The autophagy-inducing polyamine; the largest human trial found no cognitive benefit.
One of the more promising 'gerotherapeutics' with human data. Wheat-germ extract products vary widely in actual spermidine content, insist on assay-verified milligrams.
Spermidine (Spermidine) is a autophagy with evidence grade C, meaning it is backed by mixed or small human trials. We track 26 products containing Spermidine. Typical doses range from 1 to 15 mg per serving. The top-ranked product scores 7.1 out of 10 on our composite scale (dose, evidence, price, testing, transparency). Prices range up to $74.00 per month.
| Product | Brand | Dose | Price/mo | 3rd-party tested | Score |
|---|---|---|---|---|---|
| Pure Spermidine - 1 mg, 180 capsules | ProHealth Longevity | 1 mg | $29.95 | Yes | 7.1 |
| Daily Longevity Blend | AgeMate | 5 mg | $69.00 | Yes | 7.0 |
| NAD+ Support | Innerbody Labs | 15 mg | $74.00 | Yes | 6.9 |
| Pure Spermidine | DoNotAge | 10 mg | $60.00 | Yes | 6.9 |
| Spermidine 8 mg | Double Wood Supplements | 8 mg | $35.00 | Yes | 6.9 |
Scores are editorial judgments, not a scientific standard. See how we score.
A molecule your cells make and that's also in aged cheese, wheat germ, and soy. It triggers autophagy, the cellular recycling process that clears out damaged parts.
Observational studies link high spermidine intake to lower mortality. The largest human trial, SmartAge (2022), tested 0.9 mg/day for 12 months in 100 older adults and found no cognitive benefit versus placebo. Larger trials are in progress.
One of the more promising 'gerotherapeutics' with human data. Wheat-germ extract products vary widely in actual spermidine content, insist on assay-verified milligrams.
Symmetric polyamine (N-(3-aminopropyl)-1,4-butanediamine). Induces autophagy via EP300 inhibition; hypusinates eIF5A.
Kiechl et al. 2018 (Am J Clin Nutr) showed dietary spermidine inversely associated with all-cause mortality. SmartAge (Schwarz et al. 2022, JAMA Network Open) found no change in mnemonic discrimination at 0.9 mg/day for 12 months in adults with subjective cognitive decline (difference -0.03, 95% CI -0.11 to 0.05, P=.47).
Rapid absorption; polyamine pool has slow turnover.
Product labels often say 'wheat germ extract 800 mg', that could be 0.8 mg or 8 mg of actual spermidine. Insist on labeled spermidine content.
When a product exceeds the UL or contains an ingredient with clinically significant interactions, a "Review advised" flag appears on its product page and links here.
Source: https://www.sciencedirect.com/science/article/abs/pii/S027153172400126X
The trial dose above is our editorial pick from the published human trials for this ingredient. We choose the dose that the best-available studies used on the endpoint most relevant to longevity. The range shows the lowest and highest doses tested in published trials. The landmark studies below are the papers we read to set it. You can click through and check our work.
When new trials publish, our automated sweeps flag them. If a new study materially changes the dose, we update it through editorial review and record the old dose, new dose, and the triggering study in every affected product's recommendation history. The dose is never changed automatically.
Regulatory events, evidence grade changes, and key research milestones for Spermidine, most recent first. Studies link to the paper; regulatory entries name and link the responsible authority.
Verified 2026-08-06. We update this section as new peer-reviewed trials land.
The strongest human evidence for spermidine is a small positive signal, not a confirmed benefit. Anna-Katharina Schwarz's 2018 pilot trial found spermidine supplementation moderately improved mnemonic discrimination in 30 older adults over 3 months, Cohen's d of 0.79 (https://pubmed.ncbi.nlm.nih.gov/30388439/). This pilot result motivated a larger follow-up. That larger trial, the 100-person SmartAge study led by Anna Flöel and Christian Schwarz, ran for 12 months and found no significant benefit on the same primary memory measure (https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2792725). The field's own confirmatory trial did not replicate the pilot signal.
