A NAD+ building block that has become the most-hyped longevity molecule.
The biology is real. The evidence for actual longevity or muscle/cognitive benefits in humans is thinner than the marketing suggests. Well-studied for safety at 250 to 2000 mg/day; efficacy band 250 to 900 mg/day.
NMN (Nicotinamide Mononucleotide) is a NAD+ precursor with evidence grade B, meaning it is supported by human RCTs. We track 39 products containing NMN. Typical doses range from 250 to 1000 mg per serving. The top-ranked product scores 8.3 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $98.95 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| NMN Pure Powder (Sublingual) | Renue By Science | 500 mg | $64.95 | Yes | 8.3 |
| Pure NMN | DoNotAge | 1000 mg | $65.00 | Yes | 8.1 |
| Nicotinamide Mononucleotide (NMN) Capsules | NAD+ Precursor | Nootropics Depot | 250 mg | $49.99 | Yes | 8.1 |
| NMN Pro 1000 | ProHealth Longevity | 1000 mg | $79.00 | Yes | 8.0 |
| NMN Pro™ Powder - Uthever® NMN | ProHealth Longevity | 1000 mg | $98.95 | Yes | 7.9 |
Scores are editorial judgments, not a scientific standard. See how we score.
Your cells run on a molecule called NAD+. It powers energy production and DNA repair. NAD+ drops as we age. NMN is a compound your body converts into NAD+.
The theory: if you replenish NAD+, cells work more like they did when you were younger. Blood NAD+ does go up when you take NMN. Whether that translates to living longer or healthier is still an open question.
The biology is real. The evidence for actual longevity or muscle/cognitive benefits in humans is thinner than the marketing suggests. Well-studied for safety at 250 to 2000 mg/day; efficacy band 250 to 900 mg/day.
β-Nicotinamide Mononucleotide (β-NMN). Intermediate in the NAD+ salvage pathway, one enzymatic step from NAD+ via NMNAT.
Human RCTs (Yoshino 2021; Yi 2023; Liao 2021) confirm dose-dependent increases in blood NAD+ and PBMC NAD+. Efficacy signals appear from 250 to 300 mg upward, strengthen to about 600 mg, and flatten between 600 and 900 mg with no demonstrated clinical advantage above 900 mg (Yi 2023 head-to-head; Zhang 2026 meta-analysis dose subgroup p=0.9344). Endpoint benefits (VO2max, aerobic capacity, gait speed, insulin sensitivity) reported in some trials but effect sizes small and populations narrow.
Rapid oral absorption; NAD+ half-life in tissue 5 to 7 hours.
Absorption varies wildly by form. Sublingual and liposomal claim better uptake but human head-to-head data is limited.
When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for NMN, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
Consumer reports submitted to an official government adverse-event database. These reports mention this ingredient but do not prove it caused the reaction. Report volume reflects market penetration as much as inherent risk.
Retrieved from the FDA Adverse Event Reporting System (CAERS) via the openFDA API. Verified 2026-08-06. Reports are voluntary consumer submissions and mandatory serious-event filings. They establish surveillance, not causality.
Verified 2026-08-06. We update this section as new peer-reviewed trials land.
NMN reliably raises blood NAD+ levels in humans. A 2024 meta-analysis of 12 RCTs (513 participants) by Jiaqi Zhang and colleagues confirmed a significant rise in blood NAD after supplementation (https://pubmed.ncbi.nlm.nih.gov/39116016/). A separate 2024 meta-analysis of 9 studies (412 participants) by Jian-Peng Wang and colleagues found NMN improved gait speed (SMD 0.34 m/s, p=0.033) and lowered ALT in middle-aged and elderly adults (https://pubmed.ncbi.nlm.nih.gov/39185644/). These are the two strongest signals in the human data.
