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Daily Ultimate Longevity

Longevity stack · Powder sachet · 30 servings

Label snapshot

What the label says

What the product contains and what one serving costs, according to our catalog. Label amounts are not personal dose recommendations.

Ingredients listed
9 ingredients listed largest listed: Glycine 3,000 mg
Form
Powder sachet
List price (catalog, USD)
$149.00
Price per serving
$4.97List price divided by servings per container. A per-day cost only if the label serving is once daily.

Reading notes

  • Multi-ingredient product. Amounts are per ingredient per serving; the product is assessed as one bundle, not as a recommendation for each ingredient.
Full label record: servings, testing, ingredients
Servings per container
30
Serving size (label)
6.4 g
Catalog monthly estimate
$149.00
Testing disclosure
Brand lists third-party testing; no public lab certificate listedStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Ingredients as listed

IngredientAmount per serving
Glycine3,000 mg
Taurine2,000 mg
NMN300 mg
Resveratrol250 mg
Quercetin250 mg
Fisetin100 mg
PQQ10 mg
Astaxanthin6 mg
Spermidine3 mg

What to check on the label

  • Whether every ingredient has its own milligram line, or several are grouped in a 'blend' with one total.
  • How many capsules or scoops make a serving, and how many servings the container holds.
  • Whether the ingredients you care about appear at amounts you would accept on their own. The list below shows each figure.

Amounts are per label serving as recorded in the catalog and are not a recommendation. Testing status reflects what the brand lists. Nothing here is medical advice.

Editorial score and research-dose calculations

These calculations describe our scoring method. They are not a recommended dose or proof of benefit from this product.

5.5/10
Overall score
#12 / 16 in Longevity stack

Tested by independent lab.

Read the evidence (3 studies)
Watch outEU restricted2 ingredients restricted in the EU
  • NMN — Unauthorised Novel Food; EFSA positive safety opinion adopted 4 March 2026 at up to 300 mg/day (β-NMN, EffePharm dossier). Commission listing pending.
  • Spermidine — Novel Food status for concentrates >7 mg; wheat-germ traditional food
You can legally buy these outside the EU. Sale as a food supplement inside the EU requires a Novel Food authorisation these ingredients do not have.
Tier 3
Ingredient RCT (matching dose)
The ingredient was tested in an RCT at the same dose this product sells.
See the 3 supporting studies
How we scored this product Show the full breakdown
Composite How this 5.5 is built. 0.50 × 6.5 + 0.20 × 7.0 + 0.10 × 3.0 + 0.10 × 5.0 + 0.05 × 7.0 + 0.05 × 9.2 = 5.5 out of 10. Safety caps applied after. 5.5
5.5 composite
Dose vs. studies50%6.5
Transparency20%7.0
Value10%3.0
Formulation10%5.0
Safety5%7.0
Community5%9.2

Evidence gates dose: the evidence grade sets the ceiling, and the dose decides how much of that ceiling the product reaches. Value = inverse of price-per-trial-dose-day. Community = mean sentiment of external reviews. Safety caps applied after weighting.

This score is our editorial judgment, not a scientific standard. We combine published evidence, dose, price, transparency, and consumer signals into one composite: this is our method, not a peer-reviewed clinical rating. A higher score means a product does better on the factors we weight, not that it is medically proven to work.

Read the full method →

Editorial verdict

Quick verdict

5.5 / 10
Best for
Full trial dose
Avoid if
No public lab certificate, Premium pricing
Full-dose status
Meets trial dose
Price/month
$149
COA status
Not public
Biggest caveat
Fisetin (100mg is 20% of the 500mg trial dose) is significantly under-dosed.
Nearest alternatives
Catalog snapshot. Check linked sources for current price, label and batch-specific testing.
Price verification
Current price: $149.00
Last price check: Sep 01, 2026
Layer 2 · Context

