Understand the evidence. Compare the products. Make your own decision.
The trial used 2 grams. The capsule has 300 milligrams. That gap is the most common problem across 316 products, and we score it directly: every dose is compared against the dose in the study the label points to. Plenty of bestsellers sit at 10 to 30 percent of it.
0 rankings paid for · 316 products scored the same way
The research, the dose and the gaps in what we know. All in one place.
Start with a plain-language explanation. Then check the human studies, safety notes and unanswered questions.
Explore ingredients → 02 / Compare the detailsPut products side by side. See the dose, the price and what each brand discloses.
Try a product comparison →Simple explanations. Important differences. No prior knowledge needed.
Answer three quick questions and we match you to the best-evidenced pick for your goal, with the honest catch first. No brand pays for a spot here.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
EPA/DHA split not stored
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Status as recorded in the catalog from brand materials; not independently verified by NO1GEVITY.
Editorial score, not proof that this product works. Research-dose calculations are not dosing advice.
Basics shows the verdict. Advanced adds the study trail, dose tables and the full research log behind every score. Switch any time in the bar above.
Pick up two jars of NMN. Both say 500 mg. One is 99% pure. The other has none. That's not a hypothetical: in a 2021 analysis of 22 popular NMN products sold on Amazon, 14 contained less than 1% of the NMN stated on the label, including three where none was detected. Read the full testing breakdown →
And the label is only the first problem. To know if the dose in that bottle matches what a trial actually used, you need to find the trial. To know if the ingredient works at that dose, you need to read the trial. To know if the brand has a recall history, you check FDA. To know what a fair price is, you divide the price by the number of day at studied doses. Nobody does all of that before buying a supplement. We built this site so you don't have to.
On top of that: blends without listed amounts hide the dose of every ingredient inside them, so the one number that decides whether the product can work is not printed anywhere. Star ratings on Amazon measure whether people liked opening the package, not whether the capsule did anything. And the "honest reviews" on YouTube are usually paid commissions in an FTC-required disclosure printed too small to read.
We read the human trials for every ingredient we cover and gave each one an evidence grade from A to F. We took every product and checked the actual dose in the bottle against the dose the trial actually used. We divided every price by the number of days at that dose, so you can compare a $30 jar to a $200 jar honestly. We logged which brands publish a certificate of analysis and which don't. Then we ran all of it through the same scoring method, the same way, every time. Brands can't pay to move up. No editor overrides the number.
See the exact formula → Or jump straight to the full ranking →
Not the top of the leaderboard: the top of a stated constraint. Each pick names the rule we applied, the numbers behind it, and the reason you might still want something else.
A 500mg serving matches the trial dose, and the 200-serving tub keeps the daily cost near 10 cents. The formula is plain NMN powder with third-party testing and a public certificate of analysis, not a more complicated blend.
At 27 cents per day at studied dose, this fish oil undercuts most competitors while still carrying third-party testing and a public lab certificate. The 750mg combined EPA/DHA per softgel is a meaningful dose, though you need 3 softgels to reach the 2000mg used in major cardiovascular trials.
600mg of alpha-lipoic acid at 13 cents per day is the cheapest path to a full grade-A trial dose on the entire site. The ingredient has strong human evidence for diabetic neuropathy and solid antioxidant data.
Calcium alpha-ketoglutarate at the 800mg trial dose for 17 cents per day, with third-party testing. The Ca-AKG molecule has human data from the Rejuvant trial, making it one of the better-evidenced metabolic longevity candidates.
A genuinely high-potency multivitamin with 25+ actives including active 5-MTHF folate, chelated minerals, and vitamin D3, at 43 cents per day. Three grade-A ingredients (vitamin C, magnesium, zinc) land at or near their trial doses.
Standardized to 20% bacosides at 450mg per capsule, this bacopa hits 150% of the 300mg trial dose at just 13 cents per day. Tested by independent lab with a public lab certificate.