Marketers present spermidine as a proven cognitive and longevity supplement based on autophagy research in worms, flies, and mice. The best-designed, largest human trial to date, SmartAge, found 12 months of spermidine supplementation did not modify memory or other biomarkers in people at risk for Alzheimer's disease (https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2792725). A 2023 pharmacokinetic study by Stefan Senekowitsch and colleagues raises a more basic problem: high-dose spermidine supplementation did not measurably increase spermidine levels in blood plasma or saliva of healthy adults, suggesting the body tightly regulates spermidine and oral supplements may not change tissue exposure the way marketing implies (https://pmc.ncbi.nlm.nih.gov/articles/PMC10143675/). No human trial has shown spermidine extends lifespan or reverses aging markers.
1-6 mg once daily as spermidine-rich plant extract, though pharmacokinetic data cast doubt on absorption
Spermidine appears safe at studied doses. Patrick Keohane and colleagues' 2024 trial of a novel high-purity spermidine supplement at 40 mg/day in 37 healthy older men found no significant changes in clinical, lipid, chemistry, or hematological parameters, and no product-related adverse events over 28 days (https://linkinghub.elsevier.com/retrieve/pii/S027153172400126X). Long-term safety beyond a year has not been established in a randomized trial.
12-month RCT in 100 adults with subjective cognitive decline: 0.9 mg/day spermidine did not improve memory or biomarkers versus placebo.
Read study →Comprehensive review identifying eIF5A-TFEB axis as central autophagy mechanism. SmartAge Phase IIb showed no memory improvement at 12 months. 3.3 mg/day rice germ extract improved cardiometabolic biomarkers. 40 mg/day high-purity spermidine safe for 28 days in older men.
Read study →All products in our catalog that contain Spermidine, ranked by our overall score. Ranking is editorial, never paid.
ProHealth LongevityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
AgeMateMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Innerbody LabsMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
DoNotAgeStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Double Wood SupplementsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
GenuinePurityStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
AOR (Advanced Orthomolecular Research)Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Renue By ScienceStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Multi-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Green as NatureStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Neurogan HealthStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
SolarayDaily use may exceed one serving
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Longevity LabsElemental vs compound: check label
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Longevity LabsElemental vs compound: check label
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Oxford HealthspanStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
LemmeMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
SupersmartStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Oxford HealthspanStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Oxford HealthspanStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Perpetua LifeMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
RevgeneticsStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
ToniiqStatus as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
TmrwMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Renue By ScienceMulti-ingredient bundle
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Molecules in the same class, plus the actives most often formulated alongside Spermidine in our catalogue.
See Spermidine in context: the mechanism it acts through, the biomarker it moves, the products that dose it, and the trials that tested it.
View Spermidine on the Longevity Map →A molecule your cells make and that's also in aged cheese, wheat germ, and soy. It triggers autophagy, the cellular recycling process that clears out damaged parts.
The trial dose in published human studies is 1.2 mg per day, with a range of 0.9 to 6 mg per day. Always consult a qualified clinician before starting any supplement.
No formal UL (not an essential nutrient); short-term trials show no adverse effects at doses up to 40 mg/day for 28 days, well above typical dietary/supplemental intake (~6 mg/day).
We track 26 products containing Spermidine. The top-ranked product scores 7.1 out of 10 on our composite scale, which evaluates dose, evidence, price, third-party testing, and transparency. See the comparison table above. Scores are editorial judgments, not a scientific standard.
Spermidine has evidence grade C, meaning it is backed by mixed or small human trials. Grade A means replicated human RCTs with hard endpoints. Grade B means human RCTs with biomarker outcomes. Grade C means mixed or small human trials. See our evidence grading methodology.
Evidence grades are reviewed when new human RCTs are published. Product counts update automatically as new products are added. Dose ranges reflect published trial data, not brand recommendations. Read how we verify.
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