Our summary

Daily Ultimate Longevity is the more defensible of IM8's two products because every one of its ten active ingredients has a specific, publicly stated milligram dose and a real, if uneven, evidence base behind it. Two doses are genuine standouts: NMN at 300 mg matches (and slightly exceeds) the widely cited Yoshino 2021 human trial dose, and astaxanthin at 6 mg sits right at the low end of doses shown to help skin and eye health. Glycine (3,000 mg) also exactly matches a well-known sleep-quality study. But several other ingredients fall well short of the doses used in the research IM8's marketing implicitly leans on: PQQ delivers half the classic 20 mg cognitive-trial dose, fisetin delivers roughly one-fourteenth of the pulsed senolytic dose used in Mayo Clinic trials, and quercetin sits at half the dose used in most positive metabolic trials. Compared with single-ingredient specialist brands such as DoNotAge, IM8 typically delivers only about a quarter to two-fifths of the dose for the same shared ingredients (NMN 300 mg vs. 1,000 mg = 30%; spermidine 3 mg vs. 8 mg = 37.5%) at a similar or higher daily price — so the product functions less as ten separately 'clinically proven' doses and more as a broad, moderate-strength longevity sampler.
In plain language

Why this scored this way

This IM8 Daily Ultimate Longevity scores 6.3, making it below the site average. It delivers 3000mg of Glycine, inside the studied range of 1000–10000mg with grade B evidence (promising human data, not yet comprehensive). At $4.97/day it's among the more expensive options in Longevity stack.

What drives the score up

  • Dose-evidence score of 6.5 shows decent alignment with trial doses.
  • Tested by independent lab (transparency 7.0).
  • Community score of 9.2 with positive consumer feedback.
  • Glycine is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).
  • NMN is dosed at the full research level with grade B evidence (promising human data, not yet comprehensive).

What drags it down

  • Fisetin (100mg is 20% of the 500mg trial dose) is significantly under-dosed.
  • Spermidine (3mg is 250% of the 1.2mg trial dose) is well above the trial dose. More is not always better.
  • No public lab certificate available for independent verification.
  • At $4.97/day it's on the expensive side.

Why you'd choose it

  • You want Glycine from a IM8 product.
  • You want a tested by independent lab product.

Why you might skip it

  • You want a product with a publicly available CoA.
  • You need a full trial dose of fisetin (this product under-doses it).
  • You want a standard dose of spermidine (this product is well above it).
Question 1

Does the molecule work?

The science behind each active ingredient, independent of which brand sells it.

Glycine

Cheap amino acid with better sleep and glutathione-precursor benefits.

1 landmark RCT · US: Dietary supplement / GRAS · EU: Food supplement
Taurine

The 2023 sensation; species-wide lifespan extension in mice, humans unproven.

2 landmark RCTs · US: Dietary supplement · EU: Food supplement
NMN

A NAD+ building block that has become the most-hyped longevity molecule.

5 landmark RCTs · US: FDA reversed exclusion 29 September 2025; NDIN 1247 and NDIN 1259 reinstated 2 December 2025; NDIN 1444 (β-NMN, Effepharm) response 28 January 2026. NMN is a dietary ingredient again; each marketer still needs NDIN coverage. · EU: Unauthorised Novel Food; EFSA positive safety opinion adopted 4 March 2026 at up to 300 mg/day (β-NMN, EffePharm dossier). Commission listing pending.
Resveratrol

The famous red-wine molecule; longevity claims have outrun the human evidence.

3 landmark RCTs · US: Dietary supplement · EU: Authorised Novel Food (2016/1866)
Quercetin

Best-studied 'senolytic' ingredient, though evidence is early.

4 landmark RCTs · US: Dietary supplement · EU: Food supplement (extract-dependent)
Fisetin

Highly-hyped senolytic; the strong evidence is in mice, not people.

3 landmark RCTs · US: Dietary supplement · EU: Food supplement
PQQ

Promising cofactor for mitochondrial biogenesis; human evidence remains thin.

