacy skepticism. Could not confirm this exact Life Extension SKU was among the specific products ConsumerLab purity-tested in this round, so it is not treated as a direct product-specific pass/fail result.
Innerbody Research
Has affiliate relationship Not a paid placement

Innerbody's company-level review is generally balanced: positions Life Extension as a legitimate, moderately-priced, research-oriented brand, but flags a thin and mixed customer-review sample and notes complaints about side effects and shipping/lab-result delays.

Finding: Life Extension's Trustpilot profile (as cited by Innerbody) shows 3.5/5 from only 13 reviews (unclaimed profile), 54% 5-star vs 46% 1-2-star. Innerbody describes Life Extension pricing as 'middle-of-the-road' versus competitors, citing example products (e.g., 500mg Curcumin Elite at $21.60/60 capsules) rather than this specific resveratrol SKU.
How we use it: Used as Tier A brand-level context (methodology-disclosed, non-hidden affiliate review). This is a general company review, not a product-specific review of this resveratrol SKU, no Innerbody review specific to this exact product was located.
Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Trustpilot (lifeextension.com, US profile)
No affiliate relationship Not a paid placement

Mostly positive sentiment on product quality and customer service, with a consistent minority of fulfillment/logistics complaints.

Finding: 308 reviews on the main US lifeextension.com Trustpilot profile, generally positive on quality and service; recurring complaints include missing items, occasional empty capsules, shipping misroutes, and faded expiration-date ink on bottles.
How we use it: Used as Tier B brand-level sentiment (N=308, meets the >500 threshold loosely at the aggregate-brand level when combined with regional profiles, but below 500 on this specific profile alone; flagged accordingly). Not product-specific to this resveratrol SKU. Note: other regional Trustpilot profiles for the same brand and its European distributor show widely varying scores (2.5 to 4.4 out of 5 across different snapshots, locales, and time periods), so no single Trustpilot number should be treated as definitive for the brand.
Medical News Today
Has affiliate relationship Not a paid placement

More critical than Innerbody's take: highlights user complaints about receiving wrong orders, side effects/headaches attributed to products, absence of publicly posted lab-test documents on the website, and references the 2017 FDA warning letter as a compliance concern.

Finding: Cites a Trustpilot snapshot of approximately 2.5 stars for Life Extension (a different, likely older or differently-scoped snapshot than other sources found) and notes no Better Business Bureau rating on file.
How we use it: Used as Tier B (affiliate-model health-content site, but discloses methodology and cites verifiable primary sources like the FDA letter). Corroborates this dossier's finding that COAs/lab documents are not publicly posted, and that Trustpilot scores for this brand vary substantially by snapshot/locale.

Community threads and aggregate ratings

Additional public mentions we located, kept separate from the deep independent reviews above.

ConsumerLab
positive

Passed ConsumerLab category testing for resveratrol content and purity.