Marketers describe NMN as a reversal agent for aging, promising restored energy, sharper cognition, and extended lifespan. Human RCTs do not support this. Zhang's 2024 meta-analysis found most clinically relevant outcomes, including fasting glucose, triglycerides, and cholesterol, showed no significant difference from placebo (https://pubmed.ncbi.nlm.nih.gov/39116016/). A 2025 review by Aisyah Kuerec and colleagues on muscle mass and function in adults over 60 found NMN and NR gave no significant improvement in skeletal muscle index, grip strength, knee extension, or short physical performance battery scores (https://pmc.ncbi.nlm.nih.gov/articles/PMC12022230/). No human trial has measured lifespan extension.
250-900 mg once daily, with trial doses ranging from 250 mg to 2000 mg per day
NMN is well tolerated across trial doses of 250-2000 mg/day for up to 24 weeks. A 2026 meta-analysis of 15 RCTs found no increase in overall adverse events, serious adverse events, or liver enzyme elevations (ALT/AST) versus placebo (https://pubmed.ncbi.nlm.nih.gov/42514320/). Long-term safety beyond 6 months has not been tested in humans. NMN is not FDA-approved as a dietary ingredient in the US and its legal status has shifted amid ongoing FDA review.
In an 80-person, 60-day dose-dependent RCT, oral NMN (up to 900 mg/day) significantly raised blood NAD+ levels, was safe and well-tolerated, and improved six-minute walking distance versus placebo.
Read study →A 30-person, 12-week RCT found 250 mg/day oral NMN significantly increased whole-blood NAD+ levels with no adverse effects.
Read study →In 66 adults aged 40-65 over 60 days, NMN (300 mg/day) increased serum NAD+/NADH by 38% versus baseline and improved SF-36 quality-of-life scores compared to placebo.
Read study →A meta-analysis of 12 RCTs (513 participants) found NMN reliably raises blood NAD+ but shows no significant effect on most glucose or lipid outcomes, suggesting metabolic benefits may be overstated.
Read study →A meta-analysis of 10 RCTs (349 participants) found NMN supplementation significantly reduced both systolic and diastolic blood pressure in adults with elevated blood pressure, with the effect most pronounced in hypertensive subgroups.
Read study →All products in our catalog that contain NMN, ranked by our overall score. Ranking is editorial, never paid.
Renue By ScienceStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
DoNotAgeStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Nootropics DepotStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ProHealth LongevityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ProHealth LongevityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Double Wood SupplementsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Renue By ScienceStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Double Wood SupplementsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
RevgeneticsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Elysium HealthUndisclosed amounts noted
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
NOVOS LabsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Renue By ScienceMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
MAAC10Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
BulkSupplementsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
PartiqlarStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Nutriop LongevityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
WonderfeelMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Augment LifeStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
SolarayStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Innerbody LabsMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ToniiqStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
OmreStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
CADDARACFU not stored
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
AOR (Advanced Orthomolecular Research)Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Nootropics DepotStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
CodeageMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
LemmeMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Perpetua LifeMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
NutrieldStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
INSTYTUTUMStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Gundry MDUndisclosed amounts noted
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
INSTYTUTUMDaily use may exceed one serving
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Doctor's BestMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
TmrwMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
NutrieldStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Quicksilver ScientificStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside NMN in our catalogue.
See NMN in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View NMN on the Longevity Map →Your cells run on a molecule called NAD+. It powers energy production and DNA repair. NAD+ drops as we age. NMN is a compound your body converts into NAD+.
The trial dose in published human studies is 500 mg per day, with a range of 250 to 900 mg per day. Always consult a qualified clinician before starting any supplement.
No formal UL established by NIH/EFSA/FNB; long-term human safety data are still limited. Human trials show good tolerability up to 1,250 mg/day for 4 weeks, and EFSA's 2025/2026 novel food opinion approved NMN supplement use up to 300 mg/day.
We track 39 products containing NMN. The top-ranked product scores 8.3 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
NMN has evidence grade B, meaning it is supported by human RCTs. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.
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