1 landmark RCT · US: Dietary supplement · EU: Novel Food authorised
Astaxanthin

The 'sunscreen from within' with real skin, eye, and endurance data.

1 landmark RCT · US: Dietary supplement · EU: Food supplement (max 8 mg/day per EFSA)
Spermidine

The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.

2 landmark RCTs · US: Dietary supplement · EU: Novel Food status for concentrates >7 mg; wheat-germ traditional food

Full ingredient breakdown

Every active in this formula, its declared dose per serving, the dose used in the primary human trial, how much of that trial dose this product delivers, and the evidence grade for the ingredient itself.

IngredientDose / servingResearch dose% of researchEvidence grade
Glycine3000 mg3000 mg100%B
Taurine2000 mg3000 mg67%D
NMN300 mg500 mg60%B
Resveratrol250 mg500 mg50%C
Quercetin250 mg500 mg50%B
Fisetin100 mg500 mg20%C
PQQ10 mg20 mg50%C
Astaxanthin6 mg8 mg75%B
Spermidine3 mg1.2 mg250%C

Percentages are dose per serving ÷ primary trial dose. Below 50% means the formula is unlikely to reproduce the trial outcome for that active. Grade A = multiple large human RCTs. Grade F = no human evidence. How grades work. Full glossary →

Question 2

Is this bottle good?

The specific product: dose, price, transparency, and what buyers report.

Dose vs research
100% of trial dose
Meets or exceeds the published effective dose
Cost at trial dose
$4.97/day at trial dose
What one effective daily dose actually costs
Transparency
7.0/10 · No public lab certificate
Independent batch testing confirmed
Consumer signals
952 reviews across platforms · 4.6/5 · medium confidence
Operational signal only, never used as clinical evidence
Question 3

What's the catch?

Safety flags, transparency gaps, dosing concerns, and recurring buyer complaints.

Safety signals
Drug interaction risk — glycine
May reduce the efficacy of clozapine.
Read more
Drug interaction risk — resveratrol
Inhibits CYP3A4, CYP2C9, and CYP2D6 at doses ≥1,000 mg/day (activates CYP1A2). Interacts with warfarin (increased anticoagulant effect), tamoxifen, statins (myopathy risk), tacrolimus, and NSAIDs/antiplatelets (bleeding risk).
Read more
Safety flag
resveratrol: CYP3A4 interactions; fisetin: warfarin/anticoagulant interaction
Dose or interaction risk detected. See ingredient page for details.
No public lab certificate
Certificate of Analysis not published
Without a public lab certificate, batch purity and potency cannot be independently verified.
Plain English

What’s inside

The main ingredients of this product, in plain language.

Glycine3000 mgEvidence B

Cheap amino acid with better sleep and glutathione-precursor benefits.

Read about Glycine →
Taurine2000 mgEvidence D

The 2023 sensation; species-wide lifespan extension in mice, humans unproven.

Read about Taurine →
NMN300 mgEvidence B

A NAD+ building block that has become the most-hyped longevity molecule.

Read about NMN →
Resveratrol250 mgEvidence C

The famous red-wine molecule; longevity claims have outrun the human evidence.

Read about Resveratrol →
Layer 3 · Evidence vault

Product data & verification

Hard numbers and independently checked status. Expand each block for its source.

The numbers

Price
$149
per bottle · 30 servings
Dose vs. research
of trial dose 100%
of published effective dose
$ / day at studied dose
$4.97
what one effective daily dose costs
$ / g active
$0.84
per gram of active substance
Independently checked

Data verification

COA status
Not public
Evidence grade
BDBCBCCBC
Per-ingredient breakdown
BGlycine
DTaurine
BNMN
CResveratrol
BQuercetin
CFisetin
CPQQ
BAstaxanthin
CSpermidine

All product data is checked against original sources. Prices, doses, and testing status are updated when product pages change. Evidence grades are reviewed when new human RCTs are published. Read how we verify.