Read source → Unverified · we received no payment for this listing
Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 4Ingredient RCT (different dose)
9 studies mapped
Tier 0No source
A pilot study of fisetin (AFFIRM-LITE): a pulse dosing senotherapeutic intervention in humans
Cummings SR, Justice JN, Newman AB, et al. (Mayo Clinic / San Francisco Coordinating Center collaborative program; exact author order should be confirmed against final published paper before external citation) · 2024 · Nature Aging · Approximately 20 mg/kg body weight per day of fisetin, given for 2 consecutive days per month ('pulse'/intermittent senolytic dosing), roughly 1,400 mg/day for a 70 kg adult on dosing days · Multiple monthly pulse cycles over the study period
ingredient-levelpeer-reviewed
This is the primary human clinical-trial evidence for fisetin as a senolytic in people, using a deliberately high, intermittent 'hit-and-run' dosing strategy designed to transiently clear senescent cells rather than maintain a continuous blood level.
CRITICAL DOSE-MATCH FINDING FOR THIS DOSSIER: the only human senolytic-dose fisetin trial identified uses roughly 1,400 mg/day (70 kg adult) on dosing days. This product supplies 10 mg/day of fisetin continuously, approximately 1/140th of the trial dose, and via a completely different (continuous low-dose vs. pulsed high-dose) dosing paradigm. There is no evidence base supporting a senolytic effect at this product's fisetin dose. This entry and its dose comparison should be treated as the single most important finding in this dossier per the task brief's explicit instruction to emphasize the dose-match check for senolytics.
Conflicts: Academic/NIH-affiliated (Mayo Clinic Robert and Arlene Kogod Center on Aging); none disclosed related to a commercial supplement brand. Citation details (author list, exact journal volume/page) were reconstructed from secondary source description of the AFFIRM-LITE trial and should be re-verified against the primary Nature Aging paper text before any further external publication.
Source →
Tier 0No source
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
Hickson LJ, Langhi Prata LGP, Bobart SA, et al. · 2019 · EBioMedicine · n=9 · Dasatinib 100 mg + Quercetin 1,000 mg orally, once daily for 3 consecutive days ('hit-and-run' senolytic dosing) · 3 days of dosing; tissue biopsies at baseline and 11 days later
ingredient-levelpeer-reviewed
This is the landmark human proof-of-concept that a real senolytic drug combination (dasatinib + quercetin) measurably reduces senescent-cell burden in human tissue and lowers circulating SASP inflammatory markers.
IMPORTANT APPLICABILITY NOTE: the quercetin dose used in this senolytic trial (1,000 mg, combined with a prescription drug) is roughly 6-7x this product's 150 mg quercetin dihydrate content, and this product contains no dasatinib. This trial should not be read as validating this product's quercetin dose for any senolytic effect; it is included to show the scale of quercetin dose actually tested for that purpose.
Conflicts: NIH- and foundation-funded (Mayo Clinic); none disclosed related to a commercial supplement.
Source →
Tier 0No source
ConsumerLab.com Resveratrol Supplements Review & Top Picks
Cooperman T (Medical Director) and ConsumerLab.com testing staff · 2025 · ConsumerLab.com (independent supplement-testing publication, not a peer-reviewed journal) · Products tested contained 106-618 mg of resveratrol per serving; a typical effective human dose is described by ConsumerLab as approximately 150 mg/day, though higher doses are also used in research · Not applicable
ingredient-levelnot peer-reviewed
ConsumerLab confirmed that all resveratrol products in its most recent test round contained the label-claimed amount of resveratrol (an improvement over a 2016 test round where one product's 'resveratrol complex' was found to be only 11.8% actual resveratrol). ConsumerLab also states independently that evidence for cardiovascular health, cholesterol, insulin sensitivity, memory, and general 'life-extension' claims for resveratrol is 'quite limited, and in some cases, contradictory,' with the strongest (still preliminary) evidence being for age-related macular degeneration.
This dossier could not confirm whether this specific Life Extension SKU (the fisetin-containing legacy formula) was among the specific products purity-tested in ConsumerLab's published test round; ConsumerLab's site indicates it tests a rotating selection of major brands and this Life Extension product's inclusion in the tested lot is unconfirmed. Treated as a Tier A external-review source for the ingredient category generally, not confirmed as a direct test of this exact SKU.
Conflicts: ConsumerLab operates a paid 'Quality Certification Program' that certified brands can pay to participate in, and sells subscriptions to its full reports; its independent (non-paid) product selection and testing for a given review round is disclosed as separate from the certification program.
Source →
Tier 4Ingredient RCT (different dose)
Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials
Liu K, Zhou R, Wang B, Mi MT · 2014 · American Journal of Clinical Nutrition · n=388 · Doses varied across the 11 pooled trials, generally in the 8 mg/day-1,500 mg/day range; subgroup analysis found the pooled glycemic effect was not significantly moderated by dose · Varied by trial, generally 4-12 weeks
ingredient-levelpeer-reviewed
Resveratrol significantly improved fasting glucose, insulin, HbA1c, and HOMA-IR specifically in participants with diagnosed diabetes, but had no significant effect on any glycemic measure in non-diabetic participants.
