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Category · 20 products

Metabolic

Glucose handling, insulin sensitivity and AMPK signalling. Where berberine and its neighbours live.

Category statistics and scoring
20
5.8
A
T2
4
$0.17
Compare the top 3 → Filter the full index →
Ranked

Every Metabolic product we score

Same formula as the rest of the site. Position here has never been bought.

Reading guide

How to read this shelf

Mostly berberine, plus calcium alpha-ketoglutarate and a few blends. Berberine labels state the salt (HCl is common) and often split the day into two or three doses. The catalog stores the total per label serving.

Check on every label

  • Whether the figure is per capsule or per day, and how many capsules the label's daily serving contains.
  • The salt form named (berberine HCl, dihydroberberine, Ca-AKG). The catalog does not convert between forms.
  • Many labels carry interaction warnings for berberine. Read the label warning and the safety section on this page.
Catalog figures for this shelf (20)
Products
20
Most common lead ingredients
Berberine (14), Ca-AKG (3), Calcium (1)
Forms
Capsule (17), Powder (2), Tablet (1)
Range of Berberine per serving
100 mg to 1,500 mg across 14 products
Price per serving
$0.07 to $3.67
Testing listed
15 of 20 list third-party testing · 6 publish a CoA
Multi-ingredient products
1 of 20 list three or more ingredients

Counts and ranges are catalog facts about the labels, not a ranking. The score, evidence and safety sections below are separate.

Top 3 for this shelf

The three best-evidenced options here, with the plain verdict and the catch first. The full ranking continues below.

01
DoNotAge
Pure Berberine
Metabolic
Active per serving
Berberine 1,500 mgPowder · 30 servings
Price per serving
$1.00$30.00 · 30 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 8.3/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$1.00
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org

Verdict: This DoNotAge Pure Berberine scores 9.1, making it one of the highest-scoring products on the site. It delivers 1500mg of Berberine, inside the studied range of 900–1500mg with grade A evidence (strong human trial data). Transparency is a clear strength (score: 9.5), with third-party testing and a public lab certificate.

02
Double Wood Supplements
Berberine Supplement
Metabolic
Active per serving
Berberine 500 mgCapsule · 60 servings
Price per serving
$0.33$19.95 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

56%
of trial dose
$1.00
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com

Verdict: This Double Wood Supplements Berberine Supplement scores 7.6, making it a strong scorer. It delivers 500mg of Berberine, 55% of the studied range low edge (900mg) with grade A evidence (strong human trial data). Transparency is a clear strength (score: 9.0), with third-party testing and a public lab certificate.

The catch: Berberine (500.0mg is 33% of the 1500mg trial dose) is significantly under-dosed.

03
Nootropics Depot
Berberine HCl 500 mg
Metabolic
Active per serving
Berberine 500 mgCapsule · 60 servings
Price per serving
$0.42$25.00 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

56%
of trial dose
$1.25
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with nootropicsdepot.com

Verdict: This Nootropics Depot Berberine HCl 500 mg scores 7.6, making it a strong scorer. It delivers 500mg of Berberine, 55% of the studied range low edge (900mg) with grade A evidence (strong human trial data). Transparency is a clear strength (score: 9.0), with third-party testing and a public lab certificate.

The catch: Berberine (500mg is 33% of the 1500mg trial dose) is significantly under-dosed.

Quick compare

Top 5 in Metabolic

Sorted by overall score. Same numbers you'll see on each product page.

#ProductScorePrimary activeDose vs RCTPrice/moValue rankDose+Evidence
#1Pure Berberine
DoNotAge
8.30/10Berberine 1500mg✅ 100%$30/moTop 24%10.0/10
#2Berberine Supplement
Double Wood Supplements
6.80/10Berberine 500mg⚠️ 55%$10/moTop 24%7.2/10
#3Berberine HCl 500 mg
Nootropics Depot
6.80/10Berberine 500mg⚠️ 55%$12/moMid-range7.2/10
#4Ca-AKG (Calcium Alpha-Ketoglutarate)
DoNotAge
6.80/10Calcium 400mg⚠️ 80%$4/moTop 1%6.3/10
#5Berbelean | Enhanced Berberine (Berberine Phytosome + Black Ginger, Saffron, CurCousin, Piperine)
Nootropics Depot
6.70/10Berberine 550mg⚠️ 61%$25/moMid-range7.3/10

Tied scores are shown to two decimals. Ties break in this order: dose vs study dose, then transparency, then value, then price per day at studied dose.