What's inside

Ingredient
Dose in this product
Trial dose
Evidence
Glycine
Cheap amino acid with better sleep and glutathione-precursor benefits.
3000 mg 100% of trial dose
3000 mg
Taurine
The 2023 sensation; species-wide lifespan extension in mice, humans unproven.
2000 mg 67% of trial dose
3000 mg
NMN
A NAD+ building block that has become the most-hyped longevity molecule.
300 mg 60% of trial dose
500 mg
Resveratrol
The famous red-wine molecule; longevity claims have outrun the human evidence.
250 mg 50% of trial dose
500 mg
250 mg 50% of trial dose
500 mg
100 mg 20% of trial dose
500 mg
PQQ
Promising cofactor for mitochondrial biogenesis; human evidence remains thin.
10 mg 50% of trial dose
20 mg
Astaxanthin
The 'sunscreen from within' with real skin, eye, and endurance data.
6 mg 75% of trial dose
8 mg
Spermidine
The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.
3 mg 250% of trial dose
1.2 mg
4.6 /5
Medium confidence Strong value signal
952 reviews across 2 platforms (2 sources)
Source diversity: 46%
Review aggregatorTrustpilot
Last checked: 2026-08-20

Consumer signals

4.6 out of 5 across 952 verified reviews on 2 platforms.

Medium confidence

Auto-gathered from public review platforms via pplx_sdk fetch.

952 reviews · 4.6/5 · positive sentiment

These are consumer sentiment signals. They do not measure whether the product actually works. See our evidence section for that.

What others say, with a source hierarchy

We treat external opinion very differently depending on where it comes from. Tier A is our strongest signal. Tier C is background sentiment only. Tier Rejected is what we excluded, listed openly so you can see what we discarded.

These reviews are aggregated from third-party sources, not written by NO1GEVITY. Each entry shows its source, retrieval date, and whether the source has an affiliate or paid relationship. We do not edit reviews to change their meaning. Disclosure policy.

Tier A

Independent deep reviews, lab tests, certificates of analysis

Our strongest external evidence. Long-form independent reviews, physical-product lab work, and third-party certifications.

Innerbody Research
No affiliate relationship Not a paid placement
Independent long-form review team (~100 h per brand).

Well-formulated: most ingredients delivered at clinically relevant doses (glycine 3000 mg, taurine 2000 mg, NMN 300 mg, fisetin 100 mg).

How we use it: Primary Tier A source for the Longevity SKU. Ingredient/dose facts adopted.
El País — investigation of David Beckham's IM8 supplements
No affiliate relationship Not a paid placement
Major Spanish daily; expert commentary named on record.

A physiologist at Universidad Rey Juan Carlos argues IM8's 'kitchen sink' strategy violates the basic supplement principle of 'only take what you need'. El País also notes IM8 stopped shipping to Spanish customers shortly after the paper contacted the company.

How we use it: Primary independent-press critique cited on IM8 brand and product pages.
Daily Mail — expert verdict on Beckham 'glow up' supplement
No affiliate relationship Not a paid placement

Named experts describe the Beckham-branded supplements as 'meaningless nonsense' for failing to disclose per-ingredient doses.

How we use it: Secondary press critique — supports El País finding on dose disclosure.
Tier B

Registered dietitians and physicians, without affiliate ties

Credentialed commentary from clinicians who disclose no paid relationship. Useful as supporting critique but not a substitute for a clinical outcome trial.

Registered dietitian — IM8 Daily Essentials review (non-sponsored)
No affiliate relationship Not a paid placement
Registered dietitian; explicit non-sponsored disclosure.

Independent dietitian walks through the label; flags underdosing on several actives and questions the value of blends without listed amounts.

How we use it: Supporting Tier B critique of dose realism.
UK fitness teardown — IM8 amino-acid blend
No affiliate relationship Not a paid placement
UK fitness coach; independent teardown; no affiliate.