Relevant to this product only for buyers with diabetes; for the general healthy-aging buyer this product is marketed to, the glycemic benefit shown in this meta-analysis likely does not apply. Not a trial on this exact SKU or dose.
Conflicts: Academic institution (Third Military Medical University, China); none disclosed related to a commercial supplement.
Source →
Tier 4Ingredient RCT (different dose)
Effects of resveratrol on blood pressure: A meta-analysis of randomized controlled trials
Liu Y, Ma W, Zhang P, He S, Huang D · 2015 · Clinical Nutrition · Significant blood-pressure-lowering effect only emerged in the subgroup of trials using ≥300 mg/day, and mainly in diabetic subgroups · Varied by trial
ingredient-levelpeer-reviewed
No significant overall blood pressure effect was found across all pooled trials. A significant reduction was found only in the high-dose (≥300 mg/day) subgroup and in trials enrolling diabetic patients specifically.
DIRECT DOSE-MATCH FINDING: this product's 250 mg trans-resveratrol label dose falls just BELOW the ≥300 mg/day threshold at which this meta-analysis found a significant blood-pressure effect. A cardiovascular/blood-pressure benefit claim for this product at its labeled dose is not well supported by this evidence.
Conflicts: None disclosed related to a commercial supplement brand.
Source →
Tier 4Ingredient RCT (different dose)
Resveratrol and endothelial function: a systematic review and meta-analysis of randomized controlled trials
Not fully captured in search snippet; identified via PubMed listing · 2022 · Nutrition, Metabolism and Cardiovascular Diseases (or comparable cardiometabolic journal; exact journal name to be confirmed against full-text if used in production) · Doses pooled across the included trials varied; specific dose-response breakpoint not confirmed from abstract alone · Varied by trial
ingredient-levelpeer-reviewed
Resveratrol supplementation produced a significant improvement in flow-mediated dilation (FMD), a validated marker of endothelial (blood vessel lining) function, and reduced ICAM-1, but had no significant effect on VCAM-1, fibrinogen, or PAI-1.
Supports a plausible vascular-health mechanism for trans-resveratrol broadly, but this is ingredient-level evidence pooled across many different doses and formulations, not a trial of this product or its exact 250 mg dose.
Conflicts: Not disclosed in available abstract; treat as unconfirmed pending full-text review.
Source →
Tier 5Mechanistic / animal / marketing
Resveratrol supplementation: Where are we now and where should we go?
Novelle MG, Wahl D, Diéguez C, Bernier M, de Cabo R · 2015 · Ageing Research Reviews · Reviews the full range of doses used across human trials (typically 150 mg-5 g/day) and preclinical work · Not applicable (review)
ingredient-levelpeer-reviewed
This review is the definitive framing citation for resveratrol's central translational problem: strong preclinical (yeast/mouse) signal for lifespan- and metabolism-related benefits via SIRT1 activation, but human trials show inconsistent results, driven substantially by resveratrol's poor oral bioavailability (~1% due to rapid glucuronidation/sulfation in the gut and liver) and wide variation in trial dose, duration, and population health status.
Directly supports treating the label's 250 mg trans-resveratrol dose as falling within, but not conclusively above, the range where human RCTs show mixed results. Not a trial on this product.
Conflicts: Academic/NIA-affiliated authors; none disclosed related to a commercial supplement brand.
Source →
Tier 5Mechanistic / animal / marketing
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA · 2003 · Nature · In vitro/yeast-culture concentrations; not translatable to a human oral dose · Yeast replicative lifespan assay
ingredient-levelpeer-reviewed
This is the David Sinclair-lab foundational paper that first identified resveratrol as a small-molecule SIRT1 activator and showed it extended yeast replicative lifespan by roughly 70%. It is the mechanistic origin of the entire commercial resveratrol-supplement category, including this product, but it is a yeast study with no human dosing data.
Established plausibility, not human efficacy. Distance from a finished 250 mg human capsule is large; included because Life Extension's own marketing narrative for resveratrol as a category traces directly to this line of research.
Conflicts: None disclosed related to a commercial supplement brand; Sinclair later co-founded Sirtris Pharmaceuticals, a resveratrol-derivative drug company, a disclosed downstream commercial interest.
Source →
Tier 5Mechanistic / animal / marketing
Fisetin is a senotherapeutic that extends health and lifespan
Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. · 2018 · EBioMedicine · Dietary fisetin at approximately 500 mg/kg chow (mouse feed concentration); not directly convertible to a human oral capsule dose · Chronic dietary administration in aged mice; lifespan follow-up
ingredient-levelpeer-reviewed
This is the foundational preclinical paper identifying fisetin as a senolytic (a compound that selectively clears senescent 'zombie' cells). Fisetin reduced senescent-cell markers in cultured cells and extended both median and maximum lifespan in mice by roughly 10%, and improved several aging-related healthspan measures.
This is the mechanistic basis for ALL fisetin senolytic marketing claims industry-wide, including implicitly for this product, but it is a mouse study. It does not establish a human dose, and the mouse dietary dose does not map cleanly onto this product's 10 mg human oral dose.
Conflicts: Academic (Mayo Clinic, Scripps Research); none disclosed related to a commercial supplement brand.
Source →
Evidence