Show all 20 Metabolic products →
Metabolic
Active per serving
Calcium 400 mgElemental vs compound: check label
Price per serving
$0.13$49.00 · 366 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

80%
of trial dose
$0.17
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org
Metabolic
Active per serving
Berberine 550 mg+ Saffron 30 mg
Price per serving
$0.83$49.99 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

61%
of trial dose
$2.27
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with nootropicsdepot.com
06
Life Extension
Berberine
Metabolic
Active per serving
Berberine 510 mgCapsule · 60 servings
Price per serving
$0.41$24.75 · 60 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

57%
of trial dose
$1.21
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.lifeextension.com
Metabolic
Active per serving
Berberine 600 mg+ Alpha-Lipoic Acid 50 mg
Price per serving
$0.35$20.97 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.5/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

67%
of trial dose
$0.87
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.prohealth.com
08
BulkSupplements
Berberine HCl Powder
Metabolic
Active per serving
Berberine 500 mgPowder · 100 servings
Price per serving
$0.24$23.97 · 100 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 6.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

56%
of trial dose
$0.72
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.bulksupplements.com
09
Thorne HealthTech
Berberine-500
Metabolic
Active per serving
Berberine 500 mgCapsule · 30 servings
Price per serving
$1.47$44.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

56%
of trial dose
$4.40
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.thorne.com
10
Toniiq
Calcium AKG 1500
Metabolic
Active per serving
Ca-AKG 1,500 mg+ Calcium 200 mg
Price per serving
$0.62$24.97 · 40 servings
Testing
3rd-party listed · no public lab certificate

Elemental vs compound: check label

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.7/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$0.42
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.toniiq.com
11
Pure Encapsulations
Berberine UltraSorb
Metabolic
Active per serving
Berberine 550 mgCapsule · 30 servings
Price per serving
$1.72$51.50 · 30 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.4/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

61%
of trial dose
$4.68
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.pureencapsulationspro.com
12
Renue By Science
Lipo Berberine
Metabolic
Active per serving
Berberine 250 mgCapsule · 90 servings
Price per serving
$0.56$49.95 · 90 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

28%
of trial dose
$3.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with supp.co
13
Double Wood Supplements
Dihydroberberine Supplement (GlucoVantage)
Metabolic
Active per serving
Berberine 100 mgCapsule · 60 servings
Price per serving
$0.38$22.95 · 60 servings
Testing
3rd-party listed · public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.2/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

11%
of trial dose
$5.74
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with doublewoodsupplements.com
14
Renue By Science
Berberine (Liposomal)
Metabolic
Active per serving
Berberine 250 mgCapsule · 90 servings
Price per serving
$0.56$49.95 · 90 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

28%
of trial dose
$3.33
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with renuebyscience.com
Metabolic
Active per serving
NMN 100 mgCapsule · 30 servings
Price per serving
$2.30$69.00 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.1/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

40%
of trial dose
$11.50
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with nutrieldus.com
Metabolic
Active per serving
Ca-AKG 1,000 mgTablet · 30 servings
Price per serving
$3.67$109.95 · 30 servings
Testing
3rd-party listed · no public lab certificate

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 5.0/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$3.67
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with rejuvant.com
Metabolic
Active per serving
Berberine 500 mgCapsule · 30 servings
Price per serving
$1.17$34.99 · 30 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.9/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

56%
of trial dose
$3.50
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with frishantic.com
18
DoNotAge
Probiotic
Metabolic
Active per serving
Prebiotic Fiber 100 mgCapsule · 366 servings
Price per serving
$0.07$24.99 · 366 servings
Testing
None listed

CFU not stored

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.8/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

5%
of trial dose
$3.41
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with donotage.org
Metabolic
Ingredients listed
3 ingredients listedlargest listed: Berberine 500 mg
Price per serving
$1.83$54.87 · 30 servings
Testing
3rd-party listed · no public lab certificate

Multi-ingredient bundle

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

56%
of trial dose
$5.49
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with viviyouth.com
20
Supersmart
Calcium AKG
Metabolic
Active per serving
Ca-AKG 1,000 mgCapsule · 30 servings
Price per serving
$3.30$99.00 · 30 servings
Testing
None listed

Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.

Score & research context 4.6/10

Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.

100%
of trial dose
$3.30
per research-dose day, not label serving
0Trial dose2×
Catalog price · Confirm current price with www.supersmart.com
Connected

What defines this shelf

Actives used here
Berberine (14)Ca-AKG (3)Calcium (2)Alpha-Lipoic Acid (2)Saffron (1)NMN (1)Prebiotic Fiber (1)Piperine (1)
Brands competing
DoNotAge (3)Double Wood Supplements (2)Nootropics Depot (2)Renue By Science (2)Life Extension (1)ProHealth Longevity (1)BulkSupplements (1)Thorne HealthTech (1)Toniiq (1)Pure Encapsulations (1)Nutrield (1)Rejuvant (1)Frishantic (1)ViViYouth (1)Supersmart (1)
Consumer signals
19 products with consumer ratings 8 high-confidence signals 6,654,759 total consumer reviews
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