Adds up IM8's amino-acid blend: 1.58 g total. Muscle protein synthesis normally needs ≥2-3 g of leucine alone, so the blend cannot plausibly drive the outcomes it is marketed toward.

Finding: Amino-acid blend totals 1.58 g per serving.
How we use it: Standout Tier B dose-realism critique cited on the Essentials/blend page.
Tier C

Aggregated sentiment (Trustpilot, Reddit)

Mood indicator only. We never use aggregate stars as evidence of efficacy.

Trustpilot — IM8 (aggregated sentiment)
No affiliate relationship Not a paid placement

Aggregate score ≈ 4.5-4.6 / 5. Mood indicator only.

Finding: 4.5-4.6 / 5.
How we use it: Sentiment only. Never used as evidence of efficacy.
Rejected

Sources we transparently discard

Marketing-quoted press, obviously fabricated aggregate ratings, or heavy-affiliate 'reviews'. Listed openly so you can see what we excluded.

Forbes coverage — reused as marketing by IM8 and NOVOS
unknown Not a paid placement

Business journalism, not product testing. IM8 and NOVOS both quote Forbes on their own marketing pages.

How we use it: Not used as evidence. Flagged so readers see why 'as seen in Forbes' does not equal an independent efficacy review.
'Scam or legit' aggregator — beautyhealthfitnessremedies.com
Has affiliate relationship Not a paid placement

Fabricated-looking average ratings and heavy affiliate links. Not usable as evidence at any tier.

How we use it: Rejected from the source set.
Layer 3 · Evidence vault

Evidence, claims & regulation

Published evidence, claim checks, regulatory status and what could not be verified.

Evidence, what actually backs this product

Longevity brands rarely test their exact finished product. We separate what's tested from what's inferred.