At $39.99 per month, this single-ingredient Magtein product posts the Mineral category's highest value score (9.9). The listing identifies third-party testing and a public lab certificate.
IFOS third-party certification plus a published certificate of analysis puts this fish oil at the top of our transparency sub-score, ahead of every other product that also carries both badges. The 1200mg combined EPA+DHA per serving is stated directly rather than buried in a blend without listed amounts.
Composite 7.9, the highest score among foundational multis in the catalog. Tested by independent lab with methylated B-complex (5-MTHF folate, methylcobalamin B12), vitamin D3 50 mcg, vitamin K2 400 mcg, chelated zinc 15 mg, and selenium 200 mcg in two capsules per day at 32 USD per month.
Human data on fisetin is still early-stage: most of what we have comes from animal studies, not people yet. But among the fisetin products we scored, this one hits the full trial dose and publishes a certificate of analysis, where others fall short on dose, price, or both.
Covers 5 of 7 canonical longevity mechanisms at 25%+ of studied dose in a single third-party-tested formula: autophagy/senolytic (fisetin 150 mg, pterostilbene 50 mg), metabolic/AMPK (calcium alpha-ketoglutarate 500 mg), methylation/amino (glycine 1000 mg), sirtuin/polyphenol (pterostilbene), and structural (glucosamine sulfate 500 mg, hyaluronic acid 150 mg). 12 ingredients at 89 USD per month, powder sachets for adjustable dosing.
If you are buying your first longevity supplement, buy the molecule with hundreds of human trials behind it rather than the one with the best marketing. Creatine monohydrate is the closest thing this field has to a settled answer, and it is a single ingredient with no stack to figure out.
Every pick starts from the same overall score the whole site runs on: 0.50·Dose vs. studies + 0.20·Transparency + 0.10·Value + 0.10·Formulation + 0.05·Safety + 0.05·Community. We then apply one extra constraint per category, such as lowest cost per day at studied dose or highest transparency with a public lab certificate, and take the winner. The constraint is printed on the card so you can check our work. See the full composite-score method →
Nobody paid to appear here and nobody was told they were being considered. We sell labelled ad space; we do not sell position, order, or wording. Advertisers are contacted for ad bookings only, never for scoring or inclusion in picks. If that changes, it will be disclosed on this page before it appears anywhere else.
A recommendation without a caveat is marketing. Where a pick is expensive, undocumented, or resting on early-phase human data, that appears on the card in the same type size as the praise.
All rationales are original text written by the editorial team from primary sources and our own scoring output. We never reproduce vendor copy. Full methodology →
Pick a health biomarker — ApoB, DunedinPACE, vitamin D — and follow the chain: the mechanism that moves it, the molecule that targets it, the products that dose it, and the trials that tested it. One interactive page, every link clickable.
One homepage slot per week. Labelled. Never near the rankings.
Read the advertising policy →We're transparent about what we've read. Every rank on this site pulls from the same encyclopedia of primary sources, updated weekly.
Every number links to the underlying page. Every study we cite is verified to resolve to a real published source. Automated research sweeps run daily to pull in new studies and protocol changes, so the numbers here reflect what is published, not what was published last quarter.
Independent ranking of 10+ NMN products by dose, price, testing and evidence grade.
Side-by-side comparison of the two most popular NAD+ precursors: evidence, dose, price, regulatory status.
Independent ranking of spermidine products by dose, price, testing and evidence grade.
Each category page ranks every product in it with the same scoring method, and links out to the ingredients that define it.
Pick two. See what is actually in them: dose per serving, price per day at studied dose, third-party testing and evidence grade, side by side. Then take it further on the full comparison page.
Every brand page lists their full range, our average score for it, and the actives they lean on.
Each ingredient explained twice: once in plain English, once for readers who want the pharmacology. Every page opens with the evidence grade, A to F, and the doses the trials actually used.
Thorne HealthTech
Nordic Naturals
Transparent Labs
ProHealth Longevity
Timeline Nutrition