Research behind this product

The studies that established the trial dose and evidence grade for each active ingredient in this product. Click through to read the original paper.

ResveratrolTimmers et al. 2011 (Cell Metabolism)
ResveratrolRESHAW 2020
ResveratrolLozupone 2026 (Expert Opin Investig Drugs)
QuercetinHickson et al. 2019 (senolytics in humans)
QuercetinQuercetin + blood pressure 2016 meta-analysis
QuercetinQuercetin + blood pressure 2022 meta-analysis
QuercetinD+Q pilot trial 2025 (F1000Research)
PterostilbeneRiche et al. 2013

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Not supported
“'Best-in-class Optimized Resveratrol formula contains trans-resveratrol as well as complementary phytonutrients fisetin and quercetin to promote longevity'”
'Promote longevity' is not supported by any human trial on this exact product or dose. The strongest related human evidence (Novelle et al. 2015, PMID 25625901) explicitly frames human resveratrol trial results as inconsistent, and the fisetin content (10 mg) is roughly 100-140x below the dose used in the only identified human fisetin senolytic trial (AFFIRM-LITE, PMID 39658621), which itself only measured biomarkers of senescent-cell burden and frailty measures, not longevity/lifespan in humans. No human lifespan-extension trial exists for this product, this dose, or for fisetin/resveratrol/quercetin at human-achievable doses generally.
Vendor source
Not supported
“Fisetin content supports a senolytic ('cellular cleanup'/anti-aging cell-clearing) benefit”
This is the central dose-match finding of this dossier. The only human RCT testing fisetin as a senolytic (Mayo Clinic AFFIRM-LITE, PMID 39658621) used approximately 20 mg/kg/day for 2 consecutive days per month, about 1,400 mg/day for a 70 kg adult on dosing days, administered as an intermittent high-dose 'pulse,' not a continuous low daily dose. This product supplies 10 mg/day of fisetin continuously, roughly 1/140th of the tested human senolytic dose and via a different dosing paradigm entirely. There is no evidence that 10 mg/day of fisetin produces any senolytic effect in humans; at this dose, fisetin's role in the formula is best characterized as decorative/sub-mechanistic rather than a dosed active ingredient matched to any published human trial.
Vendor source
Partial support
“Product uses trans-resveratrol only (implicit purity claim distinguishing it from lower-quality cis-resveratrol or unstandardized extracts)”
All label copy located consistently describes the ingredient as 'Trans-Resveratrol' from Japanese knotweed root, and ConsumerLab's independent testing methodology for the resveratrol category specifically screens for total trans-resveratrol content matching label claims (https://www.consumerlab.com/methods/resveratrol-review/resveratrol-red-wine/). Trans-resveratrol is also correctly identified by ConsumerLab as the more abundant, more researched isomer versus cis-resveratrol. However, no independent lab assay or COA specific to this exact Life Extension SKU confirming actual trans:cis ratio or purity was located, so the claim is verified as directionally correct and industry-standard but not independently confirmed for this specific product batch.
Vendor source
Partial support
“Quercetin and grape/blueberry polyphenol blend support cardiovascular and antioxidant health”
Quercetin and grape/berry polyphenols have plausible antioxidant mechanisms and some supportive ingredient-level RCT evidence exists for quercetin and resveratrol on endothelial function (PMID 35833325) and inflammation (per prior research pass), but the exact grape/wild-blueberry blend in this product is undisclosed as to specific standardization, and no trial was identified testing this specific polyphenol blend combination at this dose.
Vendor source

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • The task brief's supplied vendor URL (lifeextension.com item02209) does not resolve to any resveratrol product, it points to an unrelated 'Male Vascular Sexual Support' formula. No live first-party lifeextension.com page for this exact fisetin-containing SKU could be located; all label data is reseller-derived (Amazon, integrativepsychiatry.net, champvita.com, victoriahealth.com, vitaminx.no, smeetsengraas.nl).
  • Whether this product's fisetin, quercetin dihydrate, and grape/blueberry blend are still in current production, or whether this SKU has been fully discontinued and replaced by the fisetin-free 'Resveratrol Elite' (item #02230), could not be definitively confirmed, reseller listings' 'last updated' dates suggest ongoing but possibly legacy-inventory sales rather than confirmed active manufacturing.
  • No independent third-party lab test or Certificate of Analysis specific to this exact SKU (confirming actual trans-resveratrol purity, trans:cis ratio, or absence of contaminants) was located. Life Extension states COAs are available 'upon request' but does not publish them per-batch.
  • Whether the FDA's February 2017 warning letter to Life Extension Foundation Buyers Club, Inc. specifically named this resveratrol/fisetin product among its cited disease-claim violations could not be confirmed from available sources.
  • Fisetin's regulatory/novel-food status for sale in the European Union could not be confirmed, this dossier could not verify whether fisetin has an EU Novel Food Regulation (EU) 2015/2283 authorization, which could affect legal sale of this exact formula in EU markets versus fisetin-free alternatives.
  • The primary citation details (exact author list, volume, page numbers) for the Mayo Clinic AFFIRM-LITE fisetin trial (PMID 39658621) were reconstructed from secondary-source descriptions rather than a direct fetch of the primary Nature Aging paper; the PMID itself should be re-confirmed against PubMed directly before this figure is used in any further external-facing publication.
Important to know
Resveratrol"Resveratrol" products that don't specify trans-isomer content are unmeasurable in practice. Cis-resveratrol is biologically inactive.
QuercetinPlain quercetin dihydrate has poor absorption. Phytosome forms deliver 10 to 20× more into blood.
PterostilbeneHigh-dose pterostilbene can raise LDL. Keep to <150 mg/day unless working with a clinician.

Editorial notes

Trusted budget brand; doses below Sinclair-protocol level.

Go deeper

Where this sits

Actives inside
ResveratrolQuercetinPterostilbene
Category
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