Strongest evidence tier
Tier 3Ingredient RCT (matching dose)
9 studies mapped
Tier 3Ingredient RCT (matching dose)
The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers
Bannai M, Kawai N, Ono K, Nakahara K, Murakami N · 2012 · Frontiers in Neurology · n=11 · 3,000 mg glycine before bed · Short-term (single/repeated night protocol)
3 g glycine before bedtime improved subjective sleep quality and reduced daytime sleepiness/fatigue versus placebo.
IM8's 3,000 mg glycine dose matches this trial's dose exactly — one of the clearest dose-to-evidence matches in the product.
Tier 3Ingredient RCT (matching dose)
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Yoshino M, Yoshino J, Kayser BD, et al. · 2021 · Science · n=25 · 250 mg NMN/day · 10 weeks
NMN supplementation improved muscle insulin sensitivity, though the study did not detect a measurable rise in whole-body NAD+ levels, and gains did not extend to blood-sugar control or body composition.
IM8's 300 mg NMN dose meets and modestly exceeds this landmark trial's 250 mg dose — flagged as a positive dose-match, though the trial itself showed a narrower benefit (insulin sensitivity only) than IM8's broader NAD+/energy marketing implies.
Tier 3Ingredient RCT (matching dose)
Astaxanthin supplementation for skin and antioxidant outcomes
Various (systematic review/meta-analysis synthesis) · 2021 · Various (e.g., PMC8472736 meta-analysis) · 4-12 mg/day, most commonly 6 mg for skin/eye endpoints · 8-12 weeks typical
Oral astaxanthin in the 4-6 mg range measurably improved skin moisture and elasticity in meta-analyzed RCTs.
IM8's 6 mg astaxanthin dose is a genuine, verified dose match to the skin/eye-health literature — one of the strongest ingredient-level claims in this product.
Tier 4Ingredient RCT (different dose)
Taurine deficiency as a driver of aging
Singh P, Gollapalli K, Mangiola S, et al. · 2023 · Science · Varied by species; not a fixed human clinical dose · Lifespan study (mice), multi-year (monkeys)
Taurine supplementation extended median mouse lifespan by 10-12% and improved several aging biomarkers in monkeys; human data in this paper were purely observational (declining blood taurine with age), not an interventional trial.
The NIH's Intramural Research Program subsequently published data questioning whether declining taurine is a reliable human aging biomarker, adding uncertainty to the narrative IM8 cites for taurine's inclusion.
Tier 4Ingredient RCT (different dose)
Effect of the antioxidant supplement pyrroloquinoline quinone disodium salt (BioPQQ) on cognitive functions
Nakano M, Yamamoto T, Okamura H, Tsuda A, Kowatari Y (and related Nakano PQQ trials) · 2012 · Advances in Experimental Medicine and Biology / Functional Foods in Health and Disease · n=41 · 20 mg PQQ/day · 8-12 weeks
20 mg/day PQQ improved measures of cognitive function, working memory, and reduced markers of oxidative stress and fatigue versus placebo.
IM8 delivers 10 mg — half the dose used in the classic PQQ cognitive trials — so this ingredient falls short of a dose match despite IM8's marketing framing it as within 'the proven dosage range.'
Tier 4Ingredient RCT (different dose)
Quercetin as a therapeutic product: evaluation of its anti-inflammatory and antioxidant effects
Various · 2022 · Various (e.g., PMC10674654 synthesis) · n=72 · 500 mg quercetin/day · 10 weeks
500 mg/day quercetin significantly reduced inflammatory markers (TNF-alpha, IL-6) and improved lipid and blood-pressure measures versus placebo.
IM8's 250 mg dose is half the dose used in this and several other positive quercetin trials, and a quarter of the 1,000 mg used in Dasatinib+Quercetin senolytic pilots.
Tier 4Ingredient RCT (different dose)
Absorption kinetics of berberine and dihydroberberine and their impact on glycemia
Pekarek T, et al. (bioavailability study underlying GlucoVantage / dihydroberberine ingredient dossiers) · 2022 · Various nutraceutical PK literature (PMC8746601 / PubMed 35010998) · 100-200 mg dihydroberberine vs. 500 mg standard berberine · Single-dose pharmacokinetic comparison
100-200 mg dihydroberberine produced higher plasma berberine exposure and comparable or better glycemic effects than a 500 mg dose of standard berberine, supporting manufacturer claims of markedly improved bioavailability for the dihydro form.
IM8's bioavailability claim for its 100 mg dihydroberberine is reasonably well supported by this specific comparison, though it is a single study largely tied to the ingredient's supplier rather than a broad independent literature base — we still class this Tier 4 given limited independent replication.
Tier 4Ingredient RCT (different dose)
Effects of spermidine-rich rice germ extract supplement on biomarkers of aging
Various · 2025 · Not fully specified in source (PubMed indexed) · 1.5 mg or 3.3 mg spermidine/day · Not specified in available snippet; multi-week
The trial explicitly tested 1.5 mg and 3.3 mg spermidine doses and noted that human research demonstrating a specific dose capable of increasing autophagy biomarkers is still lacking, i.e., even the higher of these two tested doses has not been conclusively shown to move biomarkers.
IM8's 3 mg spermidine dose sits almost exactly between the two doses tested here, and below the 8 mg used by single-ingredient competitors like DoNotAge — the evidence base for any specific spermidine dose in humans remains thin regardless of brand.
Tier 5Mechanistic / animal / marketing
Fisetin senolytic dosing in Mayo Clinic and related trials
Various (e.g., NCT03675724, NCT04313634) · 2023 · ClinicalTrials.gov listings / Nutrients review · n=40 · 20 mg/kg/day for 2 consecutive days per cycle (~1,400 mg for a 70 kg adult) in intermittent senolytic protocols · 2-day pulsed dosing per month, over several months
Intermittent, high-dose fisetin pulses are the protocol associated with the senolytic (senescent-cell-clearing) mechanism fisetin is best known for.
IM8's 100 mg/day continuous dose is roughly 14x lower than the senolytic pulse dose and follows a completely different (daily vs. pulsed) protocol, so the senolytic framing used in IM8's marketing is not directly supported by the trials it implicitly references.

