A methyl donor added to NAD+ formulas as a supporting cofactor, not a headline active.
Real ingredient with real evidence, but only at doses much higher than what's typically included in NAD+ combination capsules. Treat small doses in blends as a minor add-on, not a therapeutic dose.
Betaine (TMG) (Betaine Anhydrous (Trimethylglycine)) is a methylation support with evidence grade C, meaning it is backed by mixed or small human trials. We track 16 products containing Betaine (TMG). Typical doses range from 25 to 2000 mg per serving. The top-ranked product scores 7.7 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $105.00 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| NiaCel 400 | Thorne HealthTech | 25 mg | $65.00 | Yes | 7.7 |
| Nicotinamide Riboside Pro 300 + 100mg TMG | ProHealth Longevity | 100 mg | $24.95 | Yes | 7.5 |
| ResveraCel | Thorne HealthTech | 150 mg | $105.00 | Yes | 7.0 |
| NiaCel 200 | Thorne HealthTech | 42.5 mg | $29.00 | Yes | 7.0 |
| NAD+ Support | Innerbody Labs | 500 mg | $74.00 | Yes | 6.9 |
Scores are editorial judgments, not a scientific standard. See how we score.
Betaine (also called trimethylglycine, or TMG) is a small molecule found naturally in beets and other foods. It donates a methyl group to help convert homocysteine back into methionine.
At gram-level doses (1.5-6 g/day) betaine has decent human evidence for lowering homocysteine and some liver-fat markers. The 25-150 mg doses typically added to NAD+ combination products are far below those studied amounts and mainly function as a formulation cofactor rather than a dosed active ingredient.
Real ingredient with real evidence, but only at doses much higher than what's typically included in NAD+ combination capsules. Treat small doses in blends as a minor add-on, not a therapeutic dose.
Trimethylglycine (TMG); methyl donor in the betaine-homocysteine methyltransferase (BHMT) pathway.
Clinical trials on homocysteine reduction and non-alcoholic fatty liver disease use 1.5-6 g/day; doses under 200 mg/day have little independent human outcome data.
Hours; renally cleared.
Doses under roughly 500 mg/day (as seen in most NAD+ combination products) are well below the gram-level doses used in the supporting human trials.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for Betaine (TMG), most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
All products in our catalog that contain Betaine (TMG), ranked by our overall score. Ranking is editorial, never paid.
Thorne HealthTechStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ProHealth LongevityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Thorne HealthTechMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Thorne HealthTechStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Innerbody LabsMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ProHealth LongevityMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
DoNotAgeStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
CodeageMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
CodeageMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ProHealth LongevityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
MomentousMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Double Wood SupplementsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
BulkSupplementsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Perpetua LifeMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Quicksilver ScientificStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside Betaine (TMG) in our catalogue.
See Betaine (TMG) in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View Betaine (TMG) on the Longevity Map →Betaine (also called trimethylglycine, or TMG) is a small molecule found naturally in beets and other foods. It donates a methyl group to help convert homocysteine back into methionine.
The trial dose in published human studies is 3000 mg per day, with a range of 1500 to 6000 mg per day. Always consult a qualified clinician before starting any supplement.
Doses under roughly 500 mg/day (as seen in most NAD+ combination products) are well below the gram-level doses used in the supporting human trials.
We track 16 products containing Betaine (TMG). The top-ranked product scores 7.7 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
Betaine (TMG) has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.