Claim check, vendor claims vs. our reading of the evidence

Not medical advice. We list the strongest claims made by the brand and check each against traceable evidence.

Partial support
“"Every ingredient in IM8 Longevity is dosed based on published human clinical trials—not marketing convenience. We use therapeutic doses proven effective in peer-reviewed research."”
This holds up well for three ingredients (NMN, glycine, astaxanthin), which do match or approach specific human RCT doses. It does not hold up for PQQ (half the classic trial dose), fisetin (roughly 1/14th of the Mayo senolytic pulse dose and a different daily-vs-pulsed protocol), or quercetin (half the dose used in most positive trials). The blanket claim that 'every ingredient' meets peer-reviewed therapeutic doses overstates what the underlying research supports for at least three of the ten actives.
Not supported
“"3 mg spermidine, the clinically recommended daily dose for individuals"”
There is no single agreed 'clinically recommended' spermidine dose in the literature; trials have tested doses from about 1.2 mg to 8 mg/day with mixed results, and a 2025 rice-germ RCT tested exactly 1.5 mg and 3.3 mg without conclusively establishing either as an effective threshold for autophagy biomarkers. Describing 3 mg as *the* clinically recommended dose implies a consensus that does not exist.
Supported, at a lower dose than this product
“"300 mg pharmaceutical-grade NMN... the same combination and dosage range proven in multiple clinical trials to elevate NAD+ levels"”
300 mg NMN does match or slightly exceed the 250 mg dose used in the best-known human RCT (Yoshino et al. 2021), so this specific claim is reasonably well supported for that trial — though that same trial did not detect a measurable rise in whole-body NAD+ levels despite the metabolic benefit it did find, so the 'elevate NAD+ levels' framing overstates what was actually shown in the human study IM8 is implicitly relying on.
Partial support
“Dihydroberberine offers 'five times the bioavailability of standard berberine'”
A published pharmacokinetic comparison found 100-200 mg dihydroberberine produced meaningfully higher plasma exposure than a 500 mg standard berberine dose, broadly consistent with a substantial bioavailability edge — but the precise '5x' figure traces to industry/ingredient-supplier materials rather than a large independent literature base, so we treat the direction of the claim as credible and the specific multiplier as not independently confirmed.
Supported
“Dose comparison vs. single-ingredient specialist brand DoNotAge for shared actives”
Checking IM8's label against DoNotAge's published label doses: NMN 300 mg vs. DoNotAge's 500-1,000 mg (30-60%), trans-resveratrol 250 mg vs. DoNotAge's 500-1,000 mg (25-50%), quercetin 250 mg vs. DoNotAge's 400-800 mg (31-62%), and spermidine 3 mg vs. DoNotAge's 8 mg (37.5%). Across these four shared ingredients IM8 consistently delivers roughly a quarter to two-thirds of DoNotAge's dose, at a broadly comparable or higher daily price once IM8's typical subscription discount is applied — this is the central, verifiable finding behind the 'you get less of each active ingredient for a similar price' critique of IM8's longevity formula.
internal analysis

Regulatory status

Rules change often. We record when we last verified each row. See the full regulatory timeline →

US
Legal as supplement
NMN's regulatory status in the US had been contested — the FDA excluded NMN from the dietary supplement definition in November 2022 under the drug-preclusion clause, but reversed that position in a letter dated September 29, 2025, confirming NMN is not excluded and can proceed through the New Dietary Ingredient pathway. IM8 has continued selling Longevity with NMN throughout this period.
Last verified 2026-08-05
EU
Novel Food, not cleared
NMN remains an unauthorized EU Novel Food as of our review; the European Food Safety Authority issued a positive safety opinion in May 2026 on a 300 mg/day intake of one supplier's NMN (EffePharm), which is a step toward eventual authorization but is not the same as a finalized EU-wide approval, and it does not specifically cover IM8's NMN source.
Last verified 2026-08-05
UK
Legal
Post-Brexit UK novel food rules diverge from the EU; NMN supplements are broadly sold in the UK market without the same novel-food blocker.
Last verified 2026-08-05
CA
Restricted But Available As Licensed Form
Health Canada has permitted NMN as an ingredient in licensed Natural Health Products (e.g., NPN 80115992) with a monograph limit of up to 1,200 mg/day and 600 mg per single dose — meaning NMN itself is not banned in Canada, but we did not confirm that IM8's specific Longevity SKU carries its own NPN license.
Last verified 2026-08-05

What we could not verify

We list this openly. If a claim isn't backed by a source we can trace, we'd rather flag it than repeat it.

  • IM8's claim that Longevity is 'the first supplement scientifically formulated to comprehensively target all 12 hallmarks of aging' — this is a marketing framing tied loosely to the real López-Otín et al. 2023 Cell paper on hallmarks of aging, but we could not verify any independent scientific body has validated that this specific ingredient list addresses all twelve hallmarks as claimed.
  • Whether IM8's NMN, PQQ, or dihydroberberine sources carry independent purity certificates beyond the general NSF Certified for Sport program-level report.
  • The exact current retail price at any given moment, given multiple, apparently shifting promotional price points found across 2025-2026 sources ($89-$149 one-time; $75-$119/month).
Important to know
GlycineNone major. Very sweet in powder form, mix in water or coffee.
TaurineVery cheap in powder form; capsules charge a premium for the same molecule.
NMNAbsorption varies wildly by form. Sublingual and liposomal claim better uptake but human head-to-head data is limited.
Resveratrol"Resveratrol" products that don't specify trans-isomer content are unmeasurable in practice. Cis-resveratrol is biologically inactive.
QuercetinPlain quercetin dihydrate has poor absorption. Phytosome forms deliver 10 to 20× more into blood.
FisetinStandard capsules have <5% absorption. Look for liposomal or with piperine.
PQQPQQ is very expensive to synthesise, so cheap products may under-deliver. Look for third-party COA.
AstaxanthinSynthetic astaxanthin (from petrochemicals) is not the same stereoisomer as natural. Insist on Haematococcus source.
SpermidineProduct labels often say 'wheat germ extract 800 mg', that could be 0.8 mg or 8 mg of actual spermidine. Insist on labeled spermidine content.

Editorial notes

Ten longevity actives at moderate doses. NMN 300mg is 30-60% of the DoNotAge dose.

Brand owners

Spot an error?

If you are the manufacturer or brand owner of Daily Ultimate Longevity and believe any data on this page is incorrect (wrong dose, wrong ingredient, wrong price, missing certification, outdated status), you can request a correction.

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Same shelf

Similar products

All Longevity stack →

The next highest-scoring products in Longevity stack, same scoring method, same rules.

AG1 (Athletic Greens)
Longevity stack
Ingredients listed
2 ingredients listedlargest listed: Vitamin K2 100 µg
Price per serving
$0.05$29.00 · 600 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 7.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.10
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with drinkag1.com
Elysium Health
Longevity stack
Ingredients listed
2 ingredients listedlargest listed: NR 250 mg
Price per serving
$2.00$60.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$2.40
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.elysiumhealth.com
Longevity stack
Ingredients listed
6 ingredients listedlargest listed: Creatine 2,500 mg
Price per serving
$1.63$49.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

83%
of trial dose
$3.27
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with blueprint.bryanjohnson.com
Same maker

Other products from IM8

Brand profile →
Longevity stack
Ingredients listed
8 ingredients listedlargest listed: Creatine 3,000 mg
Price per serving
$4.30$129.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

50%
of trial dose
$17.20
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